Entity Details

Primary name ADA2C_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18825
EntryNameADA2C_HUMAN
FullNameAlpha-2C adrenergic receptor
TaxID9606
Evidenceevidence at protein level
Length462
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesADRA2C

GO terms

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GOName
GO:0004930 G protein-coupled receptor activity
GO:0004938 alpha2-adrenergic receptor activity
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007565 female pregnancy
GO:0010700 negative regulation of norepinephrine secretion
GO:0030168 platelet activation
GO:0031694 alpha-2A adrenergic receptor binding
GO:0032148 activation of protein kinase B activity
GO:0032811 negative regulation of epinephrine secretion
GO:0035624 receptor transactivation
GO:0042803 protein homodimerization activity
GO:0043025 neuronal cell body
GO:0043410 positive regulation of MAPK cascade
GO:0043679 axon terminus
GO:0045666 positive regulation of neuron differentiation
GO:0045907 positive regulation of vasoconstriction
GO:0046982 protein heterodimerization activity
GO:0050796 regulation of insulin secretion
GO:0051379 epinephrine binding
GO:0051930 regulation of sensory perception of pain
GO:0070473 negative regulation of uterine smooth muscle contraction
GO:0071875 adrenergic receptor signaling pathway
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0098978 glutamatergic synapse
GO:0099061 integral component of postsynaptic density membrane

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000735 Alpha 2C adrenoceptorFamilyFamily
IPR002233 Adrenoceptor familyFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00182 AmphetamineDrugbanksmall molecule
DB00193 TramadolDrugbanksmall molecule
DB00217 BethanidineDrugbanksmall molecule
DB00246 ZiprasidoneDrugbanksmall molecule
DB00248 CabergolineDrugbanksmall molecule
DB00268 RopiniroleDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00368 NorepinephrineDrugbanksmall molecule
DB00397 PhenylpropanolamineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00433 ProchlorperazineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00484 BrimonidineDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00575 ClonidineDrugbanksmall molecule
DB00589 LisurideDrugbanksmall molecule
DB00696 ErgotamineDrugbanksmall molecule
DB00697 TizanidineDrugbanksmall molecule
DB00714 ApomorphineDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00734 RisperidoneDrugbanksmall molecule
DB00797 TolazolineDrugbanksmall molecule
DB00800 FenoldopamDrugbanksmall molecule
DB00925 PhenoxybenzamineDrugbanksmall molecule
DB00934 MaprotilineDrugbanksmall molecule
DB00935 OxymetazolineDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01136 CarvedilolDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01175 EscitalopramDrugbanksmall molecule
DB01186 PergolideDrugbanksmall molecule
DB01200 BromocriptineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01267 PaliperidoneDrugbanksmall molecule
DB01363 Ephedra sinica rootDrugbankbiotech
DB01365 MephentermineDrugbanksmall molecule
DB01392 YohimbineDrugbanksmall molecule
DB01403 MethotrimeprazineDrugbanksmall molecule
DB01576 DextroamphetamineDrugbanksmall molecule
DB01577 MetamfetamineDrugbanksmall molecule
DB04846 CeliprololDrugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB04946 IloperidoneDrugbanksmall molecule
DB05461 OPC-28326Drugbanksmall molecule
DB05492 Epicept NP-1Drugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06153 PizotifenDrugbanksmall molecule
DB06216 AsenapineDrugbanksmall molecule
DB06229 OcaperidoneDrugbanksmall molecule
DB06262 DroxidopaDrugbanksmall molecule
DB06678 EsmirtazapineDrugbanksmall molecule
DB06694 XylometazolineDrugbanksmall molecule
DB06707 LevonordefrinDrugbanksmall molecule
DB08815 LurasidoneDrugbanksmall molecule
DB08838 AgmatineDrugbanksmall molecule
DB09128 BrexpiprazoleDrugbanksmall molecule
DB09167 DosulepinDrugbanksmall molecule
DB09194 EtoperidoneDrugbanksmall molecule
DB09195 LorpiprazoleDrugbanksmall molecule
DB09202 CirazolineDrugbanksmall molecule
DB09205 MoxisylyteDrugbanksmall molecule
DB09229 AranidipineDrugbanksmall molecule
DB09304 SetiptilineDrugbanksmall molecule
DB11124 RacepinephrineDrugbanksmall molecule
DB11273 DihydroergocornineDrugbanksmall molecule
DB11278 DL-MethylephedrineDrugbanksmall molecule
DB11477 XylazineDrugbanksmall molecule
DB11577 Indigotindisulfonic acidDrugbanksmall molecule
DB13025 TiaprideDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule