Entity Details

Primary name DCHS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19113
EntryNameDCHS_HUMAN
FullNameHistidine decarboxylase
TaxID9606
Evidenceevidence at protein level
Length662
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesHDC

GO terms

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GOName
GO:0001694 histamine biosynthetic process
GO:0004398 histidine decarboxylase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006547 histidine metabolic process
GO:0006548 histidine catabolic process
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0042423 catecholamine biosynthetic process

Subcellular Location

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Domains

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DomainNameCategoryType
IPR002129 Pyridoxal phosphate-dependent decarboxylaseFamilyFamily
IPR010977 Aromatic-L-amino-acid decarboxylaseFamilyFamily
IPR015421 Pyridoxal phosphate-dependent transferase, major domainFamilyHomologous superfamily
IPR015422 Pyridoxal phosphate-dependent transferase, small domainFamilyHomologous superfamily
IPR015424 Pyridoxal phosphate-dependent transferaseFamilyHomologous superfamily
IPR021115 Pyridoxal-phosphate binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB00114 Pyridoxal phosphateDrugbanksmall molecule
DB00117 HistidineDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
DCHS_HUMANDTX2_HUMANBioGRID, IntAct25416956 details
DCHS_HUMANGRAA_HUMANBioGRID19059912 details