Entity Details

Primary name CD22_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20273
EntryNameCD22_HUMAN
FullNameB-cell receptor CD22
TaxID9606
Evidenceevidence at protein level
Length847
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesCD22

GO terms

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GOName
GO:0001791 IgM binding
GO:0002638 negative regulation of immunoglobulin production
GO:0005102 signaling receptor binding
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007155 cell adhesion
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0019903 protein phosphatase binding
GO:0030100 regulation of endocytosis
GO:0030246 carbohydrate binding
GO:0030888 regulation of B cell proliferation
GO:0032809 neuronal cell body membrane
GO:0033691 sialic acid binding
GO:0042113 B cell activation
GO:0042609 CD4 receptor binding
GO:0050776 regulation of immune response
GO:0050849 negative regulation of calcium-mediated signaling
GO:0050859 negative regulation of B cell receptor signaling pathway
GO:0055037 recycling endosome
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013162 CD80-like, immunoglobulin C2-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB04958 EpratuzumabDrugbankbiotech
DB05889 Inotuzumab ozogamicinDrugbankbiotech
DB12688 Moxetumomab PasudotoxDrugbankbiotech