Entity Details

Primary name THAS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP24557
EntryNameTHAS_HUMAN
FullNameThromboxane-A synthase
TaxID9606
Evidenceevidence at protein level
Length533
SequenceStatuscomplete
DateCreated1992-03-01
DateModified2021-06-02

Ontological Relatives

GenesTBXAS1

GO terms

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GOName
GO:0001516 prostaglandin biosynthetic process
GO:0004497 monooxygenase activity
GO:0004796 thromboxane-A synthase activity
GO:0005506 iron ion binding
GO:0005789 endoplasmic reticulum membrane
GO:0006690 icosanoid metabolic process
GO:0016021 integral component of membrane
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0019371 cyclooxygenase pathway
GO:0020037 heme binding
GO:0036134 12-hydroxyheptadecatrienoic acid synthase activity
GO:0106256 hydroperoxy icosatetraenoate dehydratase activity

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002401 Cytochrome P450, E-class, group IFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00795 SulfasalazineDrugbanksmall molecule
DB01207 RidogrelDrugbanksmall molecule
DB03052 DazoxibenDrugbanksmall molecule
DB05505 NM-702Drugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
THAS_HUMANUBC_HUMANBioGRID23314748 details