Entity Details

Primary name IKBA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25963
EntryNameIKBA_HUMAN
FullNameNF-kappa-B inhibitor alpha
TaxID9606
Evidenceevidence at protein level
Length317
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesNFKBIA

GO terms

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GOName
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006606 protein import into nucleus
GO:0006915 apoptotic process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007253 cytoplasmic sequestering of NF-kappaB
GO:0008134 transcription factor binding
GO:0008139 nuclear localization sequence binding
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010875 positive regulation of cholesterol efflux
GO:0010888 negative regulation of lipid storage
GO:0016032 viral process
GO:0016579 protein deubiquitination
GO:0019899 enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032495 response to muramyl dipeptide
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033256 I-kappaB/NF-kappaB complex
GO:0034142 toll-like receptor 4 signaling pathway
GO:0035994 response to muscle stretch
GO:0042127 regulation of cell population proliferation
GO:0042802 identical protein binding
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0043066 negative regulation of apoptotic process
GO:0043330 response to exogenous dsRNA
GO:0043392 negative regulation of DNA binding
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050729 positive regulation of inflammatory response
GO:0051059 NF-kappaB binding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070417 cellular response to cold
GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070498 interleukin-1-mediated signaling pathway
GO:1901222 regulation of NIK/NF-kappaB signaling

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002110 Ankyrin repeatRepeatRepeat
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB05983 Bardoxolone methylDrugbanksmall molecule
DB06543 AstaxanthinDrugbanksmall molecule

Interactions

156 interactions

InteractorPartnerSourcesPublicationsLink
IKBA_HUMANFBW1A_HUMANBioGRID, HPRD, IntAct, MINT10066435 10075690 10497169 10644755 10713156 11027288 12482991 19053519 19933270 20353940 20558726 20638939 20797629 20851351 22022389 22388891 22590978 24464578 24912152 25190485 25900982 27001857 29499133 32051583 9859996 9990852 9990853 details
IKBA_HUMANADT2_HUMANHPRD, IntAct11287411 14743216 details
IKBA_HUMANNFKB1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11020244 11313474 14743216 16210649 17003112 20237821 20558726 20980497 21483817 21988832 22536447 25609649 26186194 26496610 27609421 28514442 29439025 7739549 7891711 8631829 8887676 9566883 9572494 9738011 9865693 details
IKBA_HUMANTERA_HUMANBioGRID, HPRD, IntAct10930447 14743216 23383273 23393163 24248593 26463447 9452483 details
IKBA_HUMANFBW1B_HUMANBioGRID, HPRD, IntAct10066435 10230406 10644755 12165731 12482991 14743216 17698585 24912152 26186194 27565346 28514442 details
IKBA_HUMANPTN13_HUMANBioGRID, HPRD, IntAct11106428 14743216 9882613 details
IKBA_HUMANTF65_HUMANBioGRID, DIP, HPRD, I2D, IntAct, MINT, UniProt10066434 10085161 10498867 11020244 11231305 11287411 11313474 11533489 12419806 14685242 14690596 14743216 15657065 15799966 16105840 16280327 16683270 16951195 17003112 17301240 17362989 17612295 17709515 18045535 19219072 20065107 20551178 20797629 20876301 20980497 21217772 21483817 21988832 22022389 22081069 23185316 23563313 23850221 24248593 24457201 24634218 25520503 25609694 25759022 26186194 26463447 26476452 26496610 27609421 27923823 28514442 29084252 29439025 29734393 30213788 30542119 30628021 7628694 7739549 7878004 8139561 8246997 8657102 8887627 8887633 8978697 9057089 9566883 9572494 9738011 9751059 9865693 9990853 details
IKBA_HUMANIKBB_HUMANBioGRID, HPRD, IntAct14743216 22081069 26186194 28514442 details
IKBA_HUMANELP1_HUMANBioGRID, HPRD, IntAct14743216 9751059 details
IKBA_HUMANIKKA_HUMANBioGRID, HPRD, InnateDB, IntAct, UniProt10094049 10733566 11042193 11080499 11095741 11113112 11809792 11940602 12054687 12138192 12190313 12411322 12486103 12624112 12730857 14743216 15310755 15389589 15590691 15670770 16219905 16286467 16319058 16354686 17053167 17363905 17379600 17384642 18003900 18074035 18501560 18519641 18922877 18949366 19959994 20133937 20434986 20449947 20932476 21765415 23602409 24270572 24618592 26186194 28514442 29958295 9244310 9252186 9346485 9520446 9689078 9721103 9751059 9914500 details
IKBA_HUMANIKKB_HUMANBioGRID, DIP, HPRD, InnateDB, IntAct, MINT, UniProt11080499 12054687 12411322 12486103 12624112 12709429 12943667 14743216 15125833 15125834 15217903 15218148 15456896 15919917 16126728 16286467 16291755 16319058 16365431 16611882 17079871 17363905 18202307 18375836 18519641 18593939 18981174 19196987 19345327 19959994 20434986 20449947 20797629 21399639 21423167 21765415 22022389 22037600 22904686 22990857 23816567 24469399 24611898 24618592 24912152 25595906 25759022 26221961 26740240 26802121 27387502 27497262 28214532 29650758 29958295 30254148 32555320 9346485 9520446 9689078 9721103 9751059 9891086 9914500 details
IKBA_HUMANNEMO_HUMANBioGRID, HPRD, I2D, IntAct, MINT11064457 11830587 14743216 15218148 15670770 15749833 16126728 16319058 16547522 17363973 18429822 18519641 18957422 19959994 21217772 21811235 21862596 21896478 22081069 23732909 23746843 26496610 26865630 32246052 details
IKBA_HUMANSKP1_HUMANBioGRID, HPRD, IntAct10066435 10230406 10514433 14743216 22590978 24912152 29499133 9990852 details
IKBA_HUMANMED19_HUMANBioGRID, HPRD, IntAct16169070 details
IKBA_HUMANP121A_HUMANBioGRID, HPRD, IntAct16189514 32296183 details
IKBA_HUMANRWDD3_HUMANBioGRID, IntAct17956732 details
IKBA_HUMANATF4_HUMANBioGRID, IntAct18255255 details
IKBA_HUMANZN212_HUMANBioGRID, IntAct18255255 details
IKBA_HUMANIKZF4_HUMANBioGRID, IntAct18255255 details
IKBA_HUMANPTN1_HUMANHPRD, MINT8940099 details
IKBA_HUMANARRB1_HUMANBioGRID, HPRD, IntAct15125834 15173580 19879840 details
IKBA_HUMANP85A_HUMANBioGRID, HPRD, MINT9892650 details
IKBA_HUMANCD7_HUMANBioGRID, IntAct21988832 details
IKBA_HUMANRPB3_HUMANBioGRID, IntAct21988832 details
IKBA_HUMANST7_HUMANBioGRID, IntAct21988832 details
IKBA_HUMANHIF1N_HUMANBioGRID, DIP, IntAct17003112 26186194 26972000 28514442 details
IKBA_HUMANCASL_HUMANBioGRID, IntAct25416956 32296183 details
IKBA_HUMANPSMD3_HUMANBioGRID, IntAct32296183 details
IKBA_HUMANENKD1_HUMANBioGRID, IntAct32296183 details
IKBA_HUMANTCL1A_HUMANBioGRID, IntAct32296183 details
IKBA_HUMANGRK5_HUMANDIP19008357 details
IKBA_HUMANARBK1_HUMANDIP19008357 details
IKBA_HUMANSUMO4_HUMANBioGRID, HPRD15247916 19222990 details
IKBA_HUMANPIR_HUMANBioGRID10362352 details
IKBA_HUMANBARD1_HUMANBioGRID10362352 details
IKBA_HUMANP53_HUMANBioGRID, HPRD11799106 15969767 details
IKBA_HUMANROA1_HUMANBioGRID, HPRD11313474 details
IKBA_HUMANDYL1_HUMANBioGRID, HPRD9372968 details
IKBA_HUMANKS6A1_HUMANBioGRID, HPRD10723127 8601309 9214631 9261139 9721103 9914500 details
IKBA_HUMANG3BP2_HUMANBioGRID, HPRD10969074 details
IKBA_HUMANCAN1_HUMANBioGRID, HPRD10521480 details
IKBA_HUMANM3K14_HUMANBioGRID9751059 details
IKBA_HUMANLYL1_HUMANBioGRID10023675 details
IKBA_HUMANHXB7_HUMANBioGRID, HPRD10026139 details
IKBA_HUMANUB2D1_HUMANBioGRID9362451 9409737 details
IKBA_HUMANAURKA_HUMANBioGRID17060341 details
IKBA_HUMANPSA2_HUMANBioGRID16098527 details
IKBA_HUMANABL1_HUMANBioGRID12167702 details
IKBA_HUMANADT1_HUMANBioGRID, HPRD11287411 details
IKBA_HUMANUB2R1_HUMANBioGRID, HPRD10329681 20347421 details
IKBA_HUMANCSK2B_HUMANBioGRID10398585 20797629 details
IKBA_HUMANUB2D3_HUMANBioGRID, HPRD10329681 20347421 details
IKBA_HUMANUB2D2_HUMANBioGRID, HPRD10329681 details
IKBA_HUMANUB2L3_HUMANBioGRID10329681 details
IKBA_HUMANKS6A3_HUMANBioGRID22685297 details
IKBA_HUMANITPK1_HUMANBioGRID12324474 details
IKBA_HUMANM3K1_HUMANBioGRID14500727 details
IKBA_HUMANDNJA3_HUMANBioGRID15601829 details
IKBA_HUMANIKKE_HUMANBioGRID, HPRD10421793 20449947 details
IKBA_HUMANTBK1_HUMANBioGRID, HPRD10783893 20449947 8601309 9721103 details
IKBA_HUMANARRB2_HUMANBioGRID, HPRD15125834 15173580 details
IKBA_HUMANKPCA_HUMANBioGRID10398585 details
IKBA_HUMANTNFA_HUMANBioGRID7739525 details
IKBA_HUMANUBC9_HUMANBioGRID9409737 9734360 details
IKBA_HUMANM3K7_HUMANBioGRID15327770 details
IKBA_HUMANCASR_HUMANBioGRID19456861 details
IKBA_HUMANRN115_HUMANBioGRID28122985 details
IKBA_HUMANUB2E3_HUMANHPRD10582246 9409737 9734360 details
IKBA_HUMANREL_HUMANBioGRID, HPRD, IntAct10706725 14743216 25759022 26186194 26496610 27609421 28514442 8887627 details
IKBA_HUMANHS71L_HUMANIntAct14743216 details
IKBA_HUMANBIP_HUMANIntAct14743216 details
IKBA_HUMANHSP7C_HUMANIntAct14743216 details
IKBA_HUMANRS27L_HUMANIntAct14743216 details
IKBA_HUMANGRP75_HUMANIntAct14743216 details
IKBA_HUMANRL23_HUMANIntAct14743216 details
IKBA_HUMANRPOM_HUMANBioGRID, IntAct14743216 26186194 28514442 details
IKBA_HUMANMCM3_HUMANIntAct14743216 details
IKBA_HUMANIKBA_HUMANHPRD, IntAct14743216 16951195 details
IKBA_HUMANACTG_HUMANIntAct14743216 details
IKBA_HUMANCLH1_HUMANIntAct14743216 details
IKBA_HUMANTIM50_HUMANIntAct14743216 details
IKBA_HUMANCALM2_HUMANIntAct14743216 details
IKBA_HUMANSPRR3_HUMANIntAct14743216 details
IKBA_HUMANTBB5_HUMANIntAct14743216 details
IKBA_HUMANTBB4A_HUMANIntAct14743216 details
IKBA_HUMANNFKB2_HUMANBioGRID, HPRD, IntAct14743216 26186194 26496610 28514442 details
IKBA_HUMANELP3_HUMANIntAct14743216 details
IKBA_HUMANANXA1_HUMANIntAct14743216 details
IKBA_HUMANTBA3C_HUMANIntAct14743216 details
IKBA_HUMANTBA3D_HUMANIntAct14743216 details
IKBA_HUMANTBA1A_HUMANIntAct14743216 details
IKBA_HUMANRELB_HUMANBioGRID, IntAct14743216 19219072 26186194 27609421 28514442 details
IKBA_HUMANMCM5_HUMANHPRD, IntAct14743216 details
IKBA_HUMANMCM7_HUMANHPRD, IntAct14743216 details
IKBA_HUMANCSN2_HUMANBioGRID, MINT17318178 details
IKBA_HUMANUBC_HUMANMINT17318178 18539148 details
IKBA_HUMANTGM2_HUMANBioGRID, IntAct16951195 23185316 details
IKBA_HUMANCOMD1_HUMANBioGRID, HPRD, IntAct14685242 16573520 20068069 25520503 details
IKBA_HUMANRS3_HUMANBioGRID, IntAct, MINT18045535 24457201 32555320 details
IKBA_HUMANCUL1_HUMANBioGRID, HPRD, MINT10066435 10713156 11027288 11483504 14743216 17914462 22590978 29499133 details
IKBA_HUMANPHS_HUMANIntAct20195357 details
IKBA_HUMANRAN_HUMANIntAct24855949 details
IKBA_HUMANSRC_HUMANBioGRID, HPRD, IntAct12429743 26186194 28514442 8797825 9792645 details
IKBA_HUMANCTNA1_HUMANDIP24509793 details
IKBA_HUMANPSA4_HUMANBioGRID, DIP24509793 9875328 details
IKBA_HUMANEP300_HUMANBioGRID, IntAct19456861 21483817 details
IKBA_HUMANNCOR2_HUMANBioGRID, HPRD12589049 15536134 details
IKBA_HUMANHDAC3_HUMANBioGRID, HPRD12972430 16371367 details
IKBA_HUMANNCOR1_HUMANBioGRID15536134 details
IKBA_HUMANHDAC1_HUMANBioGRID, HPRD12972430 15536134 details
IKBA_HUMANHDAC2_HUMANBioGRID15536134 details
IKBA_HUMANHDAC4_HUMANBioGRID15536134 details
IKBA_HUMANHDAC5_HUMANBioGRID15536134 details
IKBA_HUMANCLUS_HUMANBioGRID20068069 details
IKBA_HUMANMALT1_HUMANBioGRID20551178 details
IKBA_HUMANBCL10_HUMANBioGRID20551178 details
IKBA_HUMANKC1A_HUMANBioGRID20551178 details
IKBA_HUMANHNRPU_HUMANBioGRID20797629 details
IKBA_HUMANMK14_HUMANBioGRID20797629 details
IKBA_HUMANFBXW8_HUMANBioGRID20558726 details
IKBA_HUMANRB6I2_HUMANBioGRID15218148 details
IKBA_HUMANPIN1_HUMANBioGRID14690596 details
IKBA_HUMANSOCS3_HUMANBioGRID21451109 details
IKBA_HUMANZBT7A_HUMANBioGRID15917220 details
IKBA_HUMANPSA1_HUMANBioGRID23393163 details
IKBA_HUMANSTAT1_HUMANBioGRID16481475 details
IKBA_HUMANCSN1_HUMANBioGRID23818606 details
IKBA_HUMANCSN3_HUMANBioGRID23818606 details
IKBA_HUMANUFD1_HUMANBioGRID24248593 details
IKBA_HUMANNPL4_HUMANBioGRID24248593 details
IKBA_HUMANMTOR_HUMANBioGRID18519641 details
IKBA_HUMANMAVS_HUMANBioGRID25636800 details
IKBA_HUMANRN183_HUMANBioGRID26818663 details
IKBA_HUMANRN121_HUMANBioGRID25388546 details
IKBA_HUMANAKT1_HUMANBioGRID11278366 details
IKBA_HUMANASB2_HUMANBioGRID30116272 details
IKBA_HUMANRBBP6_HUMANBioGRID31685801 details
IKBA_HUMANVIME_HUMANBioGRID22536447 details
IKBA_HUMANFBXW7_HUMANBioGRID31945730 details
IKBA_HUMANHECD1_HUMANBioGRID32555320 details
IKBA_HUMANSUMO1_HUMANHPRD9734360 details
IKBA_HUMANCSK21_HUMANHPRD10398585 8622692 details
IKBA_HUMANKBRS1_HUMANHPRD10657303 details
IKBA_HUMANJAK2_HUMANHPRD11493922 details
IKBA_HUMANKPCI_HUMANHPRD10848576 details
IKBA_HUMANM3K3_HUMANHPRD10085062 details
IKBA_HUMANKBRS2_HUMANHPRD10657303 details
IKBA_HUMANHSPB1_HUMANHPRD12897149 details
IKBA_HUMANM3K2_HUMANHPRD10085062 details
IKBA_HUMANCSN8_HUMANHPRD17318178 details
IKBA_HUMANCAN2_HUMANHPRD9873017 details
IKBA_HUMANHXA9_HUMANHPRD15161102 details
IKBA_HUMANLCK_HUMANHPRD12429743 8797825 9792645 details
IKBA_HUMANE2AK2_HUMANHPRD10723127 8601309 9214631 9721103 details
IKBA_HUMANTBA1B_HUMANHPRD9372968 details
IKBA_HUMANTNF11_HUMANHPRD10635328 details