Entity Details

Primary name DPP4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP27487
EntryNameDPP4_HUMAN
FullNameDipeptidyl peptidase 4
TaxID9606
Evidenceevidence at protein level
Length766
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesDPP4

GO terms

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GOName
GO:0001618 virus receptor activity
GO:0001662 behavioral fear response
GO:0001666 response to hypoxia
GO:0002020 protease binding
GO:0004177 aminopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006508 proteolysis
GO:0007155 cell adhesion
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0008284 positive regulation of cell population proliferation
GO:0009986 cell surface
GO:0010716 negative regulation of extracellular matrix disassembly
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0030027 lamellipodium
GO:0030139 endocytic vesicle
GO:0031258 lamellipodium membrane
GO:0031295 T cell costimulation
GO:0033632 regulation of cell-cell adhesion mediated by integrin
GO:0035641 locomotory exploration behavior
GO:0036343 psychomotor behavior
GO:0042110 T cell activation
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043542 endothelial cell migration
GO:0045121 membrane raft
GO:0045499 chemorepellent activity
GO:0046581 intercellular canaliculus
GO:0050796 regulation of insulin secretion
GO:0070062 extracellular exosome
GO:0090024 negative regulation of neutrophil chemotaxis

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell junction
Cell membrane
Cell projection
Membrane raft
Secreted

Domains

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DomainNameCategoryType
IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domainDomainDomain
IPR002469 Dipeptidylpeptidase IV, N-terminal domainDomainDomain
IPR002471 Peptidase S9, serine active siteSiteActive site
IPR029058 Alpha/Beta hydrolase foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01076 AtorvastatinDrugbanksmall molecule
DB01261 SitagliptinDrugbanksmall molecule
DB01276 ExenatideDrugbankbiotech
DB01884 2-Amino-3-Methyl-1-Pyrrolidin-1-Yl-Butan-1-OneDrugbanksmall molecule
DB02004 5-(Aminomethyl)-6-(2,4-Dichlorophenyl)-2-(3,5-Dimethoxyphenyl)Pyrimidin-4-AmineDrugbanksmall molecule
DB03253 (2s)-Pyrrolidin-2-YlmethylamineDrugbanksmall molecule
DB03660 4-Iodo-L-phenylalanineDrugbanksmall molecule
DB04491 Diisopropylphosphono GroupDrugbanksmall molecule
DB04577 1-(1-phenylcyclopentyl)methylamineDrugbanksmall molecule
DB04578 (S)-2-[(R)-3-amino-4-(2-fluorophenyl)butyryl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamideDrugbanksmall molecule
DB04876 VildagliptinDrugbanksmall molecule
DB05001 PSN9301Drugbanksmall molecule
DB06011 AMG-222Drugbanksmall molecule
DB06127 BisegliptinDrugbanksmall molecule
DB06203 AlogliptinDrugbanksmall molecule
DB06335 SaxagliptinDrugbanksmall molecule
DB06655 LiraglutideDrugbankbiotech
DB06880 (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-PROP-1-YN-1-YLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINEDrugbanksmall molecule
DB06939 N-(TRANS-4-{(1S,2S)-2-AMINO-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-1-METHYL-3-OXOPROPYL}CYCLOHEXYL)-N-METHYLACETAMIDEDrugbanksmall molecule
DB06993 (2S,3S)-4-cyclopropyl-3-{(3R,5R)-3-[2-fluoro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazolidin-5-yl}-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amineDrugbanksmall molecule
DB06994 (2S,3S)-3-{3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-cyclopentylidene-4-cyclopropyl-1-fluorobutan-2-amineDrugbanksmall molecule
DB07015 (3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinoxalin-2-ylcarbonyl)pyrrolidin-3-amineDrugbanksmall molecule
DB07021 (7R,8R)-8-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydroimidazo[1,2-a:4,5-c']dipyridin-7-amineDrugbanksmall molecule
DB07067 (2S,3S)-3-{3-[4-(METHYLSULFONYL)PHENYL]-1,2,4-OXADIAZOL-5-YL}-1-OXO-1-PYRROLIDIN-1-YLBUTAN-2-AMINEDrugbanksmall molecule
DB07072 (1S,2R,5S)-5-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-2-(2,4,5-TRIFLUOROPHENYL)CYCLOHEXANAMINEDrugbanksmall molecule
DB07081 (2R)-4-[(8R)-8-METHYL-2-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRAZIN-7(8H)-YL]-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINEDrugbanksmall molecule
DB07092 (2S,3S)-3-AMINO-4-(3,3-DIFLUOROPYRROLIDIN-1-YL)-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-6-YLCYCLOHEXYL)BUTANAMIDEDrugbanksmall molecule
DB07135 (2S,3S)-3-AMINO-4-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-5-YLCYCLOHEXYL)BUTANAMIDEDrugbanksmall molecule
DB07154 (3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-METHYL-1,4-DIAZEPAN-2-ONEDrugbanksmall molecule
DB07181 4'-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]biphenyl-3-carboxamideDrugbanksmall molecule
DB07193 (2R,3R)-7-(methylsulfonyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amineDrugbanksmall molecule
DB07239 7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1H-benzimidazole-5-carbonitrileDrugbanksmall molecule
DB07271 4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-oneDrugbanksmall molecule
DB07328 METHYL 4-{[({[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHYL}AMINO)CARBONYL]AMINO}BENZOATEDrugbanksmall molecule
DB07356 (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINEDrugbanksmall molecule
DB07412 1-biphenyl-2-ylmethanamineDrugbanksmall molecule
DB07465 (1S,3S,5S)-2-{(2S)-2-amino-2-[(1R,3S,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]dec-1-yl]acetyl}-2-azabicyclo[3.1.0]hexane-3-carbonitrileDrugbanksmall molecule
DB07482 (2R)-N-[(2R)-2-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-N-[(5R)-5-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-L-PROLINAMIDEDrugbanksmall molecule
DB07666 (3R,4S)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINEDrugbanksmall molecule
DB07779 N-({(2S)-1-[(3R)-3-AMINO-4-(2-FLUOROPHENYL)BUTANOYL]PYRROLIDIN-2-YL}METHYL)BENZAMIDEDrugbanksmall molecule
DB07830 (4R,5R)-5-AMINO-1-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-2-ONEDrugbanksmall molecule
DB07851 (3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINEDrugbanksmall molecule
DB08024 1-[2-(S)-AMINO-3-BIPHENYL-4-YL-PROPIONYL]-PYRROLIDINE-2-(S)-CARBONITRILEDrugbanksmall molecule
DB08044 ABT-341Drugbanksmall molecule
DB08051 (2R)-4-(2-BENZOYL-1,2-DIAZEPAN-1-YL)-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINEDrugbanksmall molecule
DB08164 (3R,4R)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-3-AMINEDrugbanksmall molecule
DB08382 GosogliptinDrugbanksmall molecule
DB08429 N-({(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl}methyl)-3-(methylsulfonyl)benzamideDrugbanksmall molecule
DB08445 (3R,4S)-1-[6-(6-METHOXYPYRIDIN-3-YL)PYRIMIDIN-4-YL]-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINEDrugbanksmall molecule
DB08504 6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUMDrugbanksmall molecule
DB08530 7-BENZYL-1,3-DIMETHYL-8-PIPERAZIN-1-YL-3,7-DIHYDRO-PURINE-2,6-DIONEDrugbanksmall molecule
DB08588 2-({2-[(3R)-3-AMINOPIPERIDIN-1-YL]-4-OXOQUINAZOLIN-3(4H)-YL}METHYL)BENZONITRILEDrugbanksmall molecule
DB08672 4-[(3R)-3-{[2-(4-FLUOROPHENYL)-2-OXOETHYL]AMINO}BUTYL]BENZAMIDEDrugbanksmall molecule
DB08743 2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILEDrugbanksmall molecule
DB08882 LinagliptinDrugbanksmall molecule
DB11723 DutogliptinDrugbanksmall molecule
DB13928 SemaglutideDrugbanksmall molecule

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
DPP4_HUMANPACA_HUMANMINT21314817 details
DPP4_HUMANANFB_HUMANMINT21314817 details
DPP4_HUMANDPP4_HUMANHPRD, MINT11696365 22001206 details
DPP4_HUMANSDF1_HUMANHPRD, MINT11390394 18275857 21314817 details
DPP4_HUMANCXL11_HUMANHPRD, MINT11390394 18275857 21314817 details
DPP4_HUMANDKK1_HUMANBioGRID, IntAct21988832 details
DPP4_HUMANCCL5_HUMANHPRD, MINT11390394 21314817 9516414 details
DPP4_HUMANCXL10_HUMANHPRD, MINT11390394 18275857 21314817 details
DPP4_HUMANCXCL9_HUMANHPRD, MINT11390394 18275857 21314817 details
DPP4_HUMANCCL22_HUMANBioGRID, HPRD, MINT11390394 21314817 9933589 details
DPP4_HUMANCCL11_HUMANHPRD, MINT11390394 18275857 21314817 details
DPP4_HUMANGIP_HUMANMINT21314817 details
DPP4_HUMANGCP2_HUMANMINT18275857 details
DPP4_HUMANGLUC_HUMANMINT21314817 details
DPP4_HUMANNPY_HUMANMINT21314817 details
DPP4_HUMANTKN1_HUMANMINT21314817 details
DPP4_HUMANCXCL2_HUMANMINT18275857 21314817 details
DPP4_HUMANVIP_HUMANMINT21314817 details
DPP4_HUMANSLIB_HUMANMINT21314817 details
DPP4_HUMANPYY_HUMANMINT21314817 details
DPP4_HUMANBCL10_HUMANBioGRID17287217 details
DPP4_HUMANCD4_HUMANHPRD7539755 details
DPP4_HUMANSEPR_HUMANBioGRID, HPRD26209915 7911242 details
DPP4_HUMANADA_HUMANBioGRID, HPRD11772392 26209915 details
DPP4_HUMANCAR11_HUMANBioGRID17287217 details
DPP4_HUMANPTPRC_HUMANHPRD1680916 details
DPP4_HUMANCL3L1_HUMANHPRD10961862 11390394 details
DPP4_HUMANUBP22_HUMANBioGRID30197002 details
DPP4_HUMANGRP_HUMANHPRD11696365 details
DPP4_HUMANCXCR4_HUMANHPRD11278278 details
DPP4_HUMANIKKB_HUMANBioGRID17287217 details