Entity Details

Primary name DHI1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28845
EntryNameDHI1_HUMAN
FullNameCorticosteroid 11-beta-dehydrogenase isozyme 1
TaxID9606
Evidenceevidence at protein level
Length292
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesHSD11B1

GO terms

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GOName
GO:0030324 lung development
GO:0005789 endoplasmic reticulum membrane
GO:0070524 11-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO:0005496 steroid binding
GO:0042803 protein homodimerization activity
GO:0050661 NADP binding
GO:0006704 glucocorticoid biosynthetic process
GO:0006706 steroid catabolic process
GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0016020 membrane

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR002347 Short-chain dehydrogenase/reductase SDRFamilyFamily
IPR020904 Short-chain dehydrogenase/reductase, conserved siteSiteConserved site
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00461 NabumetoneDrugbanksmall molecule
DB00635 PrednisoneDrugbanksmall molecule
DB00687 FludrocortisoneDrugbanksmall molecule
DB00741 HydrocortisoneDrugbanksmall molecule
DB00959 MethylprednisoloneDrugbanksmall molecule
DB01234 DexamethasoneDrugbanksmall molecule
DB02329 CarbenoxoloneDrugbanksmall molecule
DB03461 Nicotinamide adenine dinucleotide phosphateDrugbanksmall molecule
DB03814 2-(N-morpholino)ethanesulfonic acidDrugbanksmall molecule
DB04652 CorticosteroneDrugbanksmall molecule
DB05064 INCB13739Drugbanksmall molecule
DB06992 (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanoneDrugbanksmall molecule
DB07017 (5S)-2-{[(1S)-1-(4-Fluorophenyl)ethyl]amino}-5-(2-hydroxy-2-propanyl)-5-methyl-1,3-thiazol-4(5H)-oneDrugbanksmall molecule
DB07049 (2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazineDrugbanksmall molecule
DB07056 2-(6-{[(3-chloro-2-methylphenyl)sulfonyl]amino}pyridin-2-yl)-N,N-diethylacetamideDrugbanksmall molecule
DB07310 (5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-oneDrugbanksmall molecule
DB07316 N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamideDrugbanksmall molecule
DB07619 N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamideDrugbanksmall molecule
DB07624 1-{[(3R)-3-methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamideDrugbanksmall molecule
DB07866 (5S)-2-(Cyclooctylamino)-5-methyl-5-propyl-1,3-thiazol-4(5H)-oneDrugbanksmall molecule
DB08277 2-(2-CHLORO-4-FLUOROPHENOXY)-2-METHYL-N-[(1R,2S,3S,5S,7S)-5-(METHYLSULFONYL)-2-ADAMANTYL]PROPANAMIDEDrugbanksmall molecule
DB08280 (1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDEDrugbanksmall molecule
DB08771 (5R)-2-[(2-Fluorophenyl)amino]-5-isopropyl-1,3-thiazol-4(5H)-oneDrugbanksmall molecule
DB13751 Glycyrrhizic acidDrugbanksmall molecule
DB14631 Prednisolone phosphateDrugbanksmall molecule
DB14649 Dexamethasone acetateDrugbanksmall molecule
DB15093 SomapacitanDrugbankbiotech

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
DHI1_HUMANGKAP1_HUMANBioGRID, IntAct21988832 details
DHI1_HUMANCD36_HUMANBioGRID9555943 details
DHI1_HUMANDHI1_HUMANDIP21325058 details