Entity Details

Primary name EPHB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29323
EntryNameEPHB2_HUMAN
FullNameEphrin type-B receptor 2
TaxID9606
Evidenceevidence at protein level
Length1055
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesEPHB2

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001540 amyloid-beta binding
GO:0001655 urogenital system development
GO:0001933 negative regulation of protein phosphorylation
GO:0002639 positive regulation of immunoglobulin production
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007162 negative regulation of cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007413 axonal fasciculation
GO:0007611 learning or memory
GO:0007612 learning
GO:0008046 axon guidance receptor activity
GO:0010628 positive regulation of gene expression
GO:0016310 phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021631 optic nerve morphogenesis
GO:0021952 central nervous system projection neuron axonogenesis
GO:0022038 corpus callosum development
GO:0030193 regulation of blood coagulation
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0030425 dendrite
GO:0030890 positive regulation of B cell proliferation
GO:0031290 retinal ganglion cell axon guidance
GO:0031915 positive regulation of synaptic plasticity
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033674 positive regulation of kinase activity
GO:0042113 B cell activation
GO:0042472 inner ear morphogenesis
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0044877 protein-containing complex binding
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048013 ephrin receptor signaling pathway
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048170 positive regulation of long-term neuronal synaptic plasticity
GO:0048593 camera-type eye morphogenesis
GO:0050771 negative regulation of axonogenesis
GO:0050878 regulation of body fluid levels
GO:0051389 obsolete inactivation of MAPKK activity
GO:0051965 positive regulation of synapse assembly
GO:0060021 roof of mouth development
GO:0060996 dendritic spine development
GO:0060997 dendritic spine morphogenesis
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071679 commissural neuron axon guidance
GO:0097104 postsynaptic membrane assembly
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0099055 integral component of postsynaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:0099557 trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
GO:0106028 neuron projection retraction
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1904782 negative regulation of NMDA glutamate receptor activity
GO:1904783 positive regulation of NMDA glutamate receptor activity

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001090 Ephrin receptor ligand binding domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001426 Tyrosine-protein kinase, receptor class V, conserved siteSiteConserved site
IPR001660 Sterile alpha motif domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-likeDomainDomain
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016257 Ephrin receptor type-A /type-BFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR027936 Ephrin receptor, transmembrane domainDomainDomain
IPR034238 Ephrin type-B receptor 2, ligand binding domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
EPHB2_HUMANAFAD_HUMANBioGRID, MINT9707552 details
EPHB2_HUMANNU153_HUMANMINT17255949 details
EPHB2_HUMANEFNB2_HUMANBioGRID, HPRD, IntAct11780069 26186194 28514442 details
EPHB2_HUMANMTMRE_HUMANBioGRID, MINT28065597 details
EPHB2_HUMANTRI54_HUMANBioGRID, IntAct31391242 details
EPHB2_HUMANCOMT_HUMANIntAct32814053 details
EPHB2_HUMANPAHX_HUMANIntAct32814053 details
EPHB2_HUMANCLN6_HUMANIntAct32814053 details
EPHB2_HUMANJPH3_HUMANIntAct32814053 details
EPHB2_HUMANSPRE1_HUMANIntAct32814053 details
EPHB2_HUMANTADBP_HUMANIntAct32814053 details
EPHB2_HUMANSRC_HUMANBioGRID, HPRD10644995 18713744 9632142 details
EPHB2_HUMANRASA1_HUMANBioGRID, HPRD10644995 9233798 details
EPHB2_HUMANCRK_HUMANBioGRID10644995 details
EPHB2_HUMANEPHB2_HUMANBioGRID, HPRD10572014 17192257 18797457 9233798 9632142 9933164 details
EPHB2_HUMANYES_HUMANBioGRID9632142 details
EPHB2_HUMANPLCG1_HUMANBioGRID9632142 details
EPHB2_HUMANABL1_HUMANBioGRID, HPRD11494128 details
EPHB2_HUMANABL2_HUMANBioGRID, HPRD11494128 details
EPHB2_HUMANFBX7_HUMANBioGRID27503909 details
EPHB2_HUMANERBB2_HUMANBioGRID30898150 details
EPHB2_HUMANSDCB1_HUMANHPRD9883737 details
EPHB2_HUMANPICK1_HUMANHPRD10839360 9883737 details
EPHB2_HUMANRBL1_HUMANIntAct17353931 details
EPHB2_HUMANTP4A2_HUMANIntAct17353931 details
EPHB2_HUMANMK14_HUMANMINT17255949 details
EPHB2_HUMANPPAC_HUMANBioGRID, HPRD9499402 details
EPHB2_HUMANRYK_HUMANBioGRID, HPRD11956217 details
EPHB2_HUMANITSN1_HUMANBioGRID, HPRD12389031 details
EPHB2_HUMANALK_HUMANBioGRID14968112 details
EPHB2_HUMANHMMR_HUMANBioGRID22610405 details
EPHB2_HUMANSPSB4_HUMANBioGRID28931592 details
EPHB2_HUMANSPSB1_HUMANBioGRID28931592 details
EPHB2_HUMANNMDZ1_HUMANBioGRID, HPRD11754835 22544902 details
EPHB2_HUMANRRAS_HUMANHPRD10570155 details
EPHB2_HUMANEFNB1_HUMANHPRD8878483 details
EPHB2_HUMANNCK1_HUMANHPRD9233798 details
EPHB2_HUMANERF_HUMANHPRD10330152 details
EPHB2_HUMANEFNA5_HUMANHPRD15107857 details
EPHB2_HUMANSYNJ1_HUMANHPRD15821731 details
EPHB2_HUMANSH2D3_HUMANHPRD10542222 details
EPHB2_HUMANNMDE2_HUMANHPRD11799243 details
EPHB2_HUMANSDC2_HUMANHPRD11580899 details
EPHB2_HUMANVAV2_HUMANHPRD15848800 details
EPHB2_HUMANKALRN_HUMANHPRD12546821 details
EPHB2_HUMANARHG6_HUMANHPRD10523848 details
EPHB2_HUMANGRB2_HUMANHPRD16298995 details
EPHB2_HUMANVEGFA_HUMANHPRD17318185 details
EPHB2_HUMANKSR1_HUMANHPRD11940661 details
EPHB2_HUMANMMP2_HUMANHPRD18713744 details
EPHB2_HUMANMMP9_HUMANHPRD18713744 details
EPHB2_HUMANFOS_HUMANHPRD12972619 7816602 details