Entity Details

Primary name SPRE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35270
EntryNameSPRE_HUMAN
FullNameSepiapterin reductase
TaxID9606
Evidenceevidence at protein level
Length261
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesSPR

GO terms

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GOName
GO:0004033 aldo-keto reductase (NADP) activity
GO:0004757 sepiapterin reductase activity
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006729 tetrahydrobiopterin biosynthetic process
GO:0006809 nitric oxide biosynthetic process
GO:0046146 tetrahydrobiopterin metabolic process
GO:0050661 NADP binding
GO:0050999 regulation of nitric-oxide synthase activity
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR002347 Short-chain dehydrogenase/reductase SDRFamilyFamily
IPR006393 Sepiapterin reductaseFamilyFamily
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02637 Oxaloacetate IonDrugbanksmall molecule
DB03461 Nicotinamide adenine dinucleotide phosphateDrugbanksmall molecule
DB03886 BiopterinDrugbanksmall molecule
DB04275 N-acetylserotoninDrugbanksmall molecule

Interactions

3 interactions