Entity Details

Primary name MSH2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43246
EntryNameMSH2_HUMAN
FullNameDNA mismatch repair protein Msh2
TaxID9606
Evidenceevidence at protein level
Length934
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesMSH2

GO terms

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GOName
GO:0000406 double-strand/single-strand DNA junction binding
GO:0000781 chromosome, telomeric region
GO:0001701 in utero embryonic development
GO:0002204 somatic recombination of immunoglobulin genes involved in immune response
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006119 oxidative phosphorylation
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006301 postreplication repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0007281 germ cell development
GO:0008022 protein C-terminus binding
GO:0008094 ATPase, acting on DNA
GO:0008340 determination of adult lifespan
GO:0008584 male gonad development
GO:0010165 response to X-ray
GO:0010224 response to UV-B
GO:0016020 membrane
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0019237 centromeric DNA binding
GO:0019724 B cell mediated immunity
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030183 B cell differentiation
GO:0031573 mitotic intra-S DNA damage checkpoint signaling
GO:0032137 guanine/thymine mispair binding
GO:0032300 mismatch repair complex
GO:0032301 MutSalpha complex
GO:0032302 MutSbeta complex
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042803 protein homodimerization activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043570 maintenance of DNA repeat elements
GO:0045190 isotype switching
GO:0045910 negative regulation of DNA recombination
GO:0048298 positive regulation of isotype switching to IgA isotypes
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0051096 positive regulation of helicase activity
GO:0071168 protein localization to chromatin

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR000432 DNA mismatch repair protein MutS, C-terminalDomainDomain
IPR007695 DNA mismatch repair protein MutS-like, N-terminalDomainDomain
IPR007696 DNA mismatch repair protein MutS, coreDomainDomain
IPR007860 DNA mismatch repair protein MutS, connector domainDomainDomain
IPR007861 DNA mismatch repair protein MutS, clampDomainDomain
IPR011184 DNA mismatch repair Msh2-typeFamilyFamily
IPR016151 DNA mismatch repair protein MutS, N-terminalFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032642 DNA mismatch repair protein Msh2FamilyFamily
IPR036187 DNA mismatch repair protein MutS, core domain superfamilyFamilyHomologous superfamily
IPR036678 MutS, connector domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

91 interactions

InteractorPartnerSourcesPublicationsLink
MSH2_HUMANEXO1_HUMANBioGRID, HPRD, IntAct, UniProt10856833 11427529 11429708 12414623 14676842 19015241 22222486 9788596 details
MSH2_HUMANMSH6_HUMANBioGRID, DIP, HPRD, IntAct10029069 10748159 10783165 10856833 14657349 15064730 19377479 22939629 25241761 26344197 26496610 8942985 9428522 9774676 details
MSH2_HUMANMSH3_HUMANBioGRID, DIP, HPRD, IntAct10029069 14657349 16025128 19377479 22179786 22939629 8805365 8942985 9774676 details
MSH2_HUMANMSH2_HUMANBioGRID, IntAct8942985 9774676 details
MSH2_HUMANMYC_HUMANBioGRID, IntAct12584560 17314511 28205554 29467282 30415952 details
MSH2_HUMANSLX4_HUMANBioGRID, IntAct19596235 22902628 31495888 32398829 details
MSH2_HUMANANXA7_HUMANBioGRID, MINT21900206 details
MSH2_HUMANCDN1A_HUMANBioGRID, MINT21900206 details
MSH2_HUMANGRB7_HUMANBioGRID, MINT21900206 details
MSH2_HUMANRPP14_HUMANBioGRID, MINT21900206 details
MSH2_HUMANSMN_HUMANBioGRID, MINT21900206 details
MSH2_HUMANKITH_HUMANBioGRID, MINT21900206 details
MSH2_HUMANMAX_HUMANBioGRID, HPRD, IntAct12584560 25241761 details
MSH2_HUMANAKT1_HUMANBioGRID, MINT24412244 28205554 details
MSH2_HUMANCC14B_HUMANBioGRID, MINT24412244 27880917 details
MSH2_HUMANDVL1_HUMANBioGRID, MINT24412244 details
MSH2_HUMANF16P1_HUMANBioGRID, MINT24412244 details
MSH2_HUMANF16P2_HUMANBioGRID, MINT24412244 details
MSH2_HUMANGLT12_HUMANBioGRID, MINT24412244 details
MSH2_HUMANRASH_HUMANBioGRID, MINT24412244 details
MSH2_HUMANCC180_HUMANBioGRID, MINT24412244 details
MSH2_HUMANLEF1_HUMANBioGRID, MINT24412244 details
MSH2_HUMANSMAD1_HUMANBioGRID, MINT24412244 details
MSH2_HUMANCANB2_HUMANBioGRID, MINT24412244 details
MSH2_HUMANSTX17_HUMANBioGRID, MINT24412244 details
MSH2_HUMANTDRD7_HUMANBioGRID, MINT24412244 details
MSH2_HUMANZN510_HUMANBioGRID, MINT24412244 details
MSH2_HUMANAPBP2_HUMANBioGRID, IntAct32296183 details
MSH2_HUMANBRCA1_HUMANBioGRID10783165 11498787 15886699 details
MSH2_HUMANBARD1_HUMANBioGRID, HPRD11498787 details
MSH2_HUMANCHK2_HUMANBioGRID, HPRD12447371 15647386 details
MSH2_HUMANATR_HUMANBioGRID, HPRD14657349 21285353 33005030 details
MSH2_HUMANPCNA_HUMANBioGRID, HPRD12171929 15225546 8858149 details
MSH2_HUMANXPA_HUMANBioGRID19468048 details
MSH2_HUMANRFA4_HUMANBioGRID19468048 details
MSH2_HUMANESR1_HUMANBioGRID15886699 details
MSH2_HUMANESR2_HUMANBioGRID15886699 29509190 details
MSH2_HUMANHUS1_HUMANBioGRID20188637 details
MSH2_HUMANRAD1_HUMANBioGRID20188637 details
MSH2_HUMANRAD9A_HUMANBioGRID20188637 details
MSH2_HUMANMUTYH_HUMANBioGRID11801590 details
MSH2_HUMANHDAC6_HUMANBioGRID23703321 24882211 details
MSH2_HUMANSUMO2_HUMANBioGRID19394292 25533185 32786267 details
MSH2_HUMANUBP10_HUMANBioGRID26975374 details
MSH2_HUMANTRI29_HUMANBioGRID26095369 details
MSH2_HUMANEPHA2_HUMANBioGRID28205554 details
MSH2_HUMANFGFR4_HUMANBioGRID28205554 details
MSH2_HUMANCDC42_HUMANBioGRID31478661 details
MSH2_HUMANNEMO_HUMANIntAct14743216 details
MSH2_HUMANCRCM_HUMANIntAct17353931 details
MSH2_HUMANARF6_HUMANIntAct17353931 details
MSH2_HUMANWRP73_HUMANIntAct17353931 details
MSH2_HUMANMLH1_HUMANBioGRID, IntAct10748159 10783165 12799449 25241761 30770470 31843968 details
MSH2_HUMANHMGB1_HUMANUniProt15014079 details
MSH2_HUMANRAF1_HUMANBioGRID, IntAct27173435 31980649 unassigned1312 details
MSH2_HUMANFTM_HUMANBioGRID, IntAct27173435 unassigned1312 details
MSH2_HUMANBLM_HUMANBioGRID10783165 15064730 details
MSH2_HUMANCHK1_HUMANBioGRID15647386 details
MSH2_HUMANATM_HUMANBioGRID10783165 details
MSH2_HUMANMRE11_HUMANBioGRID10783165 details
MSH2_HUMANNBN_HUMANBioGRID10783165 details
MSH2_HUMANRAD50_HUMANBioGRID10783165 details
MSH2_HUMANRFC1_HUMANBioGRID10783165 details
MSH2_HUMANATRIP_HUMANBioGRID, HPRD14657349 details
MSH2_HUMANPMS2_HUMANBioGRID10748159 12799449 17148452 details
MSH2_HUMANAIRE_HUMANBioGRID20085707 details
MSH2_HUMANKPCZ_HUMANBioGRID15808853 details
MSH2_HUMANMGMT_HUMANBioGRID16226712 details
MSH2_HUMANP53_HUMANBioGRID12101417 15064730 32807901 details
MSH2_HUMANCBP_HUMANBioGRID, HPRD16051665 details
MSH2_HUMANFANCA_HUMANBioGRID21975120 details
MSH2_HUMANDTL_HUMANBioGRID21725088 details
MSH2_HUMANSMRCD_HUMANBioGRID21549307 31843968 details
MSH2_HUMANCDK9_HUMANBioGRID20305087 27684187 details
MSH2_HUMANNELFB_HUMANBioGRID20305087 details
MSH2_HUMANPMS1_HUMANBioGRID10748159 details
MSH2_HUMANRAD51_HUMANBioGRID15064730 details
MSH2_HUMANXRCC6_HUMANBioGRID21075794 22863883 details
MSH2_HUMANFACD2_HUMANBioGRID21865299 details
MSH2_HUMANERCC1_HUMANBioGRID14706347 details
MSH2_HUMANXPF_HUMANBioGRID14706347 details
MSH2_HUMANPOLK_HUMANBioGRID24038355 details
MSH2_HUMANREV1_HUMANBioGRID24038355 details
MSH2_HUMANSIR6_HUMANBioGRID24169447 details
MSH2_HUMANRN126_HUMANBioGRID26508657 details
MSH2_HUMANMCM9_HUMANBioGRID26300262 26870752 details
MSH2_HUMANMCM8_HUMANBioGRID26300262 details
MSH2_HUMANRAD18_HUMANBioGRID27377895 details
MSH2_HUMANH2AX_HUMANBioGRID26095369 details
MSH2_HUMANLRC31_HUMANBioGRID33005030 details
MSH2_HUMANSMC1A_HUMANHPRD14657349 details