Entity Details

Primary name NSF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP46459
EntryNameNSF_HUMAN
FullNameVesicle-fusing ATPase
TaxID9606
Evidenceevidence at protein level
Length744
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesNSF

GO terms

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GOName
GO:0000149 SNARE binding
GO:0001921 positive regulation of receptor recycling
GO:0005524 ATP binding
GO:0005765 lysosomal membrane
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006813 potassium ion transport
GO:0006886 intracellular protein transport
GO:0006887 exocytosis
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO:0006891 intra-Golgi vesicle-mediated transport
GO:0014069 postsynaptic density
GO:0016192 vesicle-mediated transport
GO:0016887 ATP hydrolysis activity
GO:0017075 syntaxin-1 binding
GO:0017157 regulation of exocytosis
GO:0019901 protein kinase binding
GO:0030165 PDZ domain binding
GO:0035255 ionotropic glutamate receptor binding
GO:0035494 SNARE complex disassembly
GO:0043001 Golgi to plasma membrane protein transport
GO:0043198 dendritic shaft
GO:0044877 protein-containing complex binding
GO:0045026 plasma membrane fusion
GO:0045732 positive regulation of protein catabolic process
GO:0046872 metal ion binding
GO:0048208 COPII vesicle coating
GO:0048211 Golgi vesicle docking

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR003338 CDC48, N-terminal subdomainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR003959 ATPase, AAA-type, coreDomainDomain
IPR003960 ATPase, AAA-type, conserved siteSiteConserved site
IPR004201 CDC48, domain 2DomainDomain
IPR009010 Aspartate decarboxylase-like domain superfamilyFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR029067 CDC48 domain 2-like superfamilyFamilyHomologous superfamily
IPR039812 Vesicle-fusing ATPaseFamilyFamily
IPR041569 AAA ATPase, AAA+ lid domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01902 1-Ethyl-Pyrrolidine-2,5-DioneDrugbanksmall molecule

Interactions

43 interactions

InteractorPartnerSourcesPublicationsLink
NSF_HUMANERG28_HUMANBioGRID, HPRD, IntAct16169070 details
NSF_HUMANRLA1_HUMANBioGRID, HPRD, IntAct16169070 details
NSF_HUMANCE126_HUMANBioGRID, HPRD, IntAct16169070 details
NSF_HUMANLC7L2_HUMANBioGRID, HPRD, IntAct16169070 details
NSF_HUMANFUND2_HUMANBioGRID, HPRD, IntAct16169070 details
NSF_HUMANEIF3E_HUMANBioGRID, HPRD, IntAct16169070 details
NSF_HUMANGABR2_HUMANHPRD, MINT16724110 details
NSF_HUMANGRIA2_HUMANBioGRID, HPRD, MINT12130635 16724110 9697855 details
NSF_HUMANGABR1_HUMANHPRD, MINT16724110 details
NSF_HUMANPTPRC_HUMANIntAct19167335 details
NSF_HUMANPTPRK_HUMANIntAct19167335 details
NSF_HUMANPTPRG_HUMANIntAct19167335 details
NSF_HUMANPTPRB_HUMANIntAct19167335 details
NSF_HUMANPTPRJ_HUMANIntAct19167335 details
NSF_HUMANPTPRO_HUMANIntAct19167335 details
NSF_HUMANPTN12_HUMANIntAct19167335 details
NSF_HUMANSNAA_HUMANBioGRID, HPRD, IntAct, MINT15322554 20562859 30833792 7622514 9362506 details
NSF_HUMANNSF_HUMANBioGRID, HPRD, IntAct20562859 8051214 details
NSF_HUMANSNAG_HUMANBioGRID, HPRD, IntAct12554740 20562859 details
NSF_HUMANFER_HUMANMINT15322554 details
NSF_HUMANFES_HUMANMINT15322554 details
NSF_HUMANPTN9_HUMANHPRD, MINT15322554 details
NSF_HUMANESR1_HUMANBioGRID, IntAct20348541 31527615 details
NSF_HUMANARRB1_HUMANBioGRID, HPRD10196135 details
NSF_HUMANRAMP3_HUMANBioGRID15613468 details
NSF_HUMANASPC1_HUMANBioGRID25078495 details
NSF_HUMANMEOX2_HUMANBioGRID32296183 details
NSF_HUMANGRIA3_HUMANHPRD9697855 details
NSF_HUMANNEK6_HUMANIntAct17353931 details
NSF_HUMANSTX8_HUMANBioGRID, HPRD, IntAct10683148 20562859 details
NSF_HUMANGOSR1_HUMANBioGRID, HPRD, IntAct20562859 8636227 9325254 details
NSF_HUMANEXOC5_HUMANBioGRID, IntAct27173435 unassigned1312 details
NSF_HUMANEEA1_HUMANBioGRID10458612 details
NSF_HUMANGLUT4_HUMANBioGRID16396496 details
NSF_HUMANAKT1_HUMANBioGRID16027165 details
NSF_HUMANSTX4_HUMANBioGRID, HPRD34079125 8973549 details
NSF_HUMANGBRAP_HUMANHPRD11461150 details
NSF_HUMANVAPA_HUMANHPRD11511104 details
NSF_HUMANGBRL2_HUMANHPRD10747018 details
NSF_HUMANUSO1_HUMANHPRD10903204 details
NSF_HUMANSTX1A_HUMANHPRD7622514 details
NSF_HUMANCD28_HUMANHPRD11680900 details
NSF_HUMANDRD2_HUMANHPRD15858065 details