Entity Details

Primary name GNAS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP63092
EntryNameGNAS2_HUMAN
FullNameGuanine nucleotide-binding protein G(s) subunit alpha isoforms short
TaxID9606
Evidenceevidence at protein level
Length394
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesGNAS

GO terms

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GOName
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003091 renal water homeostasis
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007608 sensory perception of smell
GO:0010856 adenylate cyclase activator activity
GO:0016020 membrane
GO:0031224 intrinsic component of membrane
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0032588 trans-Golgi network membrane
GO:0043547 positive regulation of GTPase activity
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0046872 metal ion binding
GO:0046907 intracellular transport
GO:0048589 developmental growth
GO:0050796 regulation of insulin secretion
GO:0050890 cognition
GO:0060348 bone development
GO:0060789 hair follicle placode formation
GO:0070062 extracellular exosome
GO:0070527 platelet aggregation
GO:0071377 cellular response to glucagon stimulus
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071870 cellular response to catecholamine stimulus
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0120162 positive regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000367 G-protein alpha subunit, group SFamilyFamily
IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunitFamilyFamily
IPR011025 G protein alpha subunit, helical insertionFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02587 ColforsinDrugbanksmall molecule
DB06843 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATEDrugbanksmall molecule

Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
GNAS2_HUMANADRB2_HUMANBioGRID, IntAct12036966 15782186 23798571 28734930 details
GNAS2_HUMANNUCB2_HUMANBioGRID21988832 details
GNAS2_HUMANRIC8A_HUMANHPRD12652642 details
GNAS2_HUMANGBB1_HUMANBioGRID, IntAct15782186 26186194 28514442 details
GNAS2_HUMANRIC8B_HUMANBioGRID, HPRD, IntAct12652642 28514442 details
GNAS2_HUMANRGS2_HUMANBioGRID, HPRD9794454 details
GNAS2_HUMANCALM1_HUMANBioGRID15840729 details
GNAS2_HUMANPI2R_HUMANBioGRID, HPRD11895442 12488443 16114876 16352729 16460020 details
GNAS2_HUMANEGFR_HUMANBioGRID11185568 24797263 details
GNAS2_HUMANFZD7_HUMANBioGRID28298427 details
GNAS2_HUMANACM3_HUMANBioGRID, MINT28298427 details
GNAS2_HUMANNUCB1_HUMANBioGRID, HPRD21988832 9647645 details
GNAS2_HUMANCALM2_HUMANBioGRID15840729 details
GNAS2_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
GNAS2_HUMANDRD2_HUMANIntAct28734930 details
GNAS2_HUMANSNX13_HUMANBioGRID, HPRD11729322 details
GNAS2_HUMANGNAS3_HUMANBioGRID7797570 details
GNAS2_HUMANAXIN1_HUMANBioGRID16293724 details
GNAS2_HUMANRL3R1_HUMANBioGRID, MINT28298427 details
GNAS2_HUMANCHK2_HUMANBioGRID, MINT25640309 details
GNAS2_HUMANGNAS1_HUMANBioGRID, HPRD10598591 7797570 details
GNAS2_HUMANMSD3_HUMANBioGRID, MINT24412244 details
GNAS2_HUMANPANX1_HUMANBioGRID16293724 details
GNAS2_HUMANGNAS2_HUMANBioGRID, HPRD, IntAct10598591 17353931 7797570 details
GNAS2_HUMANDRD5_HUMANBioGRID9603210 details
GNAS2_HUMANCLTR2_HUMANBioGRID, MINT28298427 details
GNAS2_HUMANALEX_HUMANBioGRID7797570 details
GNAS2_HUMANV2R_HUMANBioGRID, HPRD15782186 8621513 details
GNAS2_HUMANOPTN_HUMANBioGRID20195357 details
GNAS2_HUMANGLP1R_HUMANBioGRID26272612 details
GNAS2_HUMANTA2R_HUMANBioGRID15782186 details
GNAS2_HUMANCALM3_HUMANBioGRID15840729 details
GNAS2_HUMANCNR1_HUMANIntAct28734930 details
GNAS2_HUMANTHIC_HUMANIntAct17353931 details
GNAS2_HUMANADRB3_HUMANHPRD8011597 details
GNAS2_HUMANGBG1_HUMANHPRD15368366 details
GNAS2_HUMANMAGD2_HUMANBioGRID, IntAct26186194 27120771 28514442 details
GNAS2_HUMANTTC1_HUMANBioGRID, HPRD12748287 details
GNAS2_HUMANLSHB_HUMANHPRD8663226 details
GNAS2_HUMANADCY6_HUMANHPRD9228084 details
GNAS2_HUMANTSHR_HUMANHPRD9525885 details
GNAS2_HUMANGLR_HUMANHPRD1908089 details
GNAS2_HUMANVIPR1_HUMANBioGRID, HPRD11812005 details
GNAS2_HUMANHLAA_HUMANBioGRID9914489 details
GNAS2_HUMANADCY2_HUMANBioGRID, HPRD, IntAct25241761 9268375 details
GNAS2_HUMANPD2R_HUMANHPRD12672054 details
GNAS2_HUMANMDM2_HUMANBioGRID18948082 details
GNAS2_HUMANGBG2_HUMANBioGRID20133939 details
GNAS2_HUMAN5HT6R_HUMANHPRD11916537 details
GNAS2_HUMANLSHR_HUMANHPRD10493819 details
GNAS2_HUMANADCY5_HUMANHPRD9268375 details
GNAS2_HUMANAA1R_HUMANHPRD10521440 details
GNAS2_HUMANCRFR1_HUMANBioGRID, HPRD10598591 details
GNAS2_HUMANPKHG2_HUMANBioGRID28489964 details
GNAS2_HUMANCD47_HUMANBioGRID21125662 details
GNAS2_HUMANCAV3_HUMANHPRD7797570 details
GNAS2_HUMANCHIP_HUMANBioGRID30443176 details