Entity Details

Primary name 2ABB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ00005
EntryName2ABB_HUMAN
FullNameSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
TaxID9606
Evidenceevidence at protein level
Length443
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-04-07

Ontological Relatives

GenesPPP2R2B

GO terms

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GOName
GO:0000159 protein phosphatase type 2A complex
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006915 apoptotic process
GO:0019888 protein phosphatase regulator activity
GO:0070262 peptidyl-serine dephosphorylation

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Mitochondrion
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR000009 Protein phosphatase 2A regulatory subunit PR55FamilyFamily
IPR001680 WD40 repeatRepeatRepeat
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR018067 Protein phosphatase 2A regulatory subunit PR55, conserved siteSiteConserved site
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
604326 OMIMSpinocerebellar ataxia 12 (SCA12)Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA12 is an autosomal dominant cerebellar ataxia (ADCA). The disease is caused by variants affecting the gene represented in this entry.