Entity Details

Primary name CDK6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ00534
EntryNameCDK6_HUMAN
FullNameCyclin-dependent kinase 6
TaxID9606
Evidenceevidence at protein level
Length326
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesCDK6

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0001726 ruffle
GO:0001954 positive regulation of cell-matrix adhesion
GO:0003323 type B pancreatic cell development
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0008285 negative regulation of cell population proliferation
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0009615 response to virus
GO:0010468 regulation of gene expression
GO:0014002 astrocyte development
GO:0016592 mediator complex
GO:0021542 dentate gyrus development
GO:0021670 lateral ventricle development
GO:0030332 cyclin binding
GO:0042063 gliogenesis
GO:0043697 cell dedifferentiation
GO:0045596 negative regulation of cell differentiation
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045646 regulation of erythrocyte differentiation
GO:0045656 negative regulation of monocyte differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045786 negative regulation of cell cycle
GO:0048146 positive regulation of fibroblast proliferation
GO:0048699 generation of neurons
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051301 cell division
GO:0051726 regulation of cell cycle
GO:0098770 FBXO family protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000145 regulation of cell motility
GO:2000773 negative regulation of cellular senescence

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR028788 Cyclin-dependent kinase 6FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB03496 AlvocidibDrugbanksmall molecule
DB07379 (2S)-2-({6-[(3-Amino-5-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methyl-1-butanolDrugbanksmall molecule
DB07795 FisetinDrugbanksmall molecule
DB09073 PalbociclibDrugbanksmall molecule
DB11730 RibociclibDrugbanksmall molecule
DB12001 AbemaciclibDrugbanksmall molecule

Interactions

152 interactions

InteractorPartnerSourcesPublicationsLink
CDK6_HUMANCDC37_HUMANBioGRID, HPRD, IntAct24292678 25036637 8666233 9150368 details
CDK6_HUMANMCM2_HUMANBioGRID, HPRD, IntAct15232106 details
CDK6_HUMANCDN2A_HUMANBioGRID, IntAct10022865 10491434 11556834 11739795 15232106 17881001 17909018 17955473 23602568 24855949 26186194 28205554 28514442 8805225 9380698 9751050 details
CDK6_HUMANMCM10_HUMANBioGRID, HPRD, IntAct15232106 details
CDK6_HUMANCCND3_HUMANBioGRID, DIP, HPRD, IntAct, MINT11360184 15232106 16782892 17517622 21516116 23602568 25416956 26186194 26264872 27107012 28514442 29997244 30217970 31515488 32296183 32814053 33854235 8114739 9716181 details
CDK6_HUMANCCND1_HUMANBioGRID, DIP, HPRD, IntAct10022865 10580009 11160398 11360184 11739795 15232106 17420273 17517622 19075005 21654808 24855949 24953629 33854235 9178893 details
CDK6_HUMANCDN1A_HUMANBioGRID, HPRD, IntAct10022865 15232106 20102411 28514442 details
CDK6_HUMANATX1_HUMANBioGRID, HPRD, IntAct16713569 details
CDK6_HUMANCDN2D_HUMANBioGRID, HPRD, IntAct10022865 23602568 25416956 26186194 27107012 28514442 31515488 32296183 9751050 9751051 details
CDK6_HUMANCDN2C_HUMANBioGRID, HPRD, IntAct, UniProt10022865 11124804 12370184 17353931 18394558 23602568 25416956 25502805 25910212 26186194 27107012 28205554 28514442 31515488 32296183 8001816 8840966 details
CDK6_HUMANPML_HUMANBioGRID, IntAct21840486 details
CDK6_HUMANMYC_HUMANBioGRID, IntAct22094256 28205554 details
CDK6_HUMANMZF1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANNUMA1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANZN335_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANRBL2_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANZN101_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANFOXM1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANSRBS1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANCDC6_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANBC11A_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANANR12_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANRB_HUMANBioGRID, HPRD, IntAct10486249 10491434 14627988 16878158 16985050 22094256 24953629 7629134 9199321 9885575 details
CDK6_HUMANSLBP_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANSENP3_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANRBL1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANSOX5_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANZN823_HUMANIntAct22094256 details
CDK6_HUMANTRA2B_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANSRSF2_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANSRS12_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANZEB1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANSRSF7_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANISL1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANTRAK1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANN4BP1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANEZH2_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANNIPBL_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANCOE4_HUMANBioGRID, IntAct22094256 details
CDK6_HUMAN4ET_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANSRSF1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANMEF2D_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANNFAC3_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANMS3L1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANABI1_HUMANIntAct22094256 details
CDK6_HUMANTFDP1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANDEDD2_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANELK1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANRBM23_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANPOGZ_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANSNIP1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANATF6B_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANKLF10_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANCLASR_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANELOA2_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANSYNP2_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANLPIN1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANSRS11_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANZMYM3_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANAF9_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANFOXO3_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANPRAX_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANHSF1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANZO2_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANSIR1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANTPX2_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANPRGC1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANCBY1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANVGLL4_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANZSCA1_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANDDIT3_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANSOX10_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANSSBP2_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANPPHLN_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANCASC3_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANZN174_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANTRA2A_HUMANBioGRID, IntAct22094256 details
CDK6_HUMANUHRF2_HUMANBioGRID, UniProt21952639 details
CDK6_HUMANCDK4_HUMANBioGRID, IntAct23455922 28205554 details
CDK6_HUMANCCND2_HUMANBioGRID, IntAct10022865 11360184 23602568 28205554 30217970 9178893 details
CDK6_HUMANCDN2B_HUMANBioGRID, IntAct10022865 23602568 25416956 26186194 26578655 28205554 28514442 32296183 details
CDK6_HUMANTRI15_HUMANBioGRID, IntAct32296183 details
CDK6_HUMANCCNI_HUMANBioGRID, IntAct32296183 details
CDK6_HUMANOTP_HUMANBioGRID, IntAct32296183 details
CDK6_HUMANCCNH_HUMANBioGRID, IntAct32296183 details
CDK6_HUMANABEC1_HUMANBioGRID, IntAct32296183 details
CDK6_HUMANARF_HUMANBioGRID, HPRD10022865 10491434 11556834 11739795 15232106 17881001 17909018 17955473 23602568 26186194 28205554 28514442 8805225 9380698 9751050 details
CDK6_HUMANPP2AA_HUMANBioGRID10934208 details
CDK6_HUMANPPM1B_HUMANBioGRID, HPRD10934208 details
CDK6_HUMANCCNE1_HUMANBioGRID28205554 9716181 details
CDK6_HUMANKI26B_HUMANBioGRID22768111 details
CDK6_HUMANCDK7_HUMANBioGRID7629134 details
CDK6_HUMANH11_HUMANBioGRID16878158 9885575 details
CDK6_HUMANABI2_HUMANBioGRID22094256 details
CDK6_HUMANTTP_HUMANBioGRID22094256 details
CDK6_HUMANCDK6_HUMANBioGRID, HPRD11124804 23602568 28205554 details
CDK6_HUMANDAB1_HUMANBioGRID15110774 25416956 details
CDK6_HUMANPSA3_HUMANBioGRID25416956 details
CDK6_HUMANU17L2_HUMANBioGRID28067227 details
CDK6_HUMANRBPMS_HUMANBioGRID27107012 details
CDK6_HUMANSUMO1_HUMANBioGRID24953629 details
CDK6_HUMANARNT_HUMANBioGRID28205554 details
CDK6_HUMANBECN1_HUMANBioGRID28205554 details
CDK6_HUMANAKT1_HUMANBioGRID28205554 details
CDK6_HUMANCD44_HUMANBioGRID28205554 details
CDK6_HUMANEPHA2_HUMANBioGRID28205554 details
CDK6_HUMANFGFR4_HUMANBioGRID28205554 details
CDK6_HUMANLATS2_HUMANBioGRID28205554 details
CDK6_HUMANSTK11_HUMANBioGRID28205554 details
CDK6_HUMANFZR1_HUMANBioGRID28205554 details
CDK6_HUMANGLIS2_HUMANBioGRID28205554 details
CDK6_HUMANMP2K3_HUMANBioGRID28205554 details
CDK6_HUMANMP2K5_HUMANBioGRID28205554 details
CDK6_HUMANMERL_HUMANBioGRID28205554 details
CDK6_HUMANRAF1_HUMANBioGRID28205554 details
CDK6_HUMANRASF1_HUMANBioGRID28205554 details
CDK6_HUMANARAF_HUMANBioGRID28205554 details
CDK6_HUMANCBLC_HUMANBioGRID28205554 details
CDK6_HUMANKEAP1_HUMANBioGRID28205554 details
CDK6_HUMANM3K5_HUMANBioGRID28205554 details
CDK6_HUMANTEAD2_HUMANBioGRID28205554 details
CDK6_HUMANTERT_HUMANBioGRID28205554 details
CDK6_HUMANTSC1_HUMANBioGRID28205554 details
CDK6_HUMANERBB2_HUMANBioGRID28205554 details
CDK6_HUMANGLIS1_HUMANBioGRID28205554 details
CDK6_HUMANGRM1_HUMANBioGRID28205554 details
CDK6_HUMANHGF_HUMANBioGRID28205554 details
CDK6_HUMANHIF1A_HUMANBioGRID28205554 details
CDK6_HUMANKAT2A_HUMANBioGRID28205554 details
CDK6_HUMANERD22_HUMANBioGRID28205554 details
CDK6_HUMANMK14_HUMANBioGRID28205554 details
CDK6_HUMANMET_HUMANBioGRID28205554 details
CDK6_HUMANPGFRA_HUMANBioGRID28205554 details
CDK6_HUMANTNR1A_HUMANBioGRID28205554 details
CDK6_HUMANP53_HUMANBioGRID28205554 details
CDK6_HUMANUBP51_HUMANBioGRID32296027 details
CDK6_HUMANRUNX1_HUMANBioGRID, HPRD, IntAct, MINT17431401 25241761 details
CDK6_HUMANHS90B_HUMANIntAct22939624 details
CDK6_HUMANCTNB1_HUMANBioGRID, HPRD, IntAct17208333 25241761 details
CDK6_HUMANANDR_HUMANBioGRID, HPRD, IntAct15790678 25241761 details
CDK6_HUMANCDK2_HUMANBioGRID, IntAct10934208 25241761 details
CDK6_HUMANCDN1B_HUMANBioGRID, IntAct10022865 11360184 16782892 18615582 21439954 25241761 28514442 details
CDK6_HUMANFBX7_HUMANBioGRID18495667 details
CDK6_HUMANCD5R1_HUMANBioGRID22654103 details
CDK6_HUMANCCNA2_HUMANBioGRID9716181 details
CDK6_HUMANUCHL1_HUMANBioGRID23543736 details
CDK6_HUMANEGLN2_HUMANBioGRID26644182 details
CDK6_HUMANUBC9_HUMANBioGRID24953629 details
CDK6_HUMANUBE2N_HUMANBioGRID31373842 details
CDK6_HUMANPCNA_HUMANHPRD9667749 details
CDK6_HUMANCNOT7_HUMANHPRD10602502 details
CDK6_HUMANTGFR1_HUMANHPRD15761153 details