Entity Details

Primary name EF1A2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ05639
EntryNameEF1A2_HUMAN
FullNameElongation factor 1-alpha 2
TaxID9606
Evidenceevidence at protein level
Length463
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesEEF1A2

GO terms

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GOName
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005853 eukaryotic translation elongation factor 1 complex
GO:0006412 translation
GO:0006414 translational elongation
GO:0008135 translation factor activity, RNA binding
GO:0010035 response to inorganic substance
GO:0019901 protein kinase binding
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0045202 synapse
GO:0051602 response to electrical stimulus
GO:0090218 positive regulation of lipid kinase activity
GO:0098574 cytoplasmic side of lysosomal membrane
GO:1904714 regulation of chaperone-mediated autophagy

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000795 Translational (tr)-type GTP-binding domainDomainDomain
IPR004160 Translation elongation factor EFTu/EF1A, C-terminalDomainDomain
IPR004161 Translation elongation factor EFTu-like, domain 2DomainDomain
IPR004539 Translation elongation factor EF1A, eukaryotic/archaealFamilyFamily
IPR009000 Translation protein, beta-barrel domain superfamilyFamilyHomologous superfamily
IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminalFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR031157 Tr-type G domain, conserved siteSiteConserved site

Diseases

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Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
EF1A2_HUMANMK06_HUMANBioGRID, MINT21900206 details
EF1A2_HUMANLRRK2_HUMANIntAct19559761 31046837 details
EF1A2_HUMANSTK11_HUMANBioGRID, MINT25640309 details
EF1A2_HUMANABTB1_HUMANBioGRID, IntAct25416956 28514442 31515488 32296183 details
EF1A2_HUMANTTL12_HUMANBioGRID, IntAct22939629 28514442 32296183 details
EF1A2_HUMANTCTP_HUMANBioGRID, IntAct25635048 28514442 details
EF1A2_HUMANHD_HUMANIntAct32814053 details
EF1A2_HUMANERG_HUMANBioGRID24591637 details
EF1A2_HUMANSUMO2_HUMANBioGRID32786267 details
EF1A2_HUMANUBE3A_HUMANBioGRID31329371 details
EF1A2_HUMANM3K8_HUMANIntAct14743216 details
EF1A2_HUMANIKKA_HUMANIntAct14743216 details
EF1A2_HUMANNEMO_HUMANIntAct14743216 details
EF1A2_HUMANM3K1_HUMANIntAct14743216 details
EF1A2_HUMANM3K3_HUMANIntAct14743216 details
EF1A2_HUMANNFKB2_HUMANIntAct14743216 details
EF1A2_HUMANTF65_HUMANIntAct14743216 details
EF1A2_HUMANRIPK3_HUMANIntAct14743216 details
EF1A2_HUMANTAB2_HUMANIntAct14743216 details
EF1A2_HUMANTNR1B_HUMANIntAct14743216 details
EF1A2_HUMANTRADD_HUMANIntAct14743216 details
EF1A2_HUMANTRAF2_HUMANIntAct14743216 details
EF1A2_HUMANTRAF6_HUMANIntAct14743216 details
EF1A2_HUMANMGMT_HUMANBioGRID16226712 details
EF1A2_HUMANSRRM2_HUMANBioGRID16159877 details
EF1A2_HUMANPTEN_HUMANBioGRID15717329 details
EF1A2_HUMANNFX1_HUMANBioGRID17267499 details
EF1A2_HUMANUBXN6_HUMANBioGRID22337587 details
EF1A2_HUMANSEM1_HUMANBioGRID24515614 details
EF1A2_HUMANSEML_HUMANBioGRID24515614 details
EF1A2_HUMANDPF3_HUMANBioGRID26582913 details
EF1A2_HUMANCDK9_HUMANBioGRID26209609 details
EF1A2_HUMANPSA3_HUMANBioGRID30009671 details
EF1A2_HUMANACM4_HUMANHPRD12048193 details
EF1A2_HUMANTSPY1_HUMANHPRD18649364 details