Entity Details

Primary name FOLC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ05932
EntryNameFOLC_HUMAN
FullNameFolylpolyglutamate synthase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length587
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesFPGS

GO terms

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GOName
GO:0001889 liver development
GO:0004326 tetrahydrofolylpolyglutamate synthase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006139 nucleobase-containing compound metabolic process
GO:0006536 glutamate metabolic process
GO:0006730 one-carbon metabolic process
GO:0006760 folic acid-containing compound metabolic process
GO:0007420 brain development
GO:0008283 cell population proliferation
GO:0009396 folic acid-containing compound biosynthetic process
GO:0031100 animal organ regeneration
GO:0046655 folic acid metabolic process
GO:0046872 metal ion binding
GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion inner membrane
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR001645 Folylpolyglutamate synthetaseFamilyFamily
IPR018109 Folylpolyglutamate synthetase, conserved siteSiteConserved site
IPR023600 Folylpolyglutamate synthase, eukaryotaFamilyFamily
IPR036565 Mur-like, catalytic domain superfamilyFamilyHomologous superfamily
IPR036615 Mur ligase, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00142 Glutamic acidDrugbanksmall molecule
DB00293 RaltitrexedDrugbanksmall molecule
DB00563 MethotrexateDrugbanksmall molecule
DB06813 PralatrexateDrugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink