Entity Details

Primary name AOXA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ06278
EntryNameAOXA_HUMAN
FullNameAldehyde oxidase
TaxID9606
Evidenceevidence at protein level
Length1338
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesAOX1

GO terms

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GOName
GO:0004031 aldehyde oxidase activity
GO:0005506 iron ion binding
GO:0005829 cytosol
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0017144 drug metabolic process
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042816 vitamin B6 metabolic process
GO:0043546 molybdopterin cofactor binding
GO:0050660 flavin adenine dinucleotide binding
GO:0051287 NAD binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0070062 extracellular exosome
GO:0071949 FAD binding
GO:0102797 geranial:oxygen oxidoreductase activity
GO:0102798 heptaldehyde:oxygen oxidoreductase activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerheadDomainDomain
IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domainDomainDomain
IPR002346 Molybdopterin dehydrogenase, FAD-bindingDomainDomain
IPR002888 [2Fe-2S]-bindingDomainDomain
IPR005107 CO dehydrogenase flavoprotein, C-terminalDomainDomain
IPR006058 2Fe-2S ferredoxin, iron-sulphur binding siteSiteBinding site
IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin bindingDomainDomain
IPR014313 Aldehyde oxidaseFamilyFamily
IPR016166 FAD-binding domain, PCMH-typeDomainDomain
IPR016208 Aldehyde oxidase/xanthine dehydrogenaseFamilyFamily
IPR022407 Oxidoreductase, molybdopterin binding siteSiteBinding site
IPR036010 2Fe-2S ferredoxin-like superfamilyFamilyHomologous superfamily
IPR036318 FAD-binding, type PCMH-like superfamilyFamilyHomologous superfamily
IPR036683 CO dehydrogenase flavoprotein, C-terminal domain superfamilyFamilyHomologous superfamily
IPR036856 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamilyFamilyHomologous superfamily
IPR036884 [2Fe-2S]-binding domain superfamilyFamilyHomologous superfamily
IPR037165 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00170 MenadioneDrugbanksmall molecule
DB00246 ZiprasidoneDrugbanksmall molecule
DB00339 PyrazinamideDrugbanksmall molecule
DB00426 FamciclovirDrugbanksmall molecule
DB00437 AllopurinolDrugbanksmall molecule
DB00481 RaloxifeneDrugbanksmall molecule
DB00484 BrimonidineDrugbanksmall molecule
DB00513 Aminocaproic acidDrugbanksmall molecule
DB00563 MethotrexateDrugbanksmall molecule
DB00909 ZonisamideDrugbanksmall molecule
DB00924 CyclobenzaprineDrugbanksmall molecule
DB00962 ZaleplonDrugbanksmall molecule
DB01033 MercaptopurineDrugbanksmall molecule
DB03516 EniluracilDrugbanksmall molecule
DB04827 UrethaneSwissprotsmall molecule
DB08840 N-methylnicotinamideSwissprotsmall molecule
DB09054 IdelalisibDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB11791 CapmatinibDrugbanksmall molecule
DB12466 FavipiravirDrugbanksmall molecule

Interactions

7 interactions