Entity Details

Primary name SUH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ06330
EntryNameSUH_HUMAN
FullNameRecombining binding protein suppressor of hairless
TaxID9606
Evidenceevidence at protein level
Length500
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesRBPJ

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001525 angiogenesis
GO:0001756 somitogenesis
GO:0001837 epithelial to mesenchymal transition
GO:0001974 blood vessel remodeling
GO:0002193 MAML1-RBP-Jkappa- ICN1 complex
GO:0002437 inflammatory response to antigenic stimulus
GO:0003139 secondary heart field specification
GO:0003151 outflow tract morphogenesis
GO:0003160 endocardium morphogenesis
GO:0003176 aortic valve development
GO:0003177 pulmonary valve development
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003214 cardiac left ventricle morphogenesis
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006959 humoral immune response
GO:0007219 Notch signaling pathway
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0009912 auditory receptor cell fate commitment
GO:0009957 epidermal cell fate specification
GO:0010628 positive regulation of gene expression
GO:0017053 transcription repressor complex
GO:0021983 pituitary gland development
GO:0030183 B cell differentiation
GO:0030216 keratinocyte differentiation
GO:0030279 negative regulation of ossification
GO:0030513 positive regulation of BMP signaling pathway
GO:0035019 somatic stem cell population maintenance
GO:0035912 dorsal aorta morphogenesis
GO:0036302 atrioventricular canal development
GO:0042742 defense response to bacterium
GO:0043011 myeloid dendritic cell differentiation
GO:0043565 sequence-specific DNA binding
GO:0045596 negative regulation of cell differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0047485 protein N-terminus binding
GO:0048505 regulation of timing of cell differentiation
GO:0048733 sebaceous gland development
GO:0048820 hair follicle maturation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060412 ventricular septum morphogenesis
GO:0060486 club cell differentiation
GO:0060716 labyrinthine layer blood vessel development
GO:0060844 arterial endothelial cell fate commitment
GO:0061314 Notch signaling involved in heart development
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0072554 blood vessel lumenization
GO:0097101 blood vessel endothelial cell fate specification
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1901186 positive regulation of ERBB signaling pathway
GO:1901189 positive regulation of ephrin receptor signaling pathway
GO:1901297 positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR015350 Beta-trefoil DNA-binding domainDomainDomain
IPR015351 RBP-J/Cbf11/Cbf12, DNA bindingDomainDomain
IPR036358 Beta-trefoil domain superfamilyFamilyHomologous superfamily
IPR037095 RBP-J/Cbf11, DNA binding domain superfamilyFamilyHomologous superfamily
IPR038007 RBP-Jkappa, IPT domainDomainDomain
IPR040159 Suppressor of hairless-likeFamilyFamily

Diseases

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Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
SUH_HUMANCIR1_HUMANBioGRID, HPRD, IntAct9874765 details
SUH_HUMANSNW1_HUMANBioGRID, HPRD, IntAct10644367 10713164 details
SUH_HUMANNCOR2_HUMANBioGRID, HPRD, IntAct, MINT10713164 11404076 11509665 21475249 details
SUH_HUMANNOTC1_HUMANBioGRID, DIP, HPRD, IntAct, MINT10637481 10713164 11390662 11997524 12644465 16530044 17284587 17526737 17573339 17636029 19321451 19800882 19907488 21475249 21820430 22100894 22143792 22325781 23022380 23103515 25609649 26033182 26186194 26496610 28514442 30967258 30975888 8749394 9111040 details
SUH_HUMANRITA1_HUMANBioGRID, MINT21102556 25609649 details
SUH_HUMANMINT_HUMANBioGRID, HPRD, IntAct, MINT12374742 18332109 21102556 25609649 26186194 28514442 details
SUH_HUMANATX1L_HUMANMINT21475249 details
SUH_HUMANATX1_HUMANMINT21475249 details
SUH_HUMANMED27_HUMANBioGRID, IntAct21988832 details
SUH_HUMANGA45A_HUMANBioGRID, MINT21900206 details
SUH_HUMANGSK3B_HUMANBioGRID, MINT21900206 details
SUH_HUMANKS6A6_HUMANBioGRID, MINT21900206 details
SUH_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
SUH_HUMANNOTC2_HUMANBioGRID, HPRD, IntAct, MINT25609649 26186194 26496610 28514442 9032325 details
SUH_HUMANNOTC3_HUMANBioGRID, HPRD, IntAct, MINT11404076 25356737 25609649 26186194 28514442 details
SUH_HUMANP53_HUMANBioGRID, DIP26302407 details
SUH_HUMANSIN3A_HUMANBioGRID10644367 details
SUH_HUMANSND1_HUMANBioGRID, HPRD10644367 7651391 9874765 details
SUH_HUMANKAT2B_HUMANBioGRID, HPRD10747963 details
SUH_HUMANKAT2A_HUMANBioGRID10747963 details
SUH_HUMANKDM5A_HUMANBioGRID20231316 details
SUH_HUMANA4_HUMANBioGRID21832049 details
SUH_HUMANPTF1A_HUMANBioGRID25355311 details
SUH_HUMANSPOP_HUMANBioGRID28805822 details
SUH_HUMANCCNF_HUMANBioGRID30254149 details
SUH_HUMANSUFU_HUMANHPRD14611647 details
SUH_HUMANMAML1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11997524 16530044 17284587 19907488 20972443 21475249 22325781 23022380 25609649 26186194 26496610 28514442 details
SUH_HUMANLMBL2_HUMANMINT25609649 details
SUH_HUMANMECP2_HUMANBioGRID, MINT16763620 25609649 details
SUH_HUMANFHL1_HUMANBioGRID, HPRD, MINT14999091 15710417 24952875 25609649 details
SUH_HUMANBEND6_HUMANUniProt23571214 details
SUH_HUMANRUNX3_HUMANBioGRID19800882 details
SUH_HUMANMTG8_HUMANBioGRID18332109 details
SUH_HUMANKAT5_HUMANBioGRID17636029 details
SUH_HUMANBCL6B_HUMANBioGRID22279058 details
SUH_HUMANKCC4_HUMANBioGRID23103515 details
SUH_HUMANMAML3_HUMANBioGRID12370315 details
SUH_HUMANMAML2_HUMANBioGRID12370315 details
SUH_HUMANRND3_HUMANBioGRID26108681 details
SUH_HUMANZMIZ1_HUMANBioGRID26522984 details
SUH_HUMANFANCG_HUMANBioGRID19321451 details
SUH_HUMANFANCA_HUMANBioGRID19321451 details
SUH_HUMANTRBP2_HUMANBioGRID28174252 details
SUH_HUMANPRKRA_HUMANBioGRID30967258 details
SUH_HUMANNOTC4_HUMANHPRD11518718 details
SUH_HUMANNCOR1_HUMANHPRD9694793 details
SUH_HUMANHDAC1_HUMANHPRD9694793 details
SUH_HUMANHMGB1_HUMANHPRD11748221 details