Entity Details

Primary name SPRY2
Entity type gene
Source Source Link

Details

PrimaryID10253
RefseqGeneNG_050650
SymbolSPRY2
Namesprouty RTK signaling antagonist 2
Chromosome13
Location13q31.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-06-07
ModificationDate2021-06-14

Ontological Relatives

UniProt IDsSPY2_HUMAN

GO terms

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GOName
GO:0000132 establishment of mitotic spindle orientation
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0007605 sensory perception of sound
GO:0008285 negative regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0015629 actin cytoskeleton
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0016525 negative regulation of angiogenesis
GO:0019901 protein kinase binding
GO:0030291 protein serine/threonine kinase inhibitor activity
GO:0030335 positive regulation of cell migration
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031345 negative regulation of cell projection organization
GO:0031397 negative regulation of protein ubiquitination
GO:0032587 ruffle membrane
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034260 negative regulation of GTPase activity
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042472 inner ear morphogenesis
GO:0043066 negative regulation of apoptotic process
GO:0043407 negative regulation of MAP kinase activity
GO:0043539 protein serine/threonine kinase activator activity
GO:0045165 cell fate commitment
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048513 animal organ development
GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway
GO:0051897 positive regulation of protein kinase B signaling
GO:0060437 lung growth
GO:0060449 bud elongation involved in lung branching
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
GO:1902747 negative regulation of lens fiber cell differentiation
GO:1990752 microtubule end
GO:1990830 cellular response to leukemia inhibitory factor

Diseases

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Interactions

135 interactions

InteractorPartnerSourcesPublicationsLink
SPRY2TRIM51BioGRID, HPRD, IntAct16189514 details
SPRY2GPRIN2BioGRID, HPRD, IntAct16189514 details
SPRY2TRAF2BioGRID, HPRD, IntAct16189514 details
SPRY2ADAMTSL4BioGRID, HPRD, IntAct16189514 details
SPRY2PLSCR1BioGRID, HPRD, IntAct16189514 details
SPRY2KRTAP4-12BioGRID, HPRD, IntAct16189514 25416956 details
SPRY2GRB2BioGRID, HPRD, MINT10940627 12402043 15004239 16893902 17255109 17974561 32296183 details
SPRY2CBLBioGRID, HPRD, MINT11053437 11983899 12234920 12593795 12593796 12815057 15004239 15962011 16246327 16479008 16893902 17255109 17974561 18273061 20124286 20461437 20622121 20877636 21596750 details
SPRY2SH3KBP1BioGRID, MINT15962011 25416956 32296183 details
SPRY2OTX1BioGRID, IntAct, MINT21516116 25416956 details
SPRY2UBASH3ABioGRID, IntAct, MINT21516116 25416956 32296183 details
SPRY2RTF2BioGRID, MINT21900206 details
SPRY2FAM219ABioGRID, MINT21900206 details
SPRY2CRIP2BioGRID, MINT21900206 details
SPRY2CRMP1BioGRID, MINT21900206 details
SPRY2CSTBBioGRID, MINT21900206 details
SPRY2CTSBBioGRID, MINT21900206 details
SPRY2DNM2BioGRID, MINT21900206 details
SPRY2FBN1BioGRID, MINT21900206 details
SPRY2NR1H2BioGRID, MINT21900206 details
SPRY2NUBP1BioGRID, MINT21900206 details
SPRY2SDHBBioGRID, MINT21900206 details
SPRY2SEMA5BBioGRID, MINT21900206 details
SPRY2UBR1BioGRID, MINT21900206 details
SPRY2ZBTB16BioGRID, MINT21900206 details
SPRY2ZNF266BioGRID, MINT21900206 details
SPRY2KDM1ABioGRID, MINT23455924 details
SPRY2TNS2BioGRID, IntAct25814554 details
SPRY2FRS3BioGRID, IntAct25416956 details
SPRY2MEOX2BioGRID, IntAct25416956 details
SPRY2GRAP2BioGRID, IntAct25416956 32296183 details
SPRY2MDFIBioGRID, IntAct25416956 details
SPRY2SPRY1BioGRID, IntAct15004239 25416956 details
SPRY2NCK2BioGRID, IntAct25416956 details
SPRY2PRKAB2BioGRID, IntAct24722188 25416956 32296183 details
SPRY2MAPKBP1BioGRID, IntAct25416956 details
SPRY2EIF4E2BioGRID, IntAct25416956 details
SPRY2STK16BioGRID, IntAct25416956 details
SPRY2GP9BioGRID, IntAct25416956 details
SPRY2KRTAP5-9BioGRID, IntAct25416956 details
SPRY2AQP1BioGRID, IntAct25416956 details
SPRY2KRTAP10-8BioGRID, IntAct25416956 details
SPRY2KRTAP10-9BioGRID, IntAct25416956 details
SPRY2KRTAP10-11BioGRID, IntAct25416956 details
SPRY2CREB5BioGRID, IntAct25416956 details
SPRY2RUNX1T1BioGRID, IntAct25416956 32296183 details
SPRY2PTGER3BioGRID, IntAct25416956 details
SPRY2LASP1BioGRID, IntAct25416956 details
SPRY2LONRF1BioGRID, IntAct25416956 details
SPRY2LCE3CBioGRID, IntAct25416956 details
SPRY2LCE3EBioGRID, IntAct25416956 details
SPRY2LCE1BBioGRID, IntAct25416956 29892012 31515488 details
SPRY2LCE4ABioGRID, IntAct25416956 details
SPRY2LCE2DBioGRID, IntAct25416956 details
SPRY2KRTAP5-6BioGRID, IntAct25416956 details
SPRY2ZDHHC17BioGRID, IntAct24705354 25416956 26186194 28514442 details
SPRY2CATSPER1BioGRID, IntAct25416956 32296183 details
SPRY2ZNF417BioGRID, IntAct25416956 details
SPRY2UBASH3BBioGRID, IntAct25416956 details
SPRY2ATRIPBioGRID, IntAct25416956 details
SPRY2HEXIM2BioGRID, IntAct25416956 details
SPRY2ZNF587BioGRID, IntAct25416956 details
SPRY2KRTAP9-4BioGRID, IntAct25416956 details
SPRY2KRTAP9-2BioGRID, IntAct25416956 details
SPRY2KRTAP4-11BioGRID, IntAct25416956 details
SPRY2HSD3B7BioGRID, IntAct21516116 25416956 details
SPRY2CHRDBioGRID, IntAct25416956 details
SPRY2SHFLBioGRID, IntAct25416956 details
SPRY2FAIMBioGRID, IntAct25416956 details
SPRY2MID2BioGRID, IntAct25416956 details
SPRY2PACSIN3BioGRID, IntAct25416956 details
SPRY2GNEBioGRID, IntAct25416956 details
SPRY2USP20BioGRID, IntAct25416956 details
SPRY2TCAF1BioGRID, IntAct25416956 details
SPRY2SPRY2BioGRID, IntAct25416956 details
SPRY2KIF1ABioGRID, IntAct24722188 details
SPRY2CHRNGBioGRID, IntAct25910212 details
SPRY2GRNBioGRID, IntAct25910212 details
SPRY2SIAH2BioGRID16888801 details
SPRY2NEDD4BioGRID19864419 details
SPRY2ITSN1BioGRID22558309 details
SPRY2VPS25BioGRID21543492 details
SPRY2VPS36BioGRID21543492 details
SPRY2MKNK1BioGRID16479008 details
SPRY2DGCR6BioGRID24722188 details
SPRY2MLLT6BioGRID25416956 details
SPRY2TXNDC5BioGRID25416956 details
SPRY2KRTAP10-1BioGRID25416956 details
SPRY2KRTAP10-3BioGRID25416956 details
SPRY2TMEM14BBioGRID21516116 details
SPRY2BRAFBioGRID19690147 details
SPRY2PRKCDBioGRID19458088 details
SPRY2PRKD1BioGRID19458088 details
SPRY2FBXO7BioGRID27503909 details
SPRY2HNRNPLLBioGRID26871637 details
SPRY2HOXA1BioGRID32296183 details
SPRY2BAG3BioGRID32296183 details
SPRY2MB21D2BioGRID32296183 details
SPRY2LCE1ABioGRID32296183 details
SPRY2LCE1CBioGRID32296183 details
SPRY2LCE1FBioGRID32296183 details
SPRY2FXR1MINT21653829 details
SPRY2FXR2MINT21653829 details
SPRY2NUFIP2MINT21653829 details
SPRY2RAF1BioGRID, HPRD12717443 details
SPRY2TESK1BioGRID17974561 details
SPRY2PPP2CABioGRID17255109 17974561 details
SPRY2EGLN2BioGRID22006925 details
SPRY2EGLN1BioGRID22006925 details
SPRY2EGLN3BioGRID22006925 details
SPRY2VHLBioGRID22006925 details
SPRY2HRASBioGRID18048363 details
SPRY2PPP2R1ABioGRID17255109 details
SPRY2HGSBioGRID17320394 details
SPRY2SPRY4BioGRID15004239 details
SPRY2FRS2BioGRID15004239 details
SPRY2HIF1ABioGRID27281823 details
SPRY2PTPN11HPRD15031289 details
SPRY2CBLCHPRD12234920 details
SPRY2CBLBHPRD11053437 details
SPRY2TESBioGRID, IntAct28514442 details
SPRY2S100A13BioGRID, IntAct28514442 details
SPRY2PLS1BioGRID, IntAct26186194 28514442 details
SPRY2UBE2D2BioGRID, IntAct26186194 28514442 details
SPRY2CTHBioGRID, IntAct28514442 details
SPRY2SNX3BioGRID, IntAct26186194 28514442 details
SPRY2CTNNA3BioGRID23718855 details
SPRY2VANGL1BioGRID26186194 details
SPRY2UBE2E3BioGRID26186194 details
SPRY2VANGL2BioGRID26186194 details
SPRY2CAB39BioGRID26186194 details
SPRY2RNF123BioGRID29676528 details
SPRY2KRASBioGRID34079125 details
SPRY2ELAVL1BioGRID19322201 details
SPRY2ZFP36BioGRID21784977 details