Entity Details

Primary name SEPR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12884
EntryNameSEPR_HUMAN
FullNameProlyl endopeptidase FAP
TaxID9606
Evidenceevidence at protein level
Length760
SequenceStatuscomplete
DateCreated2002-03-05
DateModified2021-06-02

Ontological Relatives

GenesFAP

GO terms

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GOName
GO:0001525 angiogenesis
GO:0002020 protease binding
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005178 integrin binding
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006508 proteolysis
GO:0007155 cell adhesion
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0009986 cell surface
GO:0010710 regulation of collagen catabolic process
GO:0010716 negative regulation of extracellular matrix disassembly
GO:0016021 integral component of membrane
GO:0030027 lamellipodium
GO:0031258 lamellipodium membrane
GO:0032587 ruffle membrane
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043542 endothelial cell migration
GO:0045177 apical part of cell
GO:0045178 basal part of cell
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0051917 regulation of fibrinolysis
GO:0060244 negative regulation of cell proliferation involved in contact inhibition
GO:0097325 melanocyte proliferation
GO:1900119 positive regulation of execution phase of apoptosis
GO:1902362 melanocyte apoptotic process
GO:1903054 negative regulation of extracellular matrix organization
GO:1905368 peptidase complex

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cell surface
Cytoplasm
Membrane
Secreted

Domains

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DomainNameCategoryType
IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domainDomainDomain
IPR002469 Dipeptidylpeptidase IV, N-terminal domainDomainDomain
IPR002471 Peptidase S9, serine active siteSiteActive site
IPR029058 Alpha/Beta hydrolase foldFamilyHomologous superfamily
IPR031245 Dipeptidyl peptidase FAPFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB06474 SibrotuzumabDrugbankbiotech