Entity Details

Primary name TREX1
Entity type gene
Source Source Link

Details

PrimaryID11277
RefseqGeneNG_009820
SymbolTREX1
Namethree prime repair exonuclease 1
Chromosome3
Location3p21.31
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-05-05
ModificationDate2021-06-19

Ontological Relatives

UniProt IDsTREX1_HUMAN

GO terms

Show/Hide Table
GOName
GO:0000287 magnesium ion binding
GO:0000738 DNA catabolic process, exonucleolytic
GO:0001568 blood vessel development
GO:0001822 kidney development
GO:0002253 activation of immune response
GO:0002281 macrophage activation involved in immune response
GO:0002320 lymphoid progenitor cell differentiation
GO:0002383 immune response in brain or nervous system
GO:0002437 inflammatory response to antigenic stimulus
GO:0002457 T cell antigen processing and presentation
GO:0002637 regulation of immunoglobulin production
GO:0003007 heart morphogenesis
GO:0003015 heart process
GO:0003228 atrial cardiac muscle tissue development
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006091 generation of precursor metabolites and energy
GO:0006110 regulation of glycolytic process
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006304 DNA modification
GO:0006310 DNA recombination
GO:0008250 oligosaccharyltransferase complex
GO:0008296 3'-5'-exodeoxyribonuclease activity
GO:0008301 DNA binding, bending
GO:0008340 determination of adult lifespan
GO:0008408 3'-5' exonuclease activity
GO:0008853 exodeoxyribonuclease III activity
GO:0019217 regulation of fatty acid metabolic process
GO:0032197 transposition, RNA-mediated
GO:0032405 MutLalpha complex binding
GO:0032407 MutSalpha complex binding
GO:0032479 regulation of type I interferon production
GO:0032508 DNA duplex unwinding
GO:0032558 adenyl deoxyribonucleotide binding
GO:0032680 regulation of tumor necrosis factor production
GO:0032993 protein-DNA complex
GO:0034614 cellular response to reactive oxygen species
GO:0035458 cellular response to interferon-beta
GO:0035781 CD86 biosynthetic process
GO:0042803 protein homodimerization activity
GO:0043277 apoptotic cell clearance
GO:0043457 regulation of cellular respiration
GO:0043596 nuclear replication fork
GO:0045184 establishment of protein localization
GO:0046872 metal ion binding
GO:0046890 regulation of lipid biosynthetic process
GO:0050699 WW domain binding
GO:0050727 regulation of inflammatory response
GO:0050790 regulation of catalytic activity
GO:0050821 protein stabilization
GO:0050863 regulation of T cell activation
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
GO:0060339 negative regulation of type I interferon-mediated signaling pathway
GO:0061635 regulation of protein complex stability
GO:0071480 cellular response to gamma radiation
GO:0072394 obsolete detection of stimulus involved in cell cycle checkpoint
GO:0072421 obsolete detection of DNA damage stimulus involved in DNA damage checkpoint
GO:0072711 cellular response to hydroxyurea
GO:0097281 immune complex formation
GO:1904161 DNA synthesis involved in UV-damage excision repair
GO:1905671 regulation of lysosome organization

Diseases

Show/Hide Table

Interactions

45 interactions

InteractorPartnerSourcesPublicationsLink
TREX1KRTAP10-7BioGRID, IntAct25416956 25910212 details
TREX1CYSRT1BioGRID, IntAct32296183 details
TREX1CD81BioGRID, IntAct32296183 details
TREX1IFNGR2BioGRID, IntAct32296183 details
TREX1TM4SF18BioGRID, IntAct32296183 details
TREX1HSD17B13BioGRID, IntAct32296183 details
TREX1CLDN22BioGRID, IntAct32296183 details
TREX1TMEM86BBioGRID, IntAct32296183 details
TREX1RNASEKBioGRID, IntAct32296183 details
TREX1FNDC9BioGRID, IntAct32296183 details
TREX1SLC10A6BioGRID, IntAct32296183 details
TREX1PEX12BioGRID, IntAct32296183 details
TREX1CRB3BioGRID, IntAct32296183 details
TREX1RELL1BioGRID, IntAct32296183 details
TREX1TMX2BioGRID, IntAct32296183 details
TREX1SLC7A14BioGRID, IntAct32296183 details
TREX1MFSD14BBioGRID, IntAct32296183 details
TREX1CYB561BioGRID, IntAct32296183 details
TREX1AQP6BioGRID, IntAct32296183 details
TREX1FFAR3BioGRID, IntAct32296183 details
TREX1TMEM207BioGRID, IntAct32296183 details
TREX1GPR42BioGRID, IntAct32296183 details
TREX1GKN1BioGRID, IntAct32296183 details
TREX1TMEM205BioGRID, IntAct32296183 details
TREX1EBPBioGRID, IntAct32296183 details
TREX1GJA5BioGRID, IntAct32296183 details
TREX1ELOVL4BioGRID, IntAct32296183 details
TREX1FAM174ABioGRID, IntAct32296183 details
TREX1PRNDBioGRID, IntAct32296183 details
TREX1TMEM45BBioGRID, IntAct32296183 details
TREX1JAGN1BioGRID, IntAct32296183 details
TREX1SEC11CBioGRID, IntAct32296183 details
TREX1JPH3IntAct32814053 details
TREX1RIBC2BioGRID16189514 details
TREX1IFT20BioGRID16189514 details
TREX1SETBioGRID16818237 details
TREX1VKORC1BioGRID21103663 details
TREX1UBQLN1BioGRID23979357 details
TREX1CHCHD2BioGRID21516116 details
TREX1SLC22A2BioGRID31318583 details
TREX1RAB23BioGRID, IntAct28514442 details
TREX1ACTA2BioGRID, IntAct28514442 details
TREX1H4C1BioGRID30804502 details
TREX1MOV10BioGRID22658674 details
TREX1NXF1BioGRID22658674 details