Entity Details

Primary name PDE3B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13370
EntryNamePDE3B_HUMAN
FullNamecGMP-inhibited 3',5'-cyclic phosphodiesterase B
TaxID9606
Evidenceevidence at protein level
Length1112
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesPDE3B

GO terms

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GOName
GO:0001525 angiogenesis
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0007162 negative regulation of cell adhesion
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016525 negative regulation of angiogenesis
GO:0032045 guanyl-nucleotide exchange factor complex
GO:0032869 cellular response to insulin stimulus
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0043422 protein kinase B binding
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0046872 metal ion binding
GO:0050995 negative regulation of lipid catabolic process

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domainDomainDomain
IPR003607 HD/PDEase domainDomainDomain
IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved siteSiteConserved site
IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule
DB01427 AmrinoneDrugbanksmall molecule
DB01640 6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-yl]amino}phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-oneDrugbanksmall molecule
DB01970 Hg9a-9, Nonanoyl-N-HydroxyethylglucamideDrugbanksmall molecule
DB07954 3-isobutyl-1-methyl-7H-xanthineDrugbanksmall molecule
DB09283 TrapidilDrugbanksmall molecule