Entity Details

Primary name FOXC1
Entity type gene
Source Source Link

Details

PrimaryID2296
RefseqGeneNG_009368
SymbolFOXC1
Nameforkhead box C1
Chromosome6
Location6p25.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-12-22
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsFOXC1_HUMAN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000792 heterochromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001525 angiogenesis
GO:0001541 ovarian follicle development
GO:0001654 eye development
GO:0001657 ureteric bud development
GO:0001701 in utero embryonic development
GO:0001756 somitogenesis
GO:0001822 kidney development
GO:0001945 lymph vessel development
GO:0001958 endochondral ossification
GO:0001974 blood vessel remodeling
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007219 Notch signaling pathway
GO:0007507 heart development
GO:0008134 transcription factor binding
GO:0008283 cell population proliferation
GO:0008301 DNA binding, bending
GO:0008354 germ cell migration
GO:0009653 anatomical structure morphogenesis
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0014031 mesenchymal cell development
GO:0014032 neural crest cell development
GO:0016477 cell migration
GO:0016525 negative regulation of angiogenesis
GO:0021549 cerebellum development
GO:0030154 cell differentiation
GO:0030199 collagen fibril organization
GO:0030203 glycosaminoglycan metabolic process
GO:0032808 lacrimal gland development
GO:0035050 embryonic heart tube development
GO:0036438 maintenance of lens transparency
GO:0038084 vascular endothelial growth factor signaling pathway
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043010 camera-type eye development
GO:0043388 positive regulation of DNA binding
GO:0043565 sequence-specific DNA binding
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046620 regulation of organ growth
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048341 paraxial mesoderm formation
GO:0048844 artery morphogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060038 cardiac muscle cell proliferation
GO:0070098 chemokine-mediated signaling pathway
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0072010 glomerular epithelium development
GO:0097746 blood vessel diameter maintenance
GO:1901491 negative regulation of lymphangiogenesis
GO:1901534 positive regulation of hematopoietic progenitor cell differentiation
GO:1902038 positive regulation of hematopoietic stem cell differentiation
GO:1902257 negative regulation of apoptotic process involved in outflow tract morphogenesis
GO:1904798 positive regulation of core promoter binding
GO:1990841 promoter-specific chromatin binding
GO:1990869 cellular response to chemokine

Diseases

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Interactions

79 interactions

InteractorPartnerSourcesPublicationsLink
FOXC1C1QBPUniProt18676636 details
FOXC1PITX2IntAct16449236 details
FOXC1FLNAUniProt15684392 details
FOXC1PBX1BioGRID, MINT, UniProt15684392 25609649 details
FOXC1TFCP2BioGRID, MINT25609649 29091762 details
FOXC1YAP1BioGRID29091762 details
FOXC1HMGB1HPRD11748221 details
FOXC1EGLN3BioGRID, IntAct26972000 details
FOXC1AIM2BioGRID, IntAct25665578 details
FOXC1PYHIN1BioGRID, IntAct25665578 details
FOXC1SALL1BioGRID, MINT25609649 details
FOXC1DLX5BioGRID, MINT25609649 details
FOXC1SATB2BioGRID, MINT25609649 details
FOXC1HOXD13BioGRID, MINT25609649 details
FOXC1MEIS1BioGRID, MINT25609649 details
FOXC1FOXC2BioGRID, MINT25609649 details
FOXC1MECP2BioGRID, MINT25609649 details
FOXC1SMARCA5BioGRID, MINT25609649 details
FOXC1UBP1BioGRID, MINT25609649 details
FOXC1PBX2BioGRID, MINT25609649 details
FOXC1TP53BioGRID, MINT25609649 details
FOXC1DDX39ABioGRID, MINT25609649 details
FOXC1RECQLBioGRID, MINT25609649 details
FOXC1VARS1BioGRID, MINT25609649 details
FOXC1LDB1BioGRID, MINT25609649 details
FOXC1HOXC13BioGRID, MINT25609649 details
FOXC1HOXB9BioGRID, MINT25609649 details
FOXC1C5orf24BioGRID, MINT25609649 details
FOXC1SMARCA1BioGRID, MINT25609649 details
FOXC1CREB1BioGRID, MINT25609649 details
FOXC1GATAD2BBioGRID, MINT25609649 details
FOXC1SATB1BioGRID, MINT25609649 details
FOXC1NFICBioGRID, MINT25609649 details
FOXC1FOXC1MINT25609649 details
FOXC1NDUFA11BioGRID, MINT25609649 details
FOXC1FOXJ2BioGRID, MINT25609649 details
FOXC1FOXS1BioGRID, MINT25609649 details
FOXC1FOXD4BioGRID, MINT25609649 details
FOXC1PPP2R1ABioGRID, IntAct26496610 details
FOXC1PPP2R2ABioGRID, IntAct26496610 28330616 details
FOXC1BCORBioGRID, IntAct27505670 details
FOXC1PPP2R2DBioGRID, IntAct28330616 28514442 details
FOXC1METTL6BioGRID, IntAct26186194 28514442 details
FOXC1HSPBP1BioGRID, IntAct28514442 details
FOXC1HSPA8BioGRID, IntAct28514442 details
FOXC1H2BC5MINT25281560 details
FOXC1H2BC8BioGRID, MINT25281560 34079125 details
FOXC1H2BC7MINT25281560 details
FOXC1H2BC6MINT25281560 details
FOXC1H2BC10MINT25281560 details
FOXC1H2BC4MINT25281560 details
FOXC1SOX2BioGRID, MINT23667531 28794006 details
FOXC1CCDC8BioGRID24711643 details
FOXC1PRMT6BioGRID26186194 details
FOXC1PPP2CBBioGRID26186194 27880917 details
FOXC1FBXW11BioGRID25515538 details
FOXC1DACH1BioGRID25609649 details
FOXC1NFIXBioGRID25609649 details
FOXC1POU2F1BioGRID25609649 details
FOXC1RC3H2BioGRID30209976 details
FOXC1H4C1BioGRID30804502 details
FOXC1PLEKHA4BioGRID31091453 details
FOXC1SP100BioGRID31753913 details
FOXC1CICBioGRID29844126 details
FOXC1CCAR2BioGRID32152128 details
FOXC1APEX1BioGRID34079125 details
FOXC1COILBioGRID34079125 details
FOXC1PARP1BioGRID34079125 details
FOXC1TERF2IPBioGRID34079125 details
FOXC1TFAP2CIntAct25303530 details
FOXC1FOSIntAct25303530 details
FOXC1FOXA1IntAct25303530 details
FOXC1JUNIntAct25303530 details
FOXC1RARGIntAct25303530 details
FOXC1ESR1IntAct25303530 details
FOXC1RARAIntAct25303530 details
FOXC1GATA3IntAct25303530 details
FOXC1ELAVL1BioGRID19322201 details
FOXC1MKRN2BioGRID32460013 details