Entity Details

Primary name NRG1
Entity type gene
Source Source Link

Details

PrimaryID3084
RefseqGeneNG_012005
SymbolNRG1
Nameneuregulin 1
Chromosome8
Location8p12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-07-13
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsNRG1_HUMAN

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003712 transcription coregulator activity
GO:0005102 signaling receptor binding
GO:0005125 cytokine activity
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0007154 cell communication
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0007399 nervous system development
GO:0008083 growth factor activity
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0014032 neural crest cell development
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0030154 cell differentiation
GO:0030296 protein tyrosine kinase activator activity
GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
GO:0030307 positive regulation of cell growth
GO:0030879 mammary gland development
GO:0030971 receptor tyrosine kinase binding
GO:0031334 positive regulation of protein-containing complex assembly
GO:0032148 activation of protein kinase B activity
GO:0035556 intracellular signal transduction
GO:0038127 ERBB signaling pathway
GO:0038128 ERBB2 signaling pathway
GO:0038129 ERBB3 signaling pathway
GO:0038130 ERBB4 signaling pathway
GO:0042060 wound healing
GO:0043125 ErbB-3 class receptor binding
GO:0043624 cellular protein complex disassembly
GO:0045499 chemorepellent activity
GO:0045785 positive regulation of cell adhesion
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048513 animal organ development
GO:0051048 negative regulation of secretion
GO:0051155 positive regulation of striated muscle cell differentiation
GO:0051897 positive regulation of protein kinase B signaling
GO:0055007 cardiac muscle cell differentiation
GO:0055012 ventricular cardiac muscle cell differentiation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060379 cardiac muscle cell myoblast differentiation
GO:0060956 endocardial cell differentiation
GO:0098978 glutamatergic synapse
GO:0099059 integral component of presynaptic active zone membrane
GO:0099061 integral component of postsynaptic density membrane
GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization
GO:0099560 synaptic membrane adhesion
GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation
GO:2000145 regulation of cell motility
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Diseases

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Interactions

80 interactions

InteractorPartnerSourcesPublicationsLink
NRG1ERBB3BioGRID, DIP, HPRD, IntAct10913256 11389077 11555649 17697999 28988771 30523157 31467278 7592681 8702572 9168115 9565587 details
NRG1ERBB2BioGRID, IntAct7592681 details
NRG1EGFRBioGRID, IntAct24658140 25402006 31980649 7730382 details
NRG1MS4A4ABioGRID, IntAct32296183 details
NRG1JAGN1BioGRID, IntAct32296183 details
NRG1LAPTM4BBioGRID, IntAct32296183 details
NRG1CD72BioGRID, IntAct32296183 details
NRG1ASGR2BioGRID, IntAct32296183 details
NRG1PLP1BioGRID, IntAct32296183 details
NRG1TMEM54BioGRID, IntAct32296183 details
NRG1S100A4UniProt30083275 details
NRG1ERBB4BioGRID, HPRD, IntAct10537356 28988771 7721889 8062828 9168115 9565587 details
NRG1LIMK1BioGRID, HPRD9685409 details
NRG1EGFHPRD, IntAct28988771 7730382 details
NRG1CALYBioGRID25349163 details
NRG1IKZF4HPRD15494726 details
NRG1CDC5LBioGRID, MINT20467437 details
NRG1POMT1BioGRID, IntAct26186194 28514442 details
NRG1LEMD3BioGRID, IntAct26186194 28514442 details
NRG1DSEBioGRID, IntAct26186194 28514442 details
NRG1B3GNT2BioGRID, IntAct26186194 28514442 details
NRG1INTS7BioGRID, IntAct26186194 28514442 details
NRG1TMEM39BBioGRID, IntAct26186194 28514442 details
NRG1CNTNAP3BioGRID, IntAct26186194 28514442 details
NRG1LGR4BioGRID, IntAct28514442 details
NRG1SFXN3BioGRID, IntAct26186194 28514442 details
NRG1SLC25A23BioGRID, IntAct26186194 28514442 details
NRG1TM2D3BioGRID, IntAct26186194 28514442 details
NRG1MBOAT7BioGRID, IntAct26186194 28514442 details
NRG1SLC22A18BioGRID, IntAct26186194 28514442 details
NRG1GLMNBioGRID, IntAct26186194 28514442 details
NRG1SLC35B2BioGRID, IntAct26186194 28514442 details
NRG1GALNT11BioGRID, IntAct26186194 28514442 details
NRG1CISD2BioGRID, IntAct26186194 28514442 details
NRG1LARGE2BioGRID, IntAct26186194 28514442 details
NRG1ZDHHC17BioGRID, IntAct26186194 28514442 details
NRG1DNAAF5BioGRID, IntAct26186194 28514442 details
NRG1LSRBioGRID, IntAct26186194 28514442 details
NRG1PGAP1BioGRID, IntAct26186194 28514442 details
NRG1TMEM164BioGRID, IntAct26186194 28514442 details
NRG1TMTC4BioGRID, IntAct26186194 28514442 details
NRG1TMEM63BBioGRID, IntAct26186194 28514442 details
NRG1TUBB3BioGRID, IntAct28514442 details
NRG1SREBF2BioGRID, IntAct26186194 28514442 details
NRG1ATP7BBioGRID, IntAct26186194 28514442 details
NRG1SLC25A16BioGRID, IntAct26186194 28514442 details
NRG1RHOBTB3BioGRID, IntAct26186194 28514442 details
NRG1ADGRL1BioGRID, IntAct26186194 28514442 details
NRG1HS6ST1BioGRID, IntAct26186194 28514442 details
NRG1HLA-DPB1BioGRID, IntAct26186194 28514442 details
NRG1H2BC9BioGRID, IntAct30021884 details
NRG1NRG1IntAct28988771 details
NRG1EREGIntAct28988771 details
NRG1KIAA2013BioGRID26186194 details
NRG1TMTC3BioGRID26186194 details
NRG1POMGNT2BioGRID26186194 details
NRG1SLC38A10BioGRID26186194 details
NRG1NDUFA3BioGRID26186194 details
NRG1SPTLC2BioGRID26186194 details
NRG1RDH11BioGRID26186194 details
NRG1MGAT1BioGRID26186194 details
NRG1HMOX1BioGRID26186194 details
NRG1FAM234BBioGRID26186194 details
NRG1EXTL3BioGRID26186194 details
NRG1NETO2BioGRID26186194 details
NRG1UQCRQBioGRID26186194 details
NRG1DEGS1BioGRID26186194 details
NRG1ABCB10BioGRID26186194 details
NRG1B3GALNT2BioGRID26186194 details
NRG1TMEM181BioGRID26186194 details
NRG1MYO19BioGRID26186194 details
NRG1C1GALT1C1BioGRID26186194 details
NRG1NEK4BioGRID26186194 details
NRG1ABCA3BioGRID26186194 details
NRG1MTCH1BioGRID26186194 details
NRG1OPA3BioGRID26186194 details
NRG1TMEM205BioGRID26186194 details
NRG1RNF130BioGRID26186194 details
NRG1PIGUBioGRID26186194 details
NRG1NRASBioGRID30639242 details