Entity Details

Primary name IRF4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15306
EntryNameIRF4_HUMAN
FullNameInterferon regulatory factor 4
TaxID9606
Evidenceevidence at protein level
Length451
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesIRF4

GO terms

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GOName
GO:0000785 chromatin
GO:0000786 nucleosome
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002376 immune system process
GO:0003700 DNA-binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008134 transcription factor binding
GO:0016020 membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0032733 positive regulation of interleukin-10 production
GO:0032736 positive regulation of interleukin-13 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032753 positive regulation of interleukin-4 production
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0042110 T cell activation
GO:0042832 defense response to protozoan
GO:0043011 myeloid dendritic cell differentiation
GO:0043388 positive regulation of DNA binding
GO:0043565 sequence-specific DNA binding
GO:0043966 histone H3 acetylation
GO:0043967 histone H4 acetylation
GO:0045622 regulation of T-helper cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0072540 T-helper 17 cell lineage commitment
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001346 Interferon regulatory factor DNA-binding domainDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR017855 SMAD-like domain superfamilyFamilyHomologous superfamily
IPR019471 Interferon regulatory factor-3DomainDomain
IPR019817 Interferon regulatory factor, conserved siteSiteConserved site
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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