Entity Details

Primary name KLKB1
Entity type gene
Source Source Link

Details

PrimaryID3818
RefseqGeneNG_012095
SymbolKLKB1
Namekallikrein B1
Chromosome4
Location4q35.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-09-20
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsKLKB1_HUMAN

GO terms

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GOName
GO:0002542 Factor XII activation
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0007597 blood coagulation, intrinsic pathway
GO:0022617 extracellular matrix disassembly
GO:0031638 zymogen activation
GO:0031639 plasminogen activation
GO:0042730 fibrinolysis
GO:0051919 positive regulation of fibrinolysis
GO:0070062 extracellular exosome
GO:2000267 negative regulation of blood coagulation, intrinsic pathway

Diseases

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Disease IDSourceNameDescription
612423 OMIMPrekallikrein deficiency (PKK deficiency)This disorder is a blood coagulation defect. The disease is caused by variants affecting the gene represented in this entry.