Entity Details

Primary name LRP6
Entity type gene
Source Source Link

Details

PrimaryID4040
RefseqGeneNG_016168
SymbolLRP6
NameLDL receptor related protein 6
Chromosome12
Location12p13.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-11-10
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsLRP6_HUMAN

GO terms

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GOName
GO:0001843 neural tube closure
GO:0001933 negative regulation of protein phosphorylation
GO:0003344 pericardium morphogenesis
GO:0005041 low-density lipoprotein particle receptor activity
GO:0005102 signaling receptor binding
GO:0005109 frizzled binding
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0006469 negative regulation of protein kinase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007268 chemical synaptic transmission
GO:0009880 embryonic pattern specification
GO:0009986 cell surface
GO:0014029 neural crest formation
GO:0014033 neural crest cell differentiation
GO:0015026 coreceptor activity
GO:0016021 integral component of membrane
GO:0016055 Wnt signaling pathway
GO:0017147 Wnt-protein binding
GO:0019210 kinase inhibitor activity
GO:0019534 toxin transmembrane transporter activity
GO:0021587 cerebellum morphogenesis
GO:0021794 thalamus development
GO:0021987 cerebral cortex development
GO:0030278 regulation of ossification
GO:0030326 embryonic limb morphogenesis
GO:0030901 midbrain development
GO:0030917 midbrain-hindbrain boundary development
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0034185 apolipoprotein binding
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0035261 external genitalia morphogenesis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042813 Wnt-activated receptor activity
GO:0043025 neuronal cell body
GO:0043434 response to peptide hormone
GO:0044335 canonical Wnt signaling pathway involved in neural crest cell differentiation
GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0045121 membrane raft
GO:0045202 synapse
GO:0045787 positive regulation of cell cycle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046849 bone remodeling
GO:0048596 embryonic camera-type eye morphogenesis
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0060021 roof of mouth development
GO:0060026 convergent extension
GO:0060059 embryonic retina morphogenesis in camera-type eye
GO:0060070 canonical Wnt signaling pathway
GO:0060325 face morphogenesis
GO:0060349 bone morphogenesis
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060535 trachea cartilage morphogenesis
GO:0071397 cellular response to cholesterol
GO:0071542 dopaminergic neuron differentiation
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0071936 coreceptor activity involved in Wnt signaling pathway
GO:0072659 protein localization to plasma membrane
GO:0090009 primitive streak formation
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090118 receptor-mediated endocytosis involved in cholesterol transport
GO:0090244 Wnt signaling pathway involved in somitogenesis
GO:0090245 axis elongation involved in somitogenesis
GO:0098609 cell-cell adhesion
GO:1904886 beta-catenin destruction complex disassembly
GO:1904928 coreceptor activity involved in canonical Wnt signaling pathway
GO:1904948 midbrain dopaminergic neuron differentiation
GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
GO:1990851 Wnt-Frizzled-LRP5/6 complex
GO:1990909 Wnt signalosome

Diseases

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Interactions

70 interactions

InteractorPartnerSourcesPublicationsLink
LRP6AXIN1BioGRID, DIP, HPRD, IntAct12897152 16890161 19107203 20128690 22682247 23892894 23959799 24976009 28966723 details
LRP6WNT3ABioGRID, DIP, HPRD, IntAct12897152 14739301 19910923 21944579 22726442 details
LRP6LRRK2BioGRID, IntAct22899650 27013965 details
LRP6ATP13A2BioGRID, IntAct22645275 details
LRP6GSK3Abhf-ucl, BioGRID, UniProt16365045 30824926 details
LRP6GSK3Bbhf-ucl, BioGRID, HPRD16365045 16890161 19107203 details
LRP6DKK1bhf-ucl, BioGRID, DIP, HPRD, IntAct11357136 11448771 15035989 21944579 21984209 26186194 27322059 28514442 details
LRP6SOSTbhf-ucl, BioGRID, DIP, IntAct, UniProt15908424 21471202 21944579 28514442 details
LRP6LRP6bhf-ucl, BioGRID, DIP, HPRD12897152 21984209 28966723 details
LRP6CKLFBioGRID, IntAct32296183 details
LRP6DKK2DIP, HPRD11357136 11742004 21944579 details
LRP6APOBBioGRID18948618 details
LRP6FZD8BioGRID, HPRD11029007 11448771 15908424 details
LRP6WNT1BioGRID, HPRD11029007 11448771 details
LRP6SERPINF1BioGRID21576363 details
LRP6MDKBioGRID12573468 details
LRP6ANTXR1HPRD, IntAct16564009 details
LRP6ANTXR2HPRD, IntAct16564009 details
LRP6AMMECR1MINT21304492 details
LRP6DAB2MINT22491013 details
LRP6CAPRIN2bhf-ucl, BioGRID18762581 details
LRP6CAV1bhf-ucl, BioGRID16890161 28966723 34079125 details
LRP6CTNNB1bhf-ucl, BioGRID16890161 31262711 details
LRP6EEA1bhf-ucl16890161 details
LRP6RAB11Abhf-ucl16890161 details
LRP6BAMBIbhf-ucl18838381 details
LRP6IGFBP4DIP18528331 details
LRP6PDGFRBDIP21245321 details
LRP6ZNRF3BioGRID, DIP22575959 details
LRP6NPC1BioGRID18948618 details
LRP6WNT5ABioGRID19910923 details
LRP6FZD5BioGRID, HPRD12121999 12857724 details
LRP6LGR4BioGRID24639526 details
LRP6IQGAP1BioGRID24639526 details
LRP6EPN1BioGRID25871009 details
LRP6LRP5BioGRID28966723 details
LRP6ITCHBioGRID28966723 details
LRP6LMBR1LBioGRID31073040 details
LRP6TRAF6BioGRID31262711 details
LRP6TLNRD1HPRD16989816 details
LRP6TMEM17BioGRID, IntAct26638075 details
LRP6MGAT4CBioGRID, IntAct28514442 details
LRP6POMKBioGRID, IntAct26186194 28514442 details
LRP6SCGB1D1BioGRID, IntAct28514442 details
LRP6PARP16BioGRID, IntAct26186194 28514442 details
LRP6DKKL1BioGRID, IntAct28514442 details
LRP6KLK5BioGRID, IntAct28514442 details
LRP6CSNK1A1BioGRID, IntAct28514442 details
LRP6TGIF2LYBioGRID, IntAct28514442 details
LRP6RASD2BioGRID, IntAct26186194 28514442 details
LRP6TAFAZZINBioGRID, IntAct26186194 28514442 details
LRP6ST8SIA4BioGRID, IntAct28514442 details
LRP6FCGRTBioGRID, IntAct28514442 details
LRP6PRSS37BioGRID, IntAct28514442 details
LRP6CHST9BioGRID, IntAct26186194 28514442 details
LRP6ETV6BioGRID, IntAct26186194 28514442 details
LRP6ADAM33BioGRID, IntAct28514442 details
LRP6RASSF1BioGRID, IntAct26186194 28514442 details
LRP6TENT4ABioGRID, IntAct28514442 details
LRP6WNT10BBioGRID, IntAct28514442 details
LRP6GAS8BioGRID26344197 details
LRP6PTPRHBioGRID27880917 details
LRP6NRASBioGRID30194290 details
LRP6KRASBioGRID30194290 details
LRP6B3GAT1BioGRID34079125 details
LRP6ELOVL5BioGRID34079125 details
LRP6GJA1BioGRID34079125 details
LRP6RHOBBioGRID34079125 details
LRP6SEC61BBioGRID34079125 details
LRP6VIRMABioGRID29507755 details