Entity Details

Primary name PDE1C
Entity type gene
Source Source Link

Details

PrimaryID5137
RefseqGeneNG_051183
SymbolPDE1C
Namephosphodiesterase 1C
Chromosome7
Location7p14.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-27
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsPDE1C_HUMAN

GO terms

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GOName
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0005516 calmodulin binding
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0043025 neuronal cell body
GO:0046872 metal ion binding
GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity

Diseases

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Disease IDSourceNameDescription
618140 OMIMDeafness, autosomal dominant, 74 (DFNA74)A form of non-syndromic deafness characterized by progressive, postlingual hearing loss with onset in the third decade of life. The disease is caused by variants affecting the gene represented in this entry.

Interactions

5 interactions

InteractorPartnerSourcesPublicationsLink
PDE1CGSPT2BioGRID, IntAct28514442 details
PDE1CPDE1BBioGRID, IntAct28514442 details
PDE1CPDE1ABioGRID, IntAct28514442 details
PDE1CEGFRBioGRID28065597 details
PDE1CKIF14BioGRID31586073 details