Entity Details

Primary name DGKD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16760
EntryNameDGKD_HUMAN
FullNameDiacylglycerol kinase delta
TaxID9606
Evidenceevidence at protein level
Length1214
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDGKD

GO terms

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GOName
GO:0003951 NAD+ kinase activity
GO:0004143 diacylglycerol kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0006654 phosphatidic acid biosynthetic process
GO:0006897 endocytosis
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
GO:0007275 multicellular organism development
GO:0010033 response to organic substance
GO:0015031 protein transport
GO:0019900 kinase binding
GO:0019932 second-messenger-mediated signaling
GO:0019992 diacylglycerol binding
GO:0030168 platelet activation
GO:0031410 cytoplasmic vesicle
GO:0035556 intracellular signal transduction
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0046339 diacylglycerol metabolic process
GO:0046834 lipid phosphorylation
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0090038 negative regulation of protein kinase C signaling
GO:2000370 positive regulation of clathrin-dependent endocytosis

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR000756 Diacylglycerol kinase, accessory domainDomainDomain
IPR001206 Diacylglycerol kinase, catalytic domainDomainDomain
IPR001660 Sterile alpha motif domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamilyFamilyHomologous superfamily
IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminalFamilyHomologous superfamily
IPR037606 Diacylglycerol kinase delta, SAM domainDomainDomain
IPR037607 Diacylglycerol kinaseFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00144 Phosphatidyl serineDrugbanksmall molecule
DB14001 alpha-Tocopherol succinateDrugbanksmall molecule