Entity Details

Primary name HFE_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ30201
EntryNameHFE_HUMAN
FullNameHereditary hemochromatosis protein
TaxID9606
Evidenceevidence at protein level
Length348
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesHFE

GO terms

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GOName
GO:0002626 negative regulation of T cell antigen processing and presentation
GO:0002725 negative regulation of T cell cytokine production
GO:0005102 signaling receptor binding
GO:0005615 extracellular space
GO:0005654 nucleoplasm
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006879 cellular iron ion homeostasis
GO:0006953 acute-phase response
GO:0007565 female pregnancy
GO:0009897 external side of plasma membrane
GO:0010039 response to iron ion
GO:0010106 cellular response to iron ion starvation
GO:0010628 positive regulation of gene expression
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030509 BMP signaling pathway
GO:0030881 beta-2-microglobulin binding
GO:0031410 cytoplasmic vesicle
GO:0032092 positive regulation of protein binding
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033572 transferrin transport
GO:0034756 regulation of iron ion transport
GO:0039706 co-receptor binding
GO:0045177 apical part of cell
GO:0045178 basal part of cell
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0048471 perinuclear region of cytoplasm
GO:0055037 recycling endosome
GO:0055072 iron ion homeostasis
GO:0065003 protein-containing complex assembly
GO:0071281 cellular response to iron ion
GO:0090277 positive regulation of peptide hormone secretion
GO:0097421 liver regeneration
GO:0098711 iron ion import across plasma membrane
GO:1900121 negative regulation of receptor binding
GO:1900122 positive regulation of receptor binding
GO:1904283 negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:1904434 positive regulation of ferrous iron binding
GO:1904437 positive regulation of transferrin receptor binding
GO:1990357 terminal web
GO:1990459 transferrin receptor binding
GO:1990641 response to iron ion starvation
GO:1990712 HFE-transferrin receptor complex
GO:2000008 regulation of protein localization to cell surface
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
GO:2000272 negative regulation of signaling receptor activity
GO:2000273 positive regulation of signaling receptor activity
GO:2001186 negative regulation of CD8-positive, alpha-beta T cell activation

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR001039 MHC class I alpha chain, alpha1 alpha2 domainsDomainDomain
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR011161 MHC class I-like antigen recognition-likeDomainDomain
IPR011162 MHC classes I/II-like antigen recognition proteinFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR031092 Hereditary hemochromatosis proteinFamilyFamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR037055 MHC class I-like antigen recognition-like superfamilyFamilyHomologous superfamily

Diseases

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