Entity Details

Primary name REN
Entity type gene
Source Source Link

Details

PrimaryID5972
RefseqGeneNG_012122
SymbolREN
Namerenin
Chromosome1
Location1q32.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1988-08-05
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsRENI_HUMAN

GO terms

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GOName
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0002003 angiotensin maturation
GO:0002018 renin-angiotensin regulation of aldosterone production
GO:0004190 aspartic-type endopeptidase activity
GO:0005102 signaling receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0008217 regulation of blood pressure
GO:0008233 peptidase activity
GO:0008584 male gonad development
GO:0009755 hormone-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0035690 cellular response to drug
GO:0035902 response to immobilization stress
GO:0042756 drinking behavior
GO:0043408 regulation of MAPK cascade
GO:0045177 apical part of cell
GO:0048469 cell maturation
GO:0050435 amyloid-beta metabolic process
GO:0051591 response to cAMP
GO:0070305 response to cGMP

Diseases

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Disease IDSourceNameDescription
613092 OMIMFamilial juvenile hyperuricemic nephropathy 2 (HNFJ2)A renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia. The disease is caused by variants affecting the gene represented in this entry.
267430 OMIMRenal tubular dysgenesis (RTD)Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). The disease is caused by variants affecting the gene represented in this entry.

Interactions

11 interactions