Entity Details

Primary name WRN
Entity type gene
Source Source Link

Details

PrimaryID7486
RefseqGeneNG_008870
SymbolWRN
NameWRN RecQ like helicase
Chromosome8
Location8p12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-27
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsWRN_HUMAN

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0000400 four-way junction DNA binding
GO:0000403 Y-form DNA binding
GO:0000405 bubble DNA binding
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000731 DNA synthesis involved in DNA repair
GO:0000781 chromosome, telomeric region
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003682 chromatin binding
GO:0004386 helicase activity
GO:0004527 exonuclease activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0006979 response to oxidative stress
GO:0007420 brain development
GO:0007568 aging
GO:0007569 cell aging
GO:0008408 3'-5' exonuclease activity
GO:0009267 cellular response to starvation
GO:0009378 four-way junction helicase activity
GO:0010225 response to UV-C
GO:0010259 multicellular organism aging
GO:0016607 nuclear speck
GO:0016887 ATP hydrolysis activity
GO:0030145 manganese ion binding
GO:0031297 replication fork processing
GO:0032201 telomere maintenance via semi-conservative replication
GO:0032405 MutLalpha complex binding
GO:0032508 DNA duplex unwinding
GO:0040009 regulation of growth rate
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043005 neuron projection
GO:0043138 3'-5' DNA helicase activity
GO:0044806 G-quadruplex DNA unwinding
GO:0044877 protein-containing complex binding
GO:0051345 positive regulation of hydrolase activity
GO:0051880 G-quadruplex DNA binding
GO:0061749 forked DNA-dependent helicase activity
GO:0061820 telomeric D-loop disassembly
GO:0061821 telomeric D-loop binding
GO:0061849 telomeric G-quadruplex DNA binding
GO:0070337 3'-flap-structured DNA binding
GO:0071480 cellular response to gamma radiation
GO:0090399 replicative senescence
GO:0090656 t-circle formation
GO:0098530 positive regulation of strand invasion
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902570 protein localization to nucleolus
GO:1905773 8-hydroxy-2'-deoxyguanosine DNA binding

Diseases

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Interactions

80 interactions

InteractorPartnerSourcesPublicationsLink
WRNWRNBioGRID, MINT10783163 details
WRNXRCC5BioGRID, HPRD, IntAct, MINT, Molecular Connections10783163 10880505 11328876 12177300 12937274 14734561 21679440 26496610 details
WRNXRCC6BioGRID, HPRD, IntAct, MINT10783163 10880505 11328876 12177300 14734561 26496610 28514442 30585729 details
WRNRPA1BioGRID, HPRD, IntAct, MINT10373438 15735006 15965237 24126761 24332808 26474068 27723720 30279242 details
WRNPARP1BioGRID, HPRD, IntAct, MINT14596914 14734561 details
WRNH2AXBioGRID, HPRD, MINT15733840 20802463 details
WRNRAD52BioGRID, HPRD, IntAct12750383 17118963 details
WRNTERF2BioGRID, HPRD, IntAct12181313 18212065 details
WRNBLMBioGRID, HPRD, IntAct11919194 details
WRNFEN1BioGRID, HPRD, IntAct11598021 12356323 14657243 14688284 16326861 details
WRNTP53BioGRID, HPRD, IntAct11399766 11427532 12080066 15735006 details
WRNSIRT1BioGRID, IntAct, UniProt18203716 19343720 details
WRNRAD51BioGRID, DIP17118963 18562274 details
WRNBRCA1BioGRID, UniProt16714450 24709898 29656893 details
WRNMDC1BioGRID14578343 details
WRNATMBioGRID, HPRD10608806 10839545 11252893 details
WRNATRBioGRID10608806 17118963 22159421 details
WRNPRKDCBioGRID, HPRD10608806 11889123 details
WRNPCNABioGRID, HPRD10871373 12633936 12750383 20600238 details
WRNWRNIP1BioGRID, HPRD11301316 details
WRNCHAF1ABioGRID17173071 details
WRNPOLBBioGRID17173071 details
WRNDHX9BioGRID15995249 17498979 details
WRNATRXBioGRID17118963 details
WRNRAD54BBioGRID17118963 details
WRNCDKN2ABioGRID, HPRD15355988 details
WRNSUMO1BioGRID16524884 details
WRNSUMO2BioGRID16524884 details
WRNPOLKBioGRID25294835 details
WRNRAD9ABioGRID22002307 details
WRNRAD1BioGRID22002307 details
WRNBARD1BioGRID16714450 details
WRNMDM2BioGRID30532073 details
WRNMIB1BioGRID32652764 details
WRNPRKAR1BHPRD12067711 details
WRNNLRP2MINT15733840 details
WRNVCPBioGRID, HPRD, IntAct12937274 15037256 details
WRNUBCMINT18588880 details
WRNRPA2BioGRID, MINT20802463 24126761 24332808 30279242 details
WRNRPA3BioGRID, IntAct, MINT24126761 24332808 27173435 30279242 unassigned1312 details
WRNARL3BioGRID, IntAct27173435 unassigned1312 details
WRNPOLLBioGRID, IntAct27173435 unassigned1312 details
WRNSUPT16HBioGRID, IntAct27173435 unassigned1312 details
WRNCBX5DIP25931448 details
WRNPOLR1CBioGRID, HPRD11971179 details
WRNNBNBioGRID15733840 20600238 details
WRNCDC5LBioGRID16223718 details
WRNPMLBioGRID21639834 details
WRNNKX2-1BioGRID28192407 details
WRNHERC2BioGRID30279242 details
WRNHDAC1BioGRID27672210 details
WRNHDAC2BioGRID27672210 details
WRNMOV10BioGRID29395067 details
WRNNXF1BioGRID29395067 details
WRNCPSF1BioGRID29395067 details
WRNSMG7BioGRID29395067 details
WRNILF3BioGRID29395067 details
WRNSHLD2BioGRID30154076 details
WRNPOLD2HPRD11027336 details
WRNWDR48BioGRID, IntAct19615732 details
WRNCREBBPBioGRID, UniProt18203716 details
WRNE2F3MINT22157815 details
WRNTINF2BioGRID, IntAct26496610 details
WRNSKAP1BioGRID, IntAct26186194 28514442 details
WRNKIAA0930BioGRID, IntAct26186194 28514442 details
WRNSUV39H1DIP25931448 details
WRNTMPODIP25931448 details
WRNCTNNBL1BioGRID, IntAct30021884 details
WRNESR1BioGRID, IntAct31527615 details
WRNRNF146MINT21799911 details
WRNNTRK1BioGRID25921289 details
WRNNR2C2BioGRID30463901 details
WRNH4C1BioGRID30804502 details
WRNEIF4A3BioGRID29395067 details
WRNLRRC31BioGRID33005030 details
WRNKIF14BioGRID31586073 details
WRNDTX2BioGRID32937373 details
WRNDHX8BioGRID34079125 details
WRNRPL31BioGRID34079125 details
WRNUTP4BioGRID34079125 details