Entity Details

Primary name PAN2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ504Q3
EntryNamePAN2_HUMAN
FullNamePAN2-PAN3 deadenylation complex catalytic subunit PAN2
TaxID9606
Evidenceevidence at protein level
Length1202
SequenceStatuscomplete
DateCreated2007-03-20
DateModified2021-06-02

Ontological Relatives

GenesPAN2

GO terms

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GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000932 P-body
GO:0003676 nucleic acid binding
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006397 mRNA processing
GO:0006508 proteolysis
GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly
GO:0031251 PAN complex
GO:0046872 metal ion binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR013520 Exonuclease, RNase T/DNA polymerase IIIDomainDomain
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR028881 PAN2 domainDomainDomain
IPR028889 Ubiquitin specific protease domainDomainDomain
IPR030843 PAN2-PAN3 deadenylation complex catalytic subunit PAN2FamilyFamily
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily

Diseases

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Interactions

49 interactions

InteractorPartnerSourcesPublicationsLink
PAN2_HUMANTNR6A_HUMANBioGRID21984185 details
PAN2_HUMANPABP1_HUMANBioGRID, HPRD14583602 17785442 23398456 29395067 31104843 details
PAN2_HUMANCTIP_HUMANBioGRID33097710 details
PAN2_HUMANATM_HUMANBioGRID33097710 details
PAN2_HUMANHOIL1_HUMANBioGRID23105109 details
PAN2_HUMANDYL1_HUMANHPRD11148209 details
PAN2_HUMANTRI35_HUMANBioGRID23105109 details
PAN2_HUMANR144B_HUMANBioGRID23105109 details
PAN2_HUMANPAN3_HUMANBioGRID, DIP, HPRD, IntAct, UniProt14583602 19615732 23398456 24880343 details
PAN2_HUMANTWF2_HUMANIntAct17353931 details
PAN2_HUMANTNR6C_HUMANBioGRID, DIP, UniProt21981923 21984184 21984185 29395067 details
PAN2_HUMANPCGF3_HUMANBioGRID, IntAct27173435 unassigned1312 details
PAN2_HUMANLSM1_HUMANBioGRID, IntAct27173435 unassigned1312 details
PAN2_HUMANP121C_HUMANIntActunassigned1312 details
PAN2_HUMANNUP50_HUMANBioGRID, IntAct27173435 unassigned1312 details
PAN2_HUMANHELZ_HUMANBioGRID, IntAct27173435 unassigned1312 details
PAN2_HUMAN4ET_HUMANBioGRID, IntAct27173435 unassigned1312 details
PAN2_HUMANCOE3_HUMANBioGRID, IntAct27173435 unassigned1312 details
PAN2_HUMANCTBP1_HUMANBioGRID, IntAct27173435 unassigned1312 details
PAN2_HUMANCBP_HUMANBioGRID, IntAct27173435 unassigned1312 details
PAN2_HUMANPCGF5_HUMANBioGRID, IntAct27173435 unassigned1312 details
PAN2_HUMANP121A_HUMANBioGRID, IntAct27173435 unassigned1312 details
PAN2_HUMANCO039_HUMANBioGRID, IntAct27173435 unassigned1312 details
PAN2_HUMANSWAHA_HUMANIntActunassigned1312 details
PAN2_HUMANRING2_HUMANBioGRID, IntAct27173435 unassigned1312 details
PAN2_HUMANNISCH_HUMANBioGRID, IntAct27173435 unassigned1312 details
PAN2_HUMANMARF1_HUMANBioGRID, IntAct27173435 unassigned1312 details
PAN2_HUMANARI3A_HUMANBioGRID, IntAct27173435 unassigned1312 details
PAN2_HUMANLZTS2_HUMANBioGRID23398456 29395067 details
PAN2_HUMANK1671_HUMANBioGRID, IntAct27173435 unassigned1312 details
PAN2_HUMANMEX3C_HUMANBioGRID26471122 details
PAN2_HUMANTTP_HUMANBioGRID21078877 29395067 details
PAN2_HUMANERF_HUMANBioGRID, IntAct27173435 unassigned1312 details
PAN2_HUMANZEB1_HUMANBioGRID29119051 details
PAN2_HUMANSNAI1_HUMANBioGRID31911859 details
PAN2_HUMANGRRE1_HUMANBioGRID29395067 details
PAN2_HUMANMEX3B_HUMANBioGRID29395067 details
PAN2_HUMANPAIP2_HUMANBioGRID29395067 details
PAN2_HUMANYTHD3_HUMANBioGRID29395067 details
PAN2_HUMANCNOT9_HUMANBioGRID29395067 details
PAN2_HUMANTNR6B_HUMANBioGRID29395067 details
PAN2_HUMANTOB1_HUMANBioGRID17785442 details
PAN2_HUMANTOB2_HUMANBioGRID17785442 details
PAN2_HUMANSTING_HUMANBioGRID27801882 details
PAN2_HUMANCTNB1_HUMANBioGRID30323974 details
PAN2_HUMANYTHD2_HUMANBioGRID29395067 details
PAN2_HUMANPRC2A_HUMANBioGRID29395067 details
PAN2_HUMANMKRN2_HUMANBioGRID29395067 details
PAN2_HUMANYTHD1_HUMANBioGRID29395067 details