Entity Details

Primary name FZD4
Entity type gene
Source Source Link

Details

PrimaryID8322
RefseqGeneNG_011752
SymbolFZD4
Namefrizzled class receptor 4
Chromosome11
Location11q14.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-02-20
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsFZD4_HUMAN

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001570 vasculogenesis
GO:0004896 cytokine receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007605 sensory perception of sound
GO:0009986 cell surface
GO:0010812 negative regulation of cell-substrate adhesion
GO:0016055 Wnt signaling pathway
GO:0017147 Wnt-protein binding
GO:0019955 cytokine binding
GO:0030165 PDZ domain binding
GO:0030182 neuron differentiation
GO:0030425 dendrite
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031625 ubiquitin protein ligase binding
GO:0031987 locomotion involved in locomotory behavior
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035426 extracellular matrix-cell signaling
GO:0035567 non-canonical Wnt signaling pathway
GO:0038023 signaling receptor activity
GO:0042701 progesterone secretion
GO:0042803 protein homodimerization activity
GO:0042813 Wnt-activated receptor activity
GO:0043507 positive regulation of JUN kinase activity
GO:0044877 protein-containing complex binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046982 protein heterodimerization activity
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0060070 canonical Wnt signaling pathway
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061024 membrane organization
GO:0061299 retina vasculature morphogenesis in camera-type eye
GO:0061301 cerebellum vasculature morphogenesis
GO:0061304 retinal blood vessel morphogenesis
GO:0071300 cellular response to retinoic acid
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0098978 glutamatergic synapse
GO:0110135 Norrin signaling pathway
GO:0150012 positive regulation of neuron projection arborization
GO:1990830 cellular response to leukemia inhibitory factor

Diseases

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Disease IDSourceNameDescription
133780 OMIMVitreoretinopathy, exudative 1 (EVR1)A disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. Clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease related abnormality is an arc of avascular retina in the extreme temporal periphery. In many ways the disease resembles retinopathy of prematurity but there is no evidence of prematurity or small birth weight in the patient history. The disease is caused by variants affecting the gene represented in this entry.