Entity Details

Primary name SETMR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ53H47
EntryNameSETMR_HUMAN
FullNameHistone-lysine N-methyltransferase SETMAR
TaxID9606
Evidenceevidence at protein level
Length684
SequenceStatuscomplete
DateCreated2006-10-31
DateModified2021-06-02

Ontological Relatives

GenesSETMAR

GO terms

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GOName
GO:0000014 single-stranded DNA endodeoxyribonuclease activity
GO:0000729 DNA double-strand break processing
GO:0000737 DNA catabolic process, endonucleolytic
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0004519 endonuclease activity
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0008270 zinc ion binding
GO:0008283 cell population proliferation
GO:0010452 histone H3-K36 methylation
GO:0015074 DNA integration
GO:0031297 replication fork processing
GO:0035861 site of double-strand break
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0042803 protein homodimerization activity
GO:0044547 DNA topoisomerase binding
GO:0044774 mitotic DNA integrity checkpoint signaling
GO:0046975 histone methyltransferase activity (H3-K36 specific)
GO:0051568 histone H3-K4 methylation
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0097676 histone H3-K36 dimethylation
GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining
GO:2001251 negative regulation of chromosome organization

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR001214 SET domainDomainDomain
IPR001888 Transposase, type 1FamilyFamily
IPR003616 Post-SET domainDomainDomain
IPR007728 Pre-SET domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR041426 Mos1 transposase, HTH domainDomainDomain

Diseases

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