Entity Details

Primary name FILA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ5D862
EntryNameFILA2_HUMAN
FullNameFilaggrin-2
TaxID9606
Evidenceevidence at protein level
Length2391
SequenceStatuscomplete
DateCreated2008-04-29
DateModified2021-06-02

Ontological Relatives

GenesFLG2

GO terms

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GOName
GO:0001533 cornified envelope
GO:0005198 structural molecule activity
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0007155 cell adhesion
GO:0036457 keratohyalin granule
GO:0043312 neutrophil degranulation
GO:0046914 transition metal ion binding
GO:0048730 epidermis morphogenesis
GO:0061436 establishment of skin barrier
GO:1904724 tertiary granule lumen

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic granule

Domains

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DomainNameCategoryType
IPR001751 S100/Calbindin-D9k, conserved siteSiteConserved site
IPR002048 EF-hand domainDomainDomain
IPR003303 FilaggrinFamilyFamily
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR013787 S100/CaBP-9k-type, calcium binding, subdomainDomainDomain
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR034325 S-100DomainDomain

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
FILA2_HUMANHS90A_HUMANBioGRID31273033 details