Entity Details

Primary name NTH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78549
EntryNameNTH_HUMAN
FullNameEndonuclease III-like protein 1
TaxID9606
Evidenceevidence at protein level
Length312
SequenceStatuscomplete
DateCreated2003-02-28
DateModified2021-06-02

Ontological Relatives

GenesNTHL1

GO terms

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GOName
GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0004519 endonuclease activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0006285 base-excision repair, AP site formation
GO:0006287 base-excision repair, gap-filling
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0019104 DNA N-glycosylase activity
GO:0045008 depyrimidination
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity

Subcellular Location

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Subcellular Location
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000445 Helix-hairpin-helix motifSiteConserved site
IPR003265 HhH-GPD domainDomainDomain
IPR003651 Endonuclease III-like, iron-sulphur cluster loop motifSiteConserved site
IPR004036 Endonuclease III-like, conserved site-2SiteConserved site
IPR011257 DNA glycosylaseFamilyHomologous superfamily
IPR023170 Helix-hairpin-helix, base-excision DNA repair, C-terminalFamilyHomologous superfamily
IPR030841 Endonuclease III-like protein 1FamilyFamily

Diseases

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Disease IDSourceNameDescription
616415 OMIMFamilial adenomatous polyposis 3 (FAP3)A form of familial adenomatous polyposis, a condition characterized by the development of multiple colorectal adenomatous polyps, benign neoplasms derived from glandular epithelium. Some affected individuals may develop colorectal carcinoma. The disease is caused by variants affecting the gene represented in this entry.

Interactions

5 interactions