Entity Details

Primary name MYRF
Entity type gene
Source Source Link

Details

PrimaryID745
RefseqGeneNG_047038
SymbolMYRF
Namemyelin regulatory factor
Chromosome11
Location11q12.2
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2000-08-23
ModificationDate2021-06-13

Ontological Relatives

UniProt IDsMYRF_HUMAN

GO terms

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GOName
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0008233 peptidase activity
GO:0014003 oligodendrocyte development
GO:0016021 integral component of membrane
GO:0016540 protein autoprocessing
GO:0022010 central nervous system myelination
GO:0031643 positive regulation of myelination
GO:0032286 central nervous system myelin maintenance
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048709 oligodendrocyte differentiation

Diseases

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Disease IDSourceNameDescription
618280 OMIMCardiac-urogenital syndrome (CUGS)An autosomal dominant syndrome characterized by partial anomalous pulmonary venous return, tracheal anomalies, pulmonary hypoplasia, congenital diaphragmatic hernia, thyroid fibrosis, thymic involution, cleft spleen, penoscrotal hypospadias, and cryptorchidism. The disease is caused by variants affecting the gene represented in this entry.
618113 OMIMEncephalitis/encephalopathy, mild, with reversible myelin vacuolization (MMERV)An autosomal dominant disease characterized by episodes of acute encephalitis associated with impaired consciousness, delirious behavior, seizures, and reversible splenial lesions observed on diffusion magnetic resonance imaging. Most patients completely recover and there are no neurologic sequelae. MMERV occurs in children and is frequently associated with a trigger, such as a febrile illness. The disease may be caused by variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MYRFMYRFDIP23966832 details
MYRFNRASBioGRID30639242 details