Entity Details

Primary name SLN14_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP0C7P3
EntryNameSLN14_HUMAN
FullNameProtein SLFN14
TaxID9606
Evidenceevidence at protein level
Length912
SequenceStatuscomplete
DateCreated2008-07-01
DateModified2021-06-02

Ontological Relatives

GenesSLFN14

GO terms

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GOName
GO:0004521 endoribonuclease activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006402 mRNA catabolic process
GO:0016075 rRNA catabolic process
GO:0036345 platelet maturation
GO:0043022 ribosome binding
GO:0071286 cellular response to magnesium ion
GO:0071287 cellular response to manganese ion
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR007421 Schlafen, AlbA_2 domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR029677 Schlafen family member 14FamilyFamily
IPR029684 Schlafen familyFamilyFamily
IPR038461 Schlafen, AlbA_2 domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616913 OMIMBleeding disorder, platelet-type 20 (BDPLT20)A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. BDPLT20 is characterized by moderate thrombocytopenia and platelet secretion defects. Inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.

Interactions

0 interactions

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