Entity Details

Primary name CLC7A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9BXN2
EntryNameCLC7A_HUMAN
FullNameC-type lectin domain family 7 member A
TaxID9606
Evidenceevidence at protein level
Length247
SequenceStatuscomplete
DateCreated2006-12-12
DateModified2021-06-02

Ontological Relatives

GenesCLEC7A

GO terms

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GOName
GO:0001872 (1->3)-beta-D-glucan binding
GO:0002366 leukocyte activation involved in immune response
GO:0002732 positive regulation of dendritic cell cytokine production
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006910 phagocytosis, recognition
GO:0006954 inflammatory response
GO:0008037 cell recognition
GO:0008284 positive regulation of cell population proliferation
GO:0009756 carbohydrate mediated signaling
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0016021 integral component of membrane
GO:0016046 detection of fungus
GO:0030246 carbohydrate binding
GO:0030335 positive regulation of cell migration
GO:0031334 positive regulation of protein-containing complex assembly
GO:0032491 detection of molecule of fungal origin
GO:0032729 positive regulation of interferon-gamma production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0032930 positive regulation of superoxide anion generation
GO:0038187 pattern recognition receptor activity
GO:0042110 T cell activation
GO:0042287 MHC protein binding
GO:0042802 identical protein binding
GO:0042832 defense response to protozoan
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 innate immune response
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0046872 metal ion binding
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050766 positive regulation of phagocytosis
GO:0051251 positive regulation of lymphocyte activation
GO:0051712 positive regulation of killing of cells of other organism
GO:0060267 positive regulation of respiratory burst
GO:0071226 cellular response to molecule of fungal origin
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:0090303 positive regulation of wound healing
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1903431 positive regulation of cell maturation

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR001304 C-type lectin-likeDomainDomain
IPR016186 C-type lectin-like/link domain superfamilyFamilyHomologous superfamily
IPR016187 C-type lectin foldFamilyHomologous superfamily
IPR033992 Natural killer cell receptor-like, C-type lectin-like domainDomainDomain
IPR042808 C-type lectin domain family 7 member AFamilyFamily

Diseases

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Disease IDSourceNameDescription
613108 OMIMCandidiasis, familial, 4 (CANDF4)A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. The disease may be caused by variants affecting the gene represented in this entry.

Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
CLC7A_HUMANSYNE4_HUMANBioGRID, IntAct, MINT21516116 25416956 details
CLC7A_HUMANBNI3L_HUMANBioGRID, IntAct, MINT21516116 25416956 32296183 details
CLC7A_HUMANCH60_HUMANBioGRID, IntAct21988832 details
CLC7A_HUMANAIP_HUMANBioGRID, IntAct21988832 details
CLC7A_HUMANRANB9_HUMANBioGRID, IntAct21988832 details
CLC7A_HUMANPTTG_HUMANBioGRID, IntAct25416956 32296183 details
CLC7A_HUMANILRL1_HUMANBioGRID, IntAct25416956 details
CLC7A_HUMANBNIP3_HUMANBioGRID, IntAct25416956 32296183 details
CLC7A_HUMANOCLN_HUMANBioGRID, IntAct25416956 details
CLC7A_HUMANKTN1_HUMANBioGRID, IntAct25416956 details
CLC7A_HUMANJAGN1_HUMANBioGRID, IntAct25416956 details
CLC7A_HUMANTMM79_HUMANBioGRID, IntAct25416956 31515488 32296183 details
CLC7A_HUMANADA33_HUMANBioGRID, IntAct25416956 32296183 details
CLC7A_HUMANSMIM3_HUMANBioGRID, IntAct25416956 32296183 details
CLC7A_HUMANTMPS4_HUMANBioGRID, IntAct25416956 details
CLC7A_HUMANNINJ2_HUMANBioGRID, IntAct25416956 details
CLC7A_HUMANCLC7A_HUMANBioGRID, IntAct25416956 32296183 details
CLC7A_HUMANZFPL1_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANOLFM4_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANCTXN3_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANSC22A_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANUPK2_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANSGCB_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANHG2A_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANOPRM_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANTMPS2_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANAR13B_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANCD53_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANSAR1A_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANCXB1_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANINGR2_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANNEMP1_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANFCGR1_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANSPIT1_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANFNDC9_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANTLCD4_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANCXCL9_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANNRAC_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANNKG2A_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANNSG2_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANASGR2_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANTEX29_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANSUSD3_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANVISTA_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANIF3M_HUMANBioGRID, IntAct32296183 details
CLC7A_HUMANCALM1_HUMANBioGRID25416956 details
CLC7A_HUMANCALM2_HUMANBioGRID25416956 details
CLC7A_HUMANCALM3_HUMANBioGRID25416956 details
CLC7A_HUMANFAM3A_HUMANBioGRID25416956 details
CLC7A_HUMANRHOU_HUMANBioGRID26598620 details
CLC7A_HUMANTLR2_HUMANBioGRID21899704 details
CLC7A_HUMANSOCS1_HUMANBioGRID21899704 29991678 details