Entity Details

Primary name P63_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H3D4
EntryNameP63_HUMAN
FullNameTumor protein 63
TaxID9606
Evidenceevidence at protein level
Length680
SequenceStatuscomplete
DateCreated2005-01-04
DateModified2021-06-02

Ontological Relatives

GenesTP63

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001501 skeletal system development
GO:0001736 establishment of planar polarity
GO:0002039 p53 binding
GO:0002064 epithelial cell development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005791 rough endoplasmic reticulum
GO:0006338 chromatin remodeling
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007219 Notch signaling pathway
GO:0007283 spermatogenesis
GO:0007499 ectoderm and mesoderm interaction
GO:0007569 cell aging
GO:0008283 cell population proliferation
GO:0009954 proximal/distal pattern formation
GO:0010259 multicellular organism aging
GO:0010481 epidermal cell division
GO:0010482 regulation of epidermal cell division
GO:0010838 positive regulation of keratinocyte proliferation
GO:0030216 keratinocyte differentiation
GO:0030425 dendrite
GO:0030859 polarized epithelial cell differentiation
GO:0031069 hair follicle morphogenesis
GO:0032991 protein-containing complex
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0036342 post-anal tail morphogenesis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043589 skin morphogenesis
GO:0045617 negative regulation of keratinocyte differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048485 sympathetic nervous system development
GO:0048807 female genitalia morphogenesis
GO:0050699 WW domain binding
GO:0051262 protein tetramerization
GO:0051402 neuron apoptotic process
GO:0060197 cloacal septation
GO:0060513 prostatic bud formation
GO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0061436 establishment of skin barrier
GO:0097371 MDM2/MDM4 family protein binding
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902808 positive regulation of cell cycle G1/S phase transition
GO:1904674 positive regulation of somatic stem cell population maintenance
GO:1904888 cranial skeletal system development
GO:2000271 positive regulation of fibroblast apoptotic process
GO:2000381 negative regulation of mesoderm development
GO:2000773 negative regulation of cellular senescence
GO:2001235 positive regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001660 Sterile alpha motif domainDomainDomain
IPR002117 p53 tumour suppressor familyFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR010991 p53, tetramerisation domainDomainDomain
IPR011615 p53, DNA-binding domainDomainDomain
IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR032645 Tumour protein p63FamilyFamily
IPR036674 p53-like tetramerisation domain superfamilyFamilyHomologous superfamily
IPR037611 Tumour protein p63, SAM domainDomainDomain

Diseases

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Disease IDSourceNameDescription
103285 OMIMAcro-dermato-ungual-lacrimal-tooth syndrome (ADULT syndrome)A form of ectodermal dysplasia. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ADULT syndrome involves ectrodactyly, syndactyly, finger- and toenail dysplasia, hypoplastic breasts and nipples, intensive freckling, lacrimal duct atresia, frontal alopecia, primary hypodontia and loss of permanent teeth. ADULT syndrome differs significantly from EEC3 syndrome by the absence of facial clefting. Inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.
106260 OMIMAnkyloblepharon-ectodermal defects-cleft lip/palate (AEC)An autosomal dominant condition characterized by congenital ectodermal dysplasia with coarse, wiry, sparse hair, dystrophic nails, slight hypohidrosis, scalp infections, ankyloblepharon filiform adnatum, maxillary hypoplasia, hypodontia and cleft lip/palate. The disease is caused by variants affecting the gene represented in this entry.
618149 OMIMOrofacial cleft 8 (OFC8)A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. The disease is caused by variants affecting the gene represented in this entry.
604292 OMIMEctrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3)A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal dominant syndrome characterized by ectrodactyly of hands and feet, ectodermal dysplasia and facial clefting. The disease is caused by variants affecting the gene represented in this entry.
605289 OMIMSplit-hand/foot malformation 4 (SHFM4)A limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting. The disease is caused by variants affecting the gene represented in this entry.
129400 OMIMRapp-Hodgkin syndrome (RHS)A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Characterized by the combination of anhidrotic ectodermal dysplasia, cleft lip, and cleft palate. The clinical syndrome is comprised of a characteristic facies (narrow nose and small mouth), wiry, slow-growing, and uncombable hair, sparse eyelashes and eyebrows, obstructed lacrimal puncta/epiphora, bilateral stenosis of external auditory canals, microsomia, hypodontia, cone-shaped incisors, enamel hypoplasia, dystrophic nails, and cleft lip/cleft palate. RHS inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.
603543 OMIMLimb-mammary syndrome (LMS)Characterized by ectrodactyly, cleft palate and mammary-gland abnormalities. The disease is caused by variants affecting the gene represented in this entry.

Interactions

88 interactions

InteractorPartnerSourcesPublicationsLink
P63_HUMANASPP1_HUMANHPRD, MINT14729977 details
P63_HUMANYAP1_HUMANBioGRID, MINT11278685 27780825 details
P63_HUMANROAA_HUMANBioGRID, HPRD, IntAct12692135 20085233 details
P63_HUMANP63_HUMANBioGRID, DIP, HPRD, IntAct10373484 19815500 20085233 21335238 21464285 details
P63_HUMANCABL1_HUMANMINT20559324 details
P63_HUMANBAG6_HUMANBioGRID, IntAct21988832 details
P63_HUMANPINX1_HUMANBioGRID, IntAct21988832 details
P63_HUMANCCNC_HUMANBioGRID, IntAct21988832 details
P63_HUMANGLR_HUMANBioGRID, IntAct21988832 details
P63_HUMANHPT_HUMANBioGRID, IntAct21988832 details
P63_HUMANHEMO_HUMANBioGRID, IntAct21988832 details
P63_HUMANITIH4_HUMANBioGRID, IntAct21988832 details
P63_HUMANA1AG1_HUMANBioGRID, IntAct21988832 details
P63_HUMANCSN6_HUMANBioGRID, IntAct21988832 details
P63_HUMANS35A3_HUMANBioGRID, IntAct21988832 details
P63_HUMANNPS3A_HUMANBioGRID, IntAct21988832 details
P63_HUMANPIN1_HUMANBioGRID, IntAct21741598 32296183 details
P63_HUMANHIPK2_HUMANBioGRID, HPRD, I2D11925430 21602882 details
P63_HUMANPELI2_HUMANBioGRID, IntAct32296183 details
P63_HUMANMCRS1_HUMANBioGRID, IntAct32296183 details
P63_HUMANPELI1_HUMANBioGRID, IntAct32296183 details
P63_HUMANUBS3A_HUMANBioGRID, IntAct32296183 details
P63_HUMANP73_HUMANBioGRID, DIP, HPRD, IntAct10373484 11238924 17446929 19815500 22252508 28514442 details
P63_HUMANITCH_HUMANBioGRID, DIP16908849 20855944 22935697 23370280 25485500 details
P63_HUMANIASPP_HUMANDIP18275817 details
P63_HUMANASPP2_HUMANDIP18275817 details
P63_HUMANRACK1_HUMANBioGRID, IntAct12692135 15467455 details
P63_HUMANB2MG_HUMANIntAct12692135 details
P63_HUMANCTNB1_HUMANIntAct12692135 details
P63_HUMANERAL1_HUMANIntAct12692135 details
P63_HUMANGNDS_HUMANIntAct12692135 details
P63_HUMANSCAF4_HUMANBioGRID, IntAct12692135 details
P63_HUMANEMX1_HUMANBioGRID, IntAct20211142 details
P63_HUMANFBW1A_HUMANBioGRID17965458 details
P63_HUMANMDM2_HUMANBioGRID11714701 20571051 21088494 25417702 details
P63_HUMANMDM4_HUMANBioGRID21088494 details
P63_HUMANWWP1_HUMANBioGRID18806757 20951678 details
P63_HUMANCDN2A_HUMANBioGRID15367673 details
P63_HUMANARF_HUMANBioGRID15367673 details
P63_HUMANUBC9_HUMANBioGRID15539951 15611636 details
P63_HUMANDAXX_HUMANBioGRID12954772 15339933 details
P63_HUMANPML_HUMANBioGRID16007146 details
P63_HUMANZN363_HUMANBioGRID23235527 details
P63_HUMANEP300_HUMANBioGRID, HPRD15965232 23589370 25911675 30986748 details
P63_HUMANKAT2B_HUMANBioGRID15965232 22575646 details
P63_HUMANATF3_HUMANBioGRID24554706 details
P63_HUMANCDC20_HUMANBioGRID29735662 details
P63_HUMANCSK21_HUMANBioGRID12393879 details
P63_HUMANCSK22_HUMANBioGRID12393879 details
P63_HUMANCSK2B_HUMANBioGRID12393879 details
P63_HUMANTDG_HUMANBioGRID18951877 details
P63_HUMANP53_HUMANBioGRID, HPRD, IntAct11238924 19345189 21741598 22575646 24554706 25417702 details
P63_HUMANSMAD2_HUMANIntAct19345189 21741598 details
P63_HUMANHNRPK_HUMANBioGRID, IntAct20085233 details
P63_HUMANHNRPQ_HUMANBioGRID, IntAct20085233 details
P63_HUMANFUS_HUMANBioGRID, IntAct20085233 details
P63_HUMANSATB2_HUMANMINT20829881 details
P63_HUMANKPCD_HUMANMINT26112605 details
P63_HUMANTF65_HUMANBioGRID22020940 details
P63_HUMANBRCA1_HUMANBioGRID21363924 24556685 details
P63_HUMANIKKA_HUMANBioGRID20145131 details
P63_HUMANIKKB_HUMANBioGRID20145131 details
P63_HUMANFBXW7_HUMANBioGRID20571051 details
P63_HUMAN1433S_HUMANBioGRID15467455 details
P63_HUMANSUMO1_HUMANBioGRID15539951 details
P63_HUMANUBE4B_HUMANBioGRID18418053 details
P63_HUMANWWOX_HUMANBioGRID23370280 details
P63_HUMANETV4_HUMANBioGRID21150337 details
P63_HUMANCEBPB_HUMANBioGRID21150337 details
P63_HUMANNFYA_HUMANBioGRID21150337 details
P63_HUMANNFKB1_HUMANBioGRID21150337 details
P63_HUMANSTK11_HUMANBioGRID21150337 details
P63_HUMANR144B_HUMANBioGRID23128396 details
P63_HUMANHIF1A_HUMANBioGRID11971180 details
P63_HUMANCDC16_HUMANBioGRID29735662 details
P63_HUMANANC2_HUMANBioGRID29735662 details
P63_HUMANSTXB4_HUMANBioGRID29735662 details
P63_HUMANKCTD5_HUMANBioGRID29782646 details
P63_HUMANPITX1_HUMANBioGRID30713093 details
P63_HUMANITF2_HUMANBioGRID30986748 details
P63_HUMANCRBN_HUMANBioGRID31591562 details
P63_HUMANHDAC2_HUMANBioGRID31591562 details
P63_HUMANUBP8_HUMANBioGRID31511647 details
P63_HUMANISG15_HUMANBioGRID33024031 details
P63_HUMANUBP28_HUMANBioGRID32128997 details
P63_HUMANGRB2_HUMANHPRD8695800 details
P63_HUMAN2A5A_HUMANHPRD12086851 details
P63_HUMANWT1_HUMANHPRD10744705 details