Entity Details

Primary name LEPR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48357
EntryNameLEPR_HUMAN
FullNameLeptin receptor
TaxID9606
Evidenceevidence at protein level
Length1165
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesLEPR

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001934 positive regulation of protein phosphorylation
GO:0004888 transmembrane signaling receptor activity
GO:0004896 cytokine receptor activity
GO:0005576 extracellular region
GO:0005977 glycogen metabolic process
GO:0006112 energy reserve metabolic process
GO:0006909 phagocytosis
GO:0007166 cell surface receptor signaling pathway
GO:0007275 multicellular organism development
GO:0008203 cholesterol metabolic process
GO:0009897 external side of plasma membrane
GO:0010507 negative regulation of autophagy
GO:0014009 glial cell proliferation
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0017046 peptide hormone binding
GO:0019221 cytokine-mediated signaling pathway
GO:0019953 sexual reproduction
GO:0019955 cytokine binding
GO:0030217 T cell differentiation
GO:0033210 leptin-mediated signaling pathway
GO:0038021 leptin receptor activity
GO:0042593 glucose homeostasis
GO:0042802 identical protein binding
GO:0043235 receptor complex
GO:0044321 response to leptin
GO:0045721 negative regulation of gluconeogenesis
GO:0046850 regulation of bone remodeling
GO:0051049 regulation of transport
GO:0051346 negative regulation of hydrolase activity
GO:0060259 regulation of feeding behavior
GO:0097009 energy homeostasis
GO:0098868 bone growth
GO:0120162 positive regulation of cold-induced thermogenesis
GO:0150104 transport across blood-brain barrier

Subcellular Location

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Subcellular Location
Basolateral cell membrane
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003529 Long hematopoietin receptor, Gp130 family 2, conserved siteSiteConserved site
IPR003531 Short hematopoietin receptor, family 1, conserved siteSiteConserved site
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR010457 Immunoglobulin C2-set-like, ligand-bindingDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015752 Leptin receptorFamilyFamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR041182 Leptin receptor, immunoglobulin-like domainDomainDomain

Diseases

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Disease IDSourceNameDescription
614963 OMIMLeptin receptor deficiency (LEPRD)A rare disease characterized by normal levels of serum leptin, hyperphagia and severe obesity from an early age. Additional features include alterations in immune function, and delayed puberty due to hypogonadotropic hypogonadism. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB05098 LeptinDrugbanksmall molecule
DB09046 MetreleptinDrugbankbiotech