Entity Details

Primary name MPCP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ00325
EntryNameMPCP_HUMAN
FullNamePhosphate carrier protein, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length362
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesSLC25A3

GO terms

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GOName
GO:0005315 inorganic phosphate transmembrane transporter activity
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005887 integral component of plasma membrane
GO:0015317 phosphate:proton symporter activity
GO:0016020 membrane
GO:0031305 integral component of mitochondrial inner membrane
GO:0035435 phosphate ion transmembrane transport
GO:0044877 protein-containing complex binding
GO:0070062 extracellular exosome
GO:1990547 mitochondrial phosphate ion transmembrane transport

Subcellular Location

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Subcellular Location
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR018108 Mitochondrial substrate/solute carrierRepeatRepeat
IPR023395 Mitochondrial carrier domain superfamilyFamilyHomologous superfamily
IPR044677 Mitochondrial phosphate carrier protein Pic2/Mir1-likeFamilyFamily

Diseases

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Disease IDSourceNameDescription
610773 OMIMMitochondrial phosphate carrier deficiency (MPCD)Fatal disorder of oxidative phosphorylation. Patients have lactic acidosis, hypertrophic cardiomyopathy and muscular hypotonia and die within the first year of life. The disease is caused by variants affecting the gene represented in this entry.