Entity Details

Primary name U520_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75643
EntryNameU520_HUMAN
FullNameU5 small nuclear ribonucleoprotein 200 kDa helicase
TaxID9606
Evidenceevidence at protein level
Length2136
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesSNRNP200

GO terms

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GOName
GO:0000354 cis assembly of pre-catalytic spliceosome
GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
GO:0000398 mRNA splicing, via spliceosome
GO:0001649 osteoblast differentiation
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0016020 membrane
GO:0042802 identical protein binding
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071006 U2-type catalytic step 1 spliceosome
GO:0071013 catalytic step 2 spliceosome

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001650 Helicase, C-terminalDomainDomain
IPR004179 Sec63 domainDomainDomain
IPR011545 DEAD/DEAH box helicase domainDomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR041094 Brr2, N-terminal helicase PWI domainDomainDomain

Diseases

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Interactions

72 interactions

InteractorPartnerSourcesPublicationsLink
U520_HUMANMEG10_HUMANBioGRID, HPRD, IntAct12421765 details
U520_HUMANSNR40_HUMANBioGRID, IntAct, UniProt16723661 17353931 22939629 26186194 26344197 28514442 9774689 details
U520_HUMANPRP8_HUMANBioGRID, DIP, IntAct, UniProt16723661 17317632 22939629 23704370 26344197 27173435 28515276 31914407 34079125 9774689 unassigned1312 details
U520_HUMANGRB2_HUMANBioGRID, IntAct18624398 details
U520_HUMANSNW1_HUMANBioGRID, MINT, UniProt12840015 20467437 25849387 26344197 details
U520_HUMANU520_HUMANBioGRID, MINT16723661 22365833 25849387 details
U520_HUMANR113A_HUMANBioGRID, MINT22365833 details
U520_HUMANSF3B2_HUMANBioGRID, MINT22365833 25849387 details
U520_HUMANLSM8_HUMANBioGRID, MINT22365833 details
U520_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
U520_HUMANCHM1B_HUMANBioGRID, HPRD, IntAct16730941 details
U520_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
U520_HUMANPRP6_HUMANBioGRID, IntAct, UniProt16723661 22939629 26344197 27173435 unassigned1312 details
U520_HUMANGNMT_HUMANBioGRID, IntAct32296183 details
U520_HUMANU5S1_HUMANBioGRID, IntAct, UniProt16723661 22939629 25263594 25849387 26344197 27173435 28515276 unassigned1312 details
U520_HUMANPRPF3_HUMANBioGRID, IntAct25849387 28514442 details
U520_HUMANWBP4_HUMANBioGRID, IntAct28838205 details
U520_HUMANSNUT1_HUMANBioGRID, UniProt16723661 26344197 details
U520_HUMANAPC_HUMANBioGRID20936779 details
U520_HUMANROA1_HUMANBioGRID22446626 25849387 details
U520_HUMANSF3B3_HUMANBioGRID22939629 25849387 details
U520_HUMANSPF27_HUMANBioGRID22939629 25849387 details
U520_HUMANBARD1_HUMANBioGRID22990118 details
U520_HUMANBRCA1_HUMANBioGRID22990118 26831064 details
U520_HUMANECT2_HUMANBioGRID22990118 31586073 details
U520_HUMANUBP19_HUMANBioGRID23500468 details
U520_HUMANPIN1_HUMANBioGRID16055720 details
U520_HUMANERG_HUMANBioGRID24591637 details
U520_HUMANUBC9_HUMANBioGRID19596686 details
U520_HUMANPRP31_HUMANBioGRID25849387 26344197 details
U520_HUMANMATR3_HUMANBioGRID25849387 29511296 29884807 details
U520_HUMANPRP16_HUMANBioGRID25849387 details
U520_HUMANPTEN_HUMANBioGRID31685992 details
U520_HUMANSUMO2_HUMANBioGRID32786267 details
U520_HUMANCBP_HUMANBioGRID32238831 details
U520_HUMAN1433B_HUMANHPRD, IntAct, MINT15324660 17353931 details
U520_HUMAN1433G_HUMANBioGRID, HPRD, IntAct, MINT15324660 17353931 details
U520_HUMANCD2B2_HUMANBioGRID, IntAct17353931 22939629 26344197 27173435 28514442 28561026 unassigned1312 details
U520_HUMANCASP4_HUMANIntAct17353931 details
U520_HUMANVHL_HUMANIntAct17353931 details
U520_HUMANCIAO1_HUMANIntAct17353931 details
U520_HUMANIKKE_HUMANIntAct17353931 details
U520_HUMANEPB41_HUMANIntAct17353931 details
U520_HUMANSF3A2_HUMANBioGRID, MINT17332742 26344197 details
U520_HUMANSMAD2_HUMANIntAct20195357 details
U520_HUMANCDC5L_HUMANBioGRID, MINT17332742 20467437 22939629 29395067 details
U520_HUMANRIOK1_HUMANBioGRID, IntAct21081503 27173435 unassigned1312 details
U520_HUMANSMU1_HUMANBioGRID, IntAct27173435 unassigned1312 details
U520_HUMANDISC1_HUMANIntAct31413325 details
U520_HUMANSPF30_HUMANBioGRID, HPRD11331595 details
U520_HUMANSRRM1_HUMANBioGRID16159877 details
U520_HUMANHDAC5_HUMANBioGRID21081666 details
U520_HUMANRBM39_HUMANBioGRID16051665 28302793 details
U520_HUMANISG15_HUMANBioGRID16009940 33024031 details
U520_HUMANU2AF2_HUMANBioGRID22939629 26641092 details
U520_HUMANRBM5_HUMANBioGRID22569250 details
U520_HUMANITA4_HUMANBioGRID22623428 details
U520_HUMANPHF6_HUMANBioGRID22720776 details
U520_HUMANSIR6_HUMANBioGRID24169447 details
U520_HUMANTTC27_HUMANBioGRID26472760 details
U520_HUMANCA131_HUMANBioGRID26472760 details
U520_HUMANTLS1_HUMANBioGRID26472760 details
U520_HUMANDPF3_HUMANBioGRID26582913 details
U520_HUMANZNHI2_HUMANBioGRID28561026 details
U520_HUMANFGF11_HUMANBioGRID28027390 details
U520_HUMANSMC1A_HUMANBioGRID31010829 details
U520_HUMANSMC3_HUMANBioGRID31010829 details
U520_HUMANSTAG2_HUMANBioGRID31010829 details
U520_HUMANPDS5A_HUMANBioGRID31010829 details
U520_HUMANNIPBL_HUMANBioGRID31010829 details
U520_HUMANSTAG1_HUMANBioGRID31010829 details
U520_HUMANWAPL_HUMANBioGRID31010829 details