Entity Details

Primary name MMP9_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14780
EntryNameMMP9_HUMAN
FullNameMatrix metalloproteinase-9
TaxID9606
Evidenceevidence at protein level
Length707
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesMMP9

GO terms

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GOName
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001934 positive regulation of protein phosphorylation
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006508 proteolysis
GO:0007566 embryo implantation
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0019221 cytokine-mediated signaling pathway
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030225 macrophage differentiation
GO:0030335 positive regulation of cell migration
GO:0030574 collagen catabolic process
GO:0034614 cellular response to reactive oxygen species
GO:0035987 endodermal cell differentiation
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0043388 positive regulation of DNA binding
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051549 positive regulation of keratinocyte migration
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0071276 cellular response to cadmium ion
GO:0071492 cellular response to UV-A
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0150077 regulation of neuroinflammatory response
GO:1900122 positive regulation of receptor binding
GO:1904645 response to amyloid-beta
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904724 tertiary granule lumen
GO:1904813 ficolin-1-rich granule lumen
GO:2000697 negative regulation of epithelial cell differentiation involved in kidney development
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
GO:2001258 negative regulation of cation channel activity
GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000562 Fibronectin type II domainDomainDomain
IPR000585 Hemopexin-like domainDomainDomain
IPR001818 Peptidase M10, metallopeptidaseDomainDomain
IPR002477 Peptidoglycan binding-likeDomainDomain
IPR006026 Peptidase, metallopeptidaseDomainDomain
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR018486 Hemopexin, conserved siteSiteConserved site
IPR018487 Hemopexin-like repeatsRepeatRepeat
IPR021158 Peptidase M10A, cysteine switch, zinc binding siteSiteBinding site
IPR021190 Peptidase M10AFamilyFamily
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR028688 Matrix metalloproteinase-9FamilyFamily
IPR033739 Peptidase M10A, catalytic domainDomainDomain
IPR036365 PGBD-like superfamilyFamilyHomologous superfamily
IPR036366 PGBD superfamilyFamilyHomologous superfamily
IPR036375 Hemopexin-like domain superfamilyFamilyHomologous superfamily
IPR036943 Fibronectin type II domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613073 OMIMMetaphyseal anadysplasia 2 (MANDP2)A bone development disorder characterized by skeletal anomalies that resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia. The disease is caused by variants affecting the gene represented in this entry.
603932 OMIMIntervertebral disc disease (IDD)A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00143 GlutathioneDrugbanksmall molecule
DB00786 MarimastatDrugbanksmall molecule
DB01017 MinocyclineDrugbanksmall molecule
DB01197 CaptoprilDrugbanksmall molecule
DB01296 GlucosamineDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB01949 2-Amino-N,3,3-TrimethylbutanamideDrugbanksmall molecule
DB03683 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic AcidDrugbanksmall molecule
DB05387 AE-941Drugbanksmall molecule
DB05495 PG-530742Drugbanksmall molecule
DB06423 EndostatinDrugbankbiotech
DB07117 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONEDrugbanksmall molecule
DB07246 (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDEDrugbanksmall molecule
DB07285 (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACIDDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
MMP9_HUMANELN_HUMANMINT20345904 details
MMP9_HUMANSCUB3_HUMANI2D21441952 details
MMP9_HUMANMEP1A_HUMANMINT23123160 details
MMP9_HUMANMEP1B_HUMANMINT23123160 details
MMP9_HUMANTGFB1_HUMANBioGRID, IntAct10652271 25241761 details
MMP9_HUMANMMP9_HUMANDIP, HPRD, MINT12051944 17937912 18077379 23601700 details
MMP9_HUMANCSPG2_HUMANMINT23601700 details
MMP9_HUMANSRGN_HUMANMINT23601700 details
MMP9_HUMANTIMP1_HUMANBioGRID, IntAct24330623 28514442 details
MMP9_HUMANCXCL5_HUMANBioGRID, HPRD10095777 12950257 details
MMP9_HUMANCXCL6_HUMANBioGRID12950257 details
MMP9_HUMANTSP1_HUMANBioGRID, HPRD10900205 11606713 details
MMP9_HUMANTSP2_HUMANBioGRID, HPRD10900205 details
MMP9_HUMANBGH3_HUMANBioGRID23019342 details
MMP9_HUMANFINC_HUMANBioGRID, HPRD, IntAct11134254 28514442 details
MMP9_HUMANCO4A2_HUMANBioGRID, HPRD, IntAct28514442 9878537 details
MMP9_HUMANCO4A1_HUMANBioGRID, HPRD, IntAct28514442 9878537 details
MMP9_HUMANNGAL_HUMANDIP, HPRD10339412 1281792 18077379 details
MMP9_HUMANCLUS_HUMANBioGRID26716898 details
MMP9_HUMANCATB_HUMANBioGRID26208400 details
MMP9_HUMANHPLN1_HUMANHPRD7694569 details
MMP9_HUMANCO4A3_HUMANHPRD9878537 details
MMP9_HUMANCO4A4_HUMANHPRD9878537 details
MMP9_HUMANCO1A1_HUMANHPRD9878537 details
MMP9_HUMANCO1A2_HUMANHPRD9878537 details
MMP9_HUMANIL8_HUMANHPRD11023497 details
MMP9_HUMANGROA_HUMANHPRD11023497 details
MMP9_HUMANPLMN_HUMANHPRD9360944 details
MMP9_HUMANMMP7_HUMANHPRD7896811 details
MMP9_HUMANTIMP3_HUMANHPRD11827795 details
MMP9_HUMANCO4A5_HUMANHPRD9878537 details
MMP9_HUMANCO4A6_HUMANHPRD9878537 details
MMP9_HUMANBTC_HUMANHPRD10706134 details
MMP9_HUMANKISS1_HUMANHPRD12879005 details
MMP9_HUMANRECK_HUMANHPRD9789069 details
MMP9_HUMANMMP26_HUMANHPRD12586837 details
MMP9_HUMANTFPI1_HUMANHPRD10859319 details
MMP9_HUMANTRY2_HUMANHPRD9261109 9578462 details
MMP9_HUMANMMP10_HUMANHPRD9578462 details
MMP9_HUMANEPHB2_HUMANHPRD18713744 details
MMP9_HUMANAREG_HUMANHPRD10389762 details
MMP9_HUMANCD44_HUMANHPRD10652271 17912438 details