Entity Details

Primary name BMR1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP36894
EntryNameBMR1A_HUMAN
FullNameBone morphogenetic protein receptor type-1A
TaxID9606
Evidenceevidence at protein level
Length532
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesBMPR1A

GO terms

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GOName
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001707 mesoderm formation
GO:0001756 somitogenesis
GO:0001880 Mullerian duct regression
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002062 chondrocyte differentiation
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003161 cardiac conduction system development
GO:0003171 atrioventricular valve development
GO:0003183 mitral valve morphogenesis
GO:0003186 tricuspid valve morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003223 ventricular compact myocardium morphogenesis
GO:0003272 endocardial cushion formation
GO:0004674 protein serine/threonine kinase activity
GO:0005025 transforming growth factor beta receptor activity, type I
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006955 immune response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007398 ectoderm development
GO:0009897 external side of plasma membrane
GO:0009950 dorsal/ventral axis specification
GO:0009953 dorsal/ventral pattern formation
GO:0010629 negative regulation of gene expression
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014032 neural crest cell development
GO:0014912 negative regulation of smooth muscle cell migration
GO:0016021 integral component of membrane
GO:0019827 stem cell population maintenance
GO:0021983 pituitary gland development
GO:0021998 neural plate mediolateral regionalization
GO:0030324 lung development
GO:0030425 dendrite
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0032915 positive regulation of transforming growth factor beta2 production
GO:0035137 hindlimb morphogenesis
GO:0035912 dorsal aorta morphogenesis
GO:0036122 BMP binding
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0042803 protein homodimerization activity
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0045669 positive regulation of osteoblast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0046872 metal ion binding
GO:0048352 paraxial mesoderm structural organization
GO:0048368 lateral mesoderm development
GO:0048378 regulation of lateral mesodermal cell fate specification
GO:0048382 mesendoderm development
GO:0048568 embryonic organ development
GO:0048589 developmental growth
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050768 negative regulation of neurogenesis
GO:0051148 negative regulation of muscle cell differentiation
GO:0060021 roof of mouth development
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060412 ventricular septum morphogenesis
GO:0060914 heart formation
GO:0060928 atrioventricular node cell development
GO:0061312 BMP signaling pathway involved in heart development
GO:0061626 pharyngeal arch artery morphogenesis
GO:0071363 cellular response to growth factor stimulus
GO:0071773 cellular response to BMP stimulus
GO:0098821 BMP receptor activity
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1904414 positive regulation of cardiac ventricle development
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1905285 fibrous ring of heart morphogenesis
GO:1990712 HFE-transferrin receptor complex
GO:2000772 regulation of cellular senescence

Subcellular Location

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Subcellular Location
Cell membrane
Cell surface

Domains

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DomainNameCategoryType
IPR000333 Ser/Thr protein kinase, TGFB receptorFamilyFamily
IPR000472 Activin types I and II receptor domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003605 GS domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Disease IDSourceNameDescription
610069 OMIMPolyposis syndrome, mixed hereditary 2 (HMPS2)A disease is characterized by atypical juvenile polyps, colonic adenomas, and colorectal carcinomas. The disease is caused by variants affecting the gene represented in this entry.
174900 OMIMJuvenile polyposis syndrome (JPS)Autosomal dominant gastrointestinal hamartomatous polyposis syndrome in which patients are at risk for developing gastrointestinal cancers. The lesions are typified by a smooth histological appearance, predominant stroma, cystic spaces and lack of a smooth muscle core. Multiple juvenile polyps usually occur in a number of Mendelian disorders. Sometimes, these polyps occur without associated features as in JPS; here, polyps tend to occur in the large bowel and are associated with an increased risk of colon and other gastrointestinal cancers. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB11639 Dibotermin alfaDrugbankbiotech

Interactions

61 interactions

InteractorPartnerSourcesPublicationsLink
BMR1A_HUMANBMP2_HUMANBioGRID, DIP, HPRD, IntAct, MINT10692589 10712517 10880444 10881198 11263668 15064755 16672363 18070108 19804412 20860622 21054789 25938661 details
BMR1A_HUMANGDF5_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11282024 16127465 19229295 21543859 9525338 details
BMR1A_HUMANFSTL1_HUMANMINT20860622 details
BMR1A_HUMANBMP4_HUMANBioGRID, HPRD, MINT11241215 20860622 21054789 27684187 28126904 7644468 8006002 8702914 details
BMR1A_HUMANTRMO_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANALDOB_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANAMPO_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANMSD3_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANCDK8_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANCATL2_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANF16P2_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANFANCC_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANF16P1_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANGLT12_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANRASH_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANIBP3_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANSC61B_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANMP2K1_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANRASA1_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANSFRP2_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANSFRP4_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANSMAD1_HUMANBioGRID, HPRD, MINT11438941 24412244 9136927 details
BMR1A_HUMANTGFB1_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANXPA_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANZN189_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANACVR1_HUMANBioGRID, IntAct18436533 26186194 28514442 details
BMR1A_HUMANSF3B4_HUMANBioGRID, HPRD15351706 details
BMR1A_HUMANFKB1B_HUMANBioGRID15351706 details
BMR1A_HUMANGDF6_HUMANBioGRID, HPRD9525338 details
BMR1A_HUMANBMP7_HUMANBioGRID, HPRD18070108 7791754 8006002 8605097 details
BMR1A_HUMANBMP6_HUMANBioGRID, HPRD10504300 11401330 18070108 details
BMR1A_HUMANFKB1A_HUMANBioGRID9663660 details
BMR1A_HUMANZMY11_HUMANBioGRID, HPRD9663660 details
BMR1A_HUMANBMR1A_HUMANBioGRID, HPRD10712517 18436533 details
BMR1A_HUMANNED4L_HUMANBioGRID19953087 details
BMR1A_HUMANNEDD4_HUMANBioGRID19953087 details
BMR1A_HUMANBAMBI_HUMANBioGRID19758997 details
BMR1A_HUMANUBP15_HUMANBioGRID24850914 details
BMR1A_HUMANOTUB1_HUMANBioGRID25872870 details
BMR1A_HUMANTDGF1_HUMANBioGRID28126904 details
BMR1A_HUMANTAB1_HUMANHPRD9663660 details
BMR1A_HUMANHS90B_HUMANBioGRID, IntAct22939624 27684187 details
BMR1A_HUMANSMAD7_HUMANBioGRID15148321 20663871 details
BMR1A_HUMANBMPR2_HUMANBioGRID, HPRD10712517 7791754 details
BMR1A_HUMANBMR1B_HUMANBioGRID, HPRD10712517 details
BMR1A_HUMANRUNX2_HUMANBioGRID16613856 details
BMR1A_HUMANT22D1_HUMANBioGRID21791611 details
BMR1A_HUMANIGSF1_HUMANBioGRID11266516 details
BMR1A_HUMANFST_HUMANBioGRID16198295 details
BMR1A_HUMANSMUF1_HUMANBioGRID12857866 details
BMR1A_HUMANSMAD6_HUMANBioGRID20663871 details
BMR1A_HUMANHS90A_HUMANBioGRID22939624 27684187 details
BMR1A_HUMANPEG10_HUMANBioGRID15611116 details
BMR1A_HUMANCAV1_HUMANBioGRID15657086 details
BMR1A_HUMANRGMB_HUMANBioGRID15671031 details
BMR1A_HUMANAVR2A_HUMANBioGRID15940369 details
BMR1A_HUMANPSDE_HUMANBioGRID31685442 details
BMR1A_HUMANBMP5_HUMANHPRD11580864 details
BMR1A_HUMANGDF9_HUMANHPRD10712517 12135884 details
BMR1A_HUMANTGFA1_HUMANHPRD11278302 details
BMR1A_HUMANHXC8_HUMANHPRD11139569 details