Entity Details

Primary name STXB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP61764
EntryNameSTXB1_HUMAN
FullNameSyntaxin-binding protein 1
TaxID9606
Evidenceevidence at protein level
Length594
SequenceStatuscomplete
DateCreated2004-06-07
DateModified2021-06-02

Ontological Relatives

GenesSTXBP1

GO terms

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GOName
GO:0000149 SNARE binding
GO:0002576 platelet degranulation
GO:0003006 developmental process involved in reproduction
GO:0003723 RNA binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006836 neurotransmitter transport
GO:0006886 intracellular protein transport
GO:0006904 vesicle docking involved in exocytosis
GO:0007269 neurotransmitter secretion
GO:0007274 neuromuscular synaptic transmission
GO:0007412 axon target recognition
GO:0010807 regulation of synaptic vesicle priming
GO:0016082 synaptic vesicle priming
GO:0016188 synaptic vesicle maturation
GO:0016192 vesicle-mediated transport
GO:0017075 syntaxin-1 binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0019905 syntaxin binding
GO:0030141 secretory granule
GO:0030424 axon
GO:0031091 platelet alpha granule
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane
GO:0032229 negative regulation of synaptic transmission, GABAergic
GO:0032355 response to estradiol
GO:0032991 protein-containing complex
GO:0035493 SNARE complex assembly
GO:0035542 regulation of SNARE complex assembly
GO:0042802 identical protein binding
GO:0043274 phospholipase binding
GO:0043306 positive regulation of mast cell degranulation
GO:0043524 negative regulation of neuron apoptotic process
GO:0045335 phagocytic vesicle
GO:0045956 positive regulation of calcium ion-dependent exocytosis
GO:0047485 protein N-terminus binding
GO:0048471 perinuclear region of cytoplasm
GO:0048787 presynaptic active zone membrane
GO:0050821 protein stabilization
GO:0060292 long-term synaptic depression
GO:0070062 extracellular exosome
GO:0070527 platelet aggregation
GO:0071346 cellular response to interferon-gamma
GO:0072659 protein localization to plasma membrane
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0099525 presynaptic dense core vesicle exocytosis
GO:0106022 positive regulation of vesicle docking
GO:1903296 positive regulation of glutamate secretion, neurotransmission
GO:2000367 regulation of acrosomal vesicle exocytosis

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR001619 Sec1-like proteinFamilyFamily
IPR027482 Sec1-like, domain 2FamilyHomologous superfamily
IPR036045 Sec1-like superfamilyFamilyHomologous superfamily
IPR043127 Sec1-like, domain 3aFamilyHomologous superfamily
IPR043154 Sec1-like, domain 1FamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
612164 OMIMDevelopmental and epileptic encephalopathy 4 (DEE4)A severe form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Affected individuals have neonatal or infantile onset of seizures, profound mental retardation, and MRI evidence of brain hypomyelination. The disease is caused by variants affecting the gene represented in this entry.

Interactions

73 interactions

InteractorPartnerSourcesPublicationsLink
STXB1_HUMANA4_HUMANBioGRID, IntAct16049941 21832049 32814053 details
STXB1_HUMANPLD1_HUMANHPRD, MINT14744865 19323535 details
STXB1_HUMANHD_HUMANIntAct17500595 32814053 details
STXB1_HUMANTRI38_HUMANBioGRID, IntAct25416956 25910212 32296183 details
STXB1_HUMANSTX11_HUMANBioGRID, IntAct25416956 25910212 28514442 details
STXB1_HUMANSTX19_HUMANBioGRID, IntAct25416956 25910212 26186194 28514442 32296183 details
STXB1_HUMANMTR1A_HUMANBioGRID, IntAct26514267 details
STXB1_HUMANCENPP_HUMANBioGRID, IntAct32296183 details
STXB1_HUMANSTX5_HUMANBioGRID, IntAct25910212 32296183 details
STXB1_HUMANSPICE_HUMANBioGRID, IntAct32296183 details
STXB1_HUMANMK01_HUMANBioGRID, IntAct32296183 details
STXB1_HUMANSYTL4_HUMANBioGRID, HPRD, IntAct12590134 15563604 24700782 32296183 details
STXB1_HUMANBRME1_HUMANBioGRID, IntAct25910212 details
STXB1_HUMANMEOX2_HUMANBioGRID, IntAct25910212 details
STXB1_HUMANSTX1B_HUMANBioGRID, HPRD, IntAct12093152 31413325 details
STXB1_HUMANSTX1A_HUMANBioGRID, HPRD, IntAct10194441 10449403 10746715 12093152 12519779 12963086 15563604 17363971 31413325 7553862 8108429 9045631 details
STXB1_HUMANDRD4_HUMANIntAct32814053 details
STXB1_HUMANKLF11_HUMANIntAct32814053 details
STXB1_HUMANNCOR1_HUMANIntAct32814053 details
STXB1_HUMANHGS_HUMANBioGRID19019082 details
STXB1_HUMANSQSTM_HUMANBioGRID14702098 details
STXB1_HUMANAPBA1_HUMANBioGRID, HPRD15563604 9395480 details
STXB1_HUMANAPBA2_HUMANBioGRID, HPRD15563604 9395480 details
STXB1_HUMANKPCA_HUMANBioGRID, HPRD12519779 12950453 8631738 details
STXB1_HUMANSPTB2_HUMANBioGRID21866423 details
STXB1_HUMANDOC2A_HUMANHPRD9115738 details
STXB1_HUMANDOC2B_HUMANHPRD9115738 details
STXB1_HUMANKAP0_HUMANIntAct20195357 details
STXB1_HUMANHSP7C_HUMANIntAct25910212 details
STXB1_HUMANSTX3_HUMANBioGRID, HPRD, IntAct17363971 24700782 26186194 28514442 9045631 details
STXB1_HUMANPSN1_HUMANUniProt25893612 details
STXB1_HUMANPARP2_HUMANIntAct31413325 details
STXB1_HUMANCC148_HUMANIntAct31413325 details
STXB1_HUMANABCA3_HUMANIntAct31413325 details
STXB1_HUMANARHGC_HUMANIntAct31413325 details
STXB1_HUMANTCPR1_HUMANIntAct31413325 details
STXB1_HUMANBIN1_HUMANIntAct31413325 details
STXB1_HUMANKCMB4_HUMANIntAct31413325 details
STXB1_HUMANPARVB_HUMANIntAct31413325 details
STXB1_HUMANMY18A_HUMANIntAct31413325 details
STXB1_HUMANNP1L2_HUMANIntAct31413325 details
STXB1_HUMANNASP_HUMANIntAct31413325 details
STXB1_HUMANOPA1_HUMANIntAct31413325 details
STXB1_HUMANTE2IP_HUMANIntAct31413325 details
STXB1_HUMANIMP3_HUMANIntAct31413325 details
STXB1_HUMANCAND1_HUMANIntAct31413325 details
STXB1_HUMANAN36B_HUMANIntAct31413325 details
STXB1_HUMANGDS1_HUMANIntAct31413325 details
STXB1_HUMANRS13_HUMANIntAct31413325 details
STXB1_HUMANSH3G1_HUMANIntAct31413325 details
STXB1_HUMANDYST_HUMANIntAct31413325 details
STXB1_HUMANSPTN2_HUMANIntAct31413325 details
STXB1_HUMANDISC1_HUMANIntAct31413325 details
STXB1_HUMANOBI1_HUMANIntAct31413325 details
STXB1_HUMANCEP70_HUMANIntAct31413325 details
STXB1_HUMANACTN1_HUMANIntAct31413325 details
STXB1_HUMANKALRN_HUMANIntAct31413325 details
STXB1_HUMANSESD1_HUMANIntAct31413325 details
STXB1_HUMANIF2P_HUMANIntAct31413325 details
STXB1_HUMANCDK5_HUMANBioGRID, HPRD12963086 details
STXB1_HUMANTAU_HUMANBioGRID, HPRD12963086 details
STXB1_HUMANTBB2A_HUMANBioGRID12963086 details
STXB1_HUMANTBA4A_HUMANBioGRID12963086 details
STXB1_HUMANSTX2_HUMANBioGRID, HPRD12773094 24700782 9045631 details
STXB1_HUMANSTX4_HUMANBioGRID12773094 details
STXB1_HUMANPREX1_HUMANBioGRID26792863 details
STXB1_HUMANKPCB_HUMANHPRD12519779 12950453 8631738 details
STXB1_HUMANKPCG_HUMANHPRD12519779 12950453 8631738 details
STXB1_HUMANUSO1_HUMANHPRD10903204 11927603 details
STXB1_HUMANCD5R1_HUMANHPRD9933594 details
STXB1_HUMANPLD2_HUMANHPRD14744865 details
STXB1_HUMANNFH_HUMANHPRD12963086 details
STXB1_HUMANNFM_HUMANHPRD12963086 details