Entity Details

Primary name RUNX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ01196
EntryNameRUNX1_HUMAN
FullNameRunt-related transcription factor 1
TaxID9606
Evidenceevidence at protein level
Length453
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesRUNX1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001503 ossification
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0002062 chondrocyte differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0008134 transcription factor binding
GO:0010629 negative regulation of gene expression
GO:0010755 regulation of plasminogen activation
GO:0016513 core-binding factor complex
GO:0030097 hemopoiesis
GO:0030099 myeloid cell differentiation
GO:0030111 regulation of Wnt signaling pathway
GO:0030182 neuron differentiation
GO:0030853 negative regulation of granulocyte differentiation
GO:0030854 positive regulation of granulocyte differentiation
GO:0032743 positive regulation of interleukin-2 production
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0042803 protein homodimerization activity
GO:0043231 intracellular membrane-bounded organelle
GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043378 positive regulation of CD8-positive, alpha-beta T cell differentiation
GO:0045589 regulation of regulatory T cell differentiation
GO:0045595 regulation of cell differentiation
GO:0045616 regulation of keratinocyte differentiation
GO:0045637 regulation of myeloid cell differentiation
GO:0045652 regulation of megakaryocyte differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0048935 peripheral nervous system neuron development
GO:0050855 regulation of B cell receptor signaling pathway
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0061026 cardiac muscle tissue regeneration
GO:0071425 hematopoietic stem cell proliferation
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1903055 positive regulation of extracellular matrix organization
GO:1905203 regulation of connective tissue replacement
GO:2000810 regulation of bicellular tight junction assembly

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000040 Acute myeloid leukemia 1 protein (AML1)/RuntFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR013524 Runt domainDomainDomain
IPR013711 Runx, C-terminal domainDomainDomain
IPR016554 Runt-related transcription factor RUNXFamilyFamily
IPR027384 Runx, central domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
601399 OMIMFamilial platelet disorder with associated myeloid malignancy (FPDMM)Autosomal dominant disease characterized by qualitative and quantitative platelet defects, and propensity to develop acute myelogenous leukemia. The disease is caused by variants affecting the gene represented in this entry.

Interactions

104 interactions

InteractorPartnerSourcesPublicationsLink
RUNX1_HUMANWWTR1_HUMANHPRD, MINT11118213 details
RUNX1_HUMANTLE1_HUMANBioGRID, HPRD, IntAct9751710 details
RUNX1_HUMANELF2_HUMANBioGRID, HPRD, IntAct10207087 14970218 details
RUNX1_HUMANELF4_HUMANBioGRID, HPRD, IntAct10207087 14970218 details
RUNX1_HUMANHIPK2_HUMANBioGRID, HPRD, MINT16917507 details
RUNX1_HUMANEP300_HUMANBioGRID, HPRD, MINT14752096 16917507 details
RUNX1_HUMANPEBB_HUMANBioGRID, DIP, HPRD, IntAct, MINT10856244 11276260 11742995 14729951 14752096 15331439 17431401 20195544 22498736 23333304 25678665 26598521 2845103 28536267 31048839 31253590 32296183 details
RUNX1_HUMANYAP1_HUMANBioGRID, HPRD, MINT10228168 18280240 18701449 25283809 details
RUNX1_HUMANFOXP3_HUMANBioGRID, DIP, HPRD17377532 details
RUNX1_HUMANBAG3_HUMANBioGRID, IntAct32296183 details
RUNX1_HUMANFBX17_HUMANBioGRID, IntAct32296183 details
RUNX1_HUMANRU1C_HUMANBioGRID, IntAct32296183 details
RUNX1_HUMANBAG4_HUMANBioGRID, IntAct32296183 details
RUNX1_HUMANHGS_HUMANBioGRID, IntAct32296183 details
RUNX1_HUMANGCC1_HUMANBioGRID, IntAct32296183 details
RUNX1_HUMANVP37C_HUMANBioGRID, IntAct32296183 details
RUNX1_HUMANOLIG3_HUMANBioGRID, IntAct32296183 details
RUNX1_HUMANTEKT5_HUMANBioGRID, IntAct32296183 details
RUNX1_HUMANF222B_HUMANBioGRID, IntAct32296183 details
RUNX1_HUMANCCNK_HUMANBioGRID, IntAct28533407 32296183 details
RUNX1_HUMANIKBD_HUMANBioGRID, IntAct32296183 details
RUNX1_HUMANTEAD4_HUMANBioGRID, IntAct32296183 details
RUNX1_HUMANTEAD2_HUMANBioGRID, IntAct32296183 details
RUNX1_HUMANGSK3A_HUMANBioGRID, UniProt30824926 details
RUNX1_HUMANSUV91_HUMANBioGRID, HPRD12917624 16652147 details
RUNX1_HUMANTLE5_HUMANBioGRID10825294 details
RUNX1_HUMANPAX5_HUMANBioGRID, HPRD10455134 details
RUNX1_HUMANJUN_HUMANBioGRID, HPRD11274169 11641401 details
RUNX1_HUMANFOS_HUMANBioGRID, HPRD11274169 11641401 details
RUNX1_HUMANVDR_HUMANBioGRID12460926 details
RUNX1_HUMANCEBPB_HUMANBioGRID, HPRD8622667 details
RUNX1_HUMANMYOD1_HUMANBioGRID20195544 details
RUNX1_HUMANHDAC1_HUMANBioGRID16652147 21059642 22498736 26598521 details
RUNX1_HUMANHDAC3_HUMANBioGRID16652147 21059642 26598521 details
RUNX1_HUMANKAT6A_HUMANBioGRID, HPRD11742995 15331439 16702405 details
RUNX1_HUMANNCOR1_HUMANBioGRID10882117 details
RUNX1_HUMANUB2L6_HUMANBioGRID18073335 details
RUNX1_HUMANCHIP_HUMANBioGRID19524548 28536267 details
RUNX1_HUMANCDK1_HUMANBioGRID21059642 details
RUNX1_HUMANCOPRS_HUMANBioGRID22193545 details
RUNX1_HUMANRBM14_HUMANBioGRID19585539 28533407 details
RUNX1_HUMANMINT_HUMANBioGRID18332109 details
RUNX1_HUMANDNMT1_HUMANBioGRID15735013 28533407 details
RUNX1_HUMANANM1_HUMANBioGRID22498736 details
RUNX1_HUMANUXT_HUMANBioGRID17635584 details
RUNX1_HUMANCTBP2_HUMANBioGRID17635584 30585266 details
RUNX1_HUMANNCOR2_HUMANBioGRID, HPRD16042694 17560331 details
RUNX1_HUMANSPI1_HUMANBioGRID10207087 details
RUNX1_HUMANELF1_HUMANBioGRID10207087 details
RUNX1_HUMANWWP1_HUMANBioGRID28536267 details
RUNX1_HUMANRNF38_HUMANBioGRID28536267 details
RUNX1_HUMANRNF44_HUMANBioGRID28536267 details
RUNX1_HUMANDTX2_HUMANBioGRID28536267 details
RUNX1_HUMANTRIM5_HUMANBioGRID28536267 details
RUNX1_HUMANUHRF2_HUMANBioGRID28536267 details
RUNX1_HUMANDZIP3_HUMANBioGRID28536267 details
RUNX1_HUMANNEDD4_HUMANBioGRID28536267 details
RUNX1_HUMANHIF1A_HUMANBioGRID17684492 details
RUNX1_HUMANIKZF3_HUMANBioGRID30760870 details
RUNX1_HUMANIKZF1_HUMANBioGRID30760870 details
RUNX1_HUMANMK01_HUMANBioGRID22253733 details
RUNX1_HUMANCCND3_HUMANHPRD16287839 details
RUNX1_HUMANCBP_HUMANBioGRID, MINT15331439 16917507 details
RUNX1_HUMANCDK6_HUMANBioGRID, HPRD, IntAct, MINT17431401 25241761 details
RUNX1_HUMANCEBPA_HUMANHPRD, MINT17431401 details
RUNX1_HUMANSP1_HUMANMINT18519037 details
RUNX1_HUMANTAL1_HUMANBioGRID, DIP, MINT19497860 21179004 details
RUNX1_HUMANHMGA2_HUMANIntAct29391048 details
RUNX1_HUMANKAT6B_HUMANBioGRID, HPRD11965546 details
RUNX1_HUMANSMAD3_HUMANBioGRID10531362 15897867 details
RUNX1_HUMANSMAD1_HUMANBioGRID10531362 details
RUNX1_HUMANSMAD2_HUMANBioGRID10531362 details
RUNX1_HUMANSMAD5_HUMANBioGRID10531362 details
RUNX1_HUMANMTG8R_HUMANBioGRID, HPRD10675041 22498736 9447981 details
RUNX1_HUMANTRAF6_HUMANBioGRID18768464 details
RUNX1_HUMANFHL2_HUMANBioGRID18768464 details
RUNX1_HUMANHTF4_HUMANBioGRID15333839 details
RUNX1_HUMANTFE2_HUMANBioGRID15333839 28533407 details
RUNX1_HUMANMTG8_HUMANBioGRID10882117 22498736 details
RUNX1_HUMANSIAH1_HUMANBioGRID18073335 details
RUNX1_HUMANRUNX1_HUMANBioGRID15897867 18073335 details
RUNX1_HUMANPML_HUMANBioGRID15331439 18073335 details
RUNX1_HUMANRARA_HUMANBioGRID18073335 details
RUNX1_HUMANHDAC2_HUMANBioGRID18073335 22498736 details
RUNX1_HUMANSIN3A_HUMANBioGRID14729951 details
RUNX1_HUMANNR4A2_HUMANBioGRID21468021 details
RUNX1_HUMANSMCA4_HUMANBioGRID20506188 28533407 details
RUNX1_HUMANSNF5_HUMANBioGRID20506188 details
RUNX1_HUMANSMRC1_HUMANBioGRID20506188 28533407 details
RUNX1_HUMANKMT2A_HUMANBioGRID22012064 details
RUNX1_HUMANMTG16_HUMANBioGRID, HPRD14703694 22498736 26593974 28533407 details
RUNX1_HUMANCTBP1_HUMANBioGRID15897867 details
RUNX1_HUMANRAG1_HUMANBioGRID25135298 details
RUNX1_HUMANKLF6_HUMANBioGRID24130502 details
RUNX1_HUMANNFAC1_HUMANBioGRID27637333 details
RUNX1_HUMANNFAC2_HUMANBioGRID27637333 details
RUNX1_HUMANFACD2_HUMANBioGRID25066130 details
RUNX1_HUMANREQU_HUMANBioGRID28533407 details
RUNX1_HUMANANDR_HUMANHPRD10521447 details
RUNX1_HUMANCCND2_HUMANHPRD16287839 details
RUNX1_HUMANCCND1_HUMANHPRD16287839 details
RUNX1_HUMANHIPK1_HUMANHPRD16917507 details
RUNX1_HUMANTAZ_HUMANHPRD11118213 details
RUNX1_HUMANTLE2_HUMANHPRD10825294 details