Entity Details

Primary name PO4F3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15319
EntryNamePO4F3_HUMAN
FullNamePOU domain, class 4, transcription factor 3
TaxID9606
Evidenceevidence at protein level
Length338
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesPOU4F3

GO terms

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GOName
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007601 visual perception
GO:0007605 sensory perception of sound
GO:0021562 vestibulocochlear nerve development
GO:0031290 retinal ganglion cell axon guidance
GO:0042472 inner ear morphogenesis
GO:0042491 inner ear auditory receptor cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048675 axon extension
GO:0050885 neuromuscular process controlling balance
GO:0051402 neuron apoptotic process
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000327 POU-specific domainDomainDomain
IPR001356 Homeobox domainDomainDomain
IPR001387 Cro/C1-type helix-turn-helix domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR010982 Lambda repressor-like, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR013847 POU domainDomainDomain
IPR017970 Homeobox, conserved siteSiteConserved site
IPR032961 POU domain, class 4, transcription factor 3FamilyFamily

Diseases

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Disease IDSourceNameDescription
602459 OMIMDeafness, autosomal dominant, 15 (DFNA15)A form of non-syndromic hearing loss with variable phenotype in terms of age at onset, levels of progression, and shape of audiograms. The disease is caused by variants affecting the gene represented in this entry.

Interactions

6 interactions