Entity Details

Primary name CDC73_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6P1J9
EntryNameCDC73_HUMAN
FullNameParafibromin
TaxID9606
Evidenceevidence at protein level
Length531
SequenceStatuscomplete
DateCreated2005-12-20
DateModified2021-06-02

Ontological Relatives

GenesCDC73

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000781 chromosome, telomeric region
GO:0000993 RNA polymerase II complex binding
GO:0001558 regulation of cell growth
GO:0001711 endodermal cell fate commitment
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006366 transcription by RNA polymerase II
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006378 mRNA polyadenylation
GO:0007049 cell cycle
GO:0008285 negative regulation of cell population proliferation
GO:0010390 histone monoubiquitination
GO:0016055 Wnt signaling pathway
GO:0016567 protein ubiquitination
GO:0016593 Cdc73/Paf1 complex
GO:0019827 stem cell population maintenance
GO:0030177 positive regulation of Wnt signaling pathway
GO:0031442 positive regulation of mRNA 3'-end processing
GO:0031648 protein destabilization
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0033523 histone H2B ubiquitination
GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex
GO:0043066 negative regulation of apoptotic process
GO:0045638 negative regulation of myeloid cell differentiation
GO:0048147 negative regulation of fibroblast proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0071222 cellular response to lipopolysaccharide
GO:1902808 positive regulation of cell cycle G1/S phase transition
GO:1904837 beta-catenin-TCF complex assembly
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR007852 Cdc73/ParafibrominFamilyFamily
IPR031336 Cell division control protein 73, C-terminalDomainDomain
IPR032041 Paf1 complex subunit Cdc73, N-terminal domainDomainDomain
IPR038103 Cell division control protein 73, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

65 interactions

InteractorPartnerSourcesPublicationsLink
CDC73_HUMANVTDB_HUMANBioGRID, HPRD, IntAct16169070 details
CDC73_HUMANKIBRA_HUMANBioGRID, HPRD, IntAct16169070 details
CDC73_HUMANANXA6_HUMANBioGRID, HPRD, IntAct16169070 details
CDC73_HUMANHSP74_HUMANBioGRID, HPRD, IntAct16169070 details
CDC73_HUMANPITH1_HUMANBioGRID, HPRD, IntAct16169070 details
CDC73_HUMANKCNH2_HUMANBioGRID, HPRD, IntAct16169070 details
CDC73_HUMANK1549_HUMANHPRD, IntAct16169070 details
CDC73_HUMANKDIS_HUMANHPRD, IntAct16169070 details
CDC73_HUMANTOM20_HUMANHPRD, IntAct16169070 details
CDC73_HUMANCTNB1_HUMANBioGRID, HPRD, IntAct, MINT16630820 21726809 29774127 details
CDC73_HUMANTCEA1_HUMANBioGRID, IntAct20178742 details
CDC73_HUMANCEP70_HUMANBioGRID, IntAct, MINT21900206 25416956 25910212 32296183 details
CDC73_HUMANDDAH2_HUMANBioGRID, MINT21900206 details
CDC73_HUMANFAF1_HUMANBioGRID, MINT21900206 details
CDC73_HUMANHAP1_HUMANBioGRID, MINT21900206 details
CDC73_HUMANHSF2B_HUMANBioGRID, IntAct, MINT21900206 32296183 details
CDC73_HUMANTIP_HUMANBioGRID, MINT21900206 details
CDC73_HUMANGANP_HUMANBioGRID, MINT21900206 details
CDC73_HUMANFSD2_HUMANBioGRID, IntAct25416956 25910212 31515488 details
CDC73_HUMANHEM1_HUMANBioGRID, IntAct25416956 25910212 31515488 details
CDC73_HUMANGOGA2_HUMANBioGRID, IntAct25416956 25910212 31515488 32296183 details
CDC73_HUMANTFCP2_HUMANBioGRID, IntAct25416956 25910212 details
CDC73_HUMANMTUS2_HUMANBioGRID, IntAct25416956 25910212 32296183 details
CDC73_HUMANKASH5_HUMANBioGRID, IntAct25416956 25910212 details
CDC73_HUMANTSG10_HUMANBioGRID, IntAct25416956 25910212 details
CDC73_HUMANVP37B_HUMANBioGRID, IntAct25416956 details
CDC73_HUMANTRI23_HUMANBioGRID, IntAct32296183 details
CDC73_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
CDC73_HUMANBRE1A_HUMANBioGRID, IntAct22021426 27462432 32296183 details
CDC73_HUMANGG6L9_HUMANBioGRID, IntAct32296183 details
CDC73_HUMANRABE1_HUMANBioGRID, IntAct32296183 details
CDC73_HUMANPTN11_HUMANBioGRID, IntAct21726809 26742426 details
CDC73_HUMANBRE1B_HUMANBioGRID22021426 details
CDC73_HUMANH12_HUMANBioGRID24360965 details
CDC73_HUMANMYC_HUMANBioGRID26687678 30415952 details
CDC73_HUMANITF2_HUMANHPRD, IntAct16630820 details
CDC73_HUMANBCL9_HUMANIntAct16630820 17113272 details
CDC73_HUMANPAF1_HUMANBioGRID, DIP, IntAct, MINT, UniProt15632063 15923622 16024656 18469135 19136632 19410543 20178742 20305087 21726809 22863883 22939629 24981860 26186194 26344197 26496610 27462432 28514442 29774127 details
CDC73_HUMANCTR9_HUMANBioGRID, DIP, IntAct, MINT, UniProt15632063 15923622 16024656 18469135 19136632 20178742 20305087 21726809 22532828 22863883 22939629 24981860 26186194 26344197 26496610 28514442 29774127 details
CDC73_HUMANLEO1_HUMANBioGRID, DIP, IntAct, MINT, UniProt15632063 15923622 16024656 18469135 19136632 20178742 20305087 21726809 22939629 24981860 26186194 26344197 26496610 28514442 29774127 details
CDC73_HUMANRTF1_HUMANBioGRID, IntAct, UniProt15923622 16024656 20178742 details
CDC73_HUMANWDR61_HUMANBioGRID, DIP, IntAct, MINT, UniProt16024656 19136632 20178742 20305087 22451921 24981860 26186194 26344197 26496610 29774127 details
CDC73_HUMANKMT2A_HUMANBioGRID, IntAct20541477 details
CDC73_HUMANRPB1_HUMANBioGRID, DIP, UniProt15632063 15923622 16024656 26659056 details
CDC73_HUMANSPT5H_HUMANBioGRID, IntAct26496610 29395067 details
CDC73_HUMANCSTF2_HUMANBioGRID, DIP19136632 details
CDC73_HUMANCPSF4_HUMANBioGRID, DIP19136632 details
CDC73_HUMANSETB1_HUMANMINT29774127 details
CDC73_HUMANEHMT2_HUMANMINT29774127 details
CDC73_HUMANRBP2_HUMANBioGRID15632063 details
CDC73_HUMANRRAGA_HUMANBioGRID19136632 details
CDC73_HUMANHS90A_HUMANBioGRID20305087 27462432 details
CDC73_HUMANH31_HUMANBioGRID22451921 details
CDC73_HUMANSUV91_HUMANBioGRID21726809 details
CDC73_HUMANBCL9L_HUMANBioGRID17113272 details
CDC73_HUMANDNM3A_HUMANBioGRID21406692 details
CDC73_HUMANDNM3B_HUMANBioGRID21406692 details
CDC73_HUMANH11_HUMANBioGRID24360965 details
CDC73_HUMANTF7L2_HUMANBioGRID16630820 details
CDC73_HUMANH2B2E_HUMANBioGRID27462432 details
CDC73_HUMANH31T_HUMANBioGRID27462432 details
CDC73_HUMANNXF1_HUMANBioGRID29395067 details
CDC73_HUMANMCE1_HUMANBioGRID29395067 details
CDC73_HUMANSMG7_HUMANBioGRID29395067 details
CDC73_HUMANBIN1_HUMANBioGRID31815296 details